Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating, multifactorial disorder characterised by profound fatigue, post-exertional malaise, cognitive impairments, and autonomic dysfunction. Despite its significant impact on quality of life, ME/CFS lacks definitive diagnostic biomarkers, complicating diagnosis and management. Recent evidence highlights potential blood tests for ME/CFS biomarkers in immunological, genetic, metabolic, and bioenergetic domains. Chromosome… Continue reading Development and validation of blood-based diagnostic biomarkers for #Myalgic #Encephalomyelitis/#Chronic Fatigue Syndrome (ME/CFS) using EpiSwitch® 3-dimensional genomic regulatory immuno-genetic profiling
Effect of #exercise snacks on fitness and #cardiometabolic health in physically inactive individuals: systematic review and meta-analysis
Objectives To evaluate the effects of brief bouts of exercise spread throughout the day, termed ‘exercise snacks’, on cardiorespiratory and muscular fitness, and cardiometabolic health outcomes in physically inactive adults and older adults (aged ≥65 years).Design Systematic review and meta-analysis.Data sources Seven databases were searched from inception to April 2025.Eligibility criteria Randomised controlled trials (RCTs)… Continue reading Effect of #exercise snacks on fitness and #cardiometabolic health in physically inactive individuals: systematic review and meta-analysis
The Illusion of #Readiness: Stress Testing Large Frontier Models on Multimodal #Medical Benchmarks
Large frontier models like GPT-5 now achieve top scores on medical benchmarks. But our stress tests tell a different story. Leading systems often guess correctly even when key inputs like images are removed, flip answers under trivial prompt changes, and fabricate convincing yet flawed reasoning. These aren't glitches; they expose how today's benchmarks reward test-taking… Continue reading The Illusion of #Readiness: Stress Testing Large Frontier Models on Multimodal #Medical Benchmarks
LBA 06 – Clinical Effectiveness of Single Course Low-Dose #Radiation Therapy in #Knee #Osteoarthritis: Short-term Results from the Randomized, Sham-Controlled Trial
Low-dose radiation therapy (LDRT) has been historically used as a non-pharmacologic option for osteoarthritis (OA), but solid evidence from randomized trials is still limited.Materials/Methods: In this multicenter, randomized, sham-controlled trial, 114 patients with knee OA were allocated to receive sham irradiation, total 0.3 Gy/6 fractions, or total 3 Gy/6 fractions. The main inclusion criteria are… Continue reading LBA 06 – Clinical Effectiveness of Single Course Low-Dose #Radiation Therapy in #Knee #Osteoarthritis: Short-term Results from the Randomized, Sham-Controlled Trial
Relative associations of #coffee, #tea, and plain #water with all-cause and cause-specific #mortality: a prospective cohort study
Previous studies have highlighted the health benefits of coffee and tea, but they only focused on the comparisons between different consumptions. Consequently, the association estimate lacked a clear interpretation, as the substitution of beverages and distribution of doses were not explicitly prescribed. We focused on the “relative association” to ascertain the optimal consumption strategy (including… Continue reading Relative associations of #coffee, #tea, and plain #water with all-cause and cause-specific #mortality: a prospective cohort study
Daily #Mango Intake Improves #Glycemic and Body Composition Outcomes in Adults with #Prediabetes: A Randomized Controlled Study
Background: Prediabetes is on the rise and can progress to type 2 diabetes and related cardiometabolic complications if left untreated. Nutrition plays a critical role in blood glucose regulation, and evaluating the effects of whole foods on indices of glycemic control and body composition within individuals with prediabetes is important. This study examined whether consuming… Continue reading Daily #Mango Intake Improves #Glycemic and Body Composition Outcomes in Adults with #Prediabetes: A Randomized Controlled Study
#Acupuncture appears to be a rapidly effective treatment for #costochondritis
BackgroundTo my knowledge, this is the first case series of costochondritis treated by acupuncture. Eight cases are presented, the majority being seen in primary care.Costochondritis is a debilitating condition characterised by severe anterior or lateral chest pain, associated with tenderness of the second to fifth costochondral (CC) joints. Tietze’s syndrome is a rare variant with… Continue reading #Acupuncture appears to be a rapidly effective treatment for #costochondritis
Very High Prevalence of Nonoptimally Controlled Traditional #Risk Factors at the Onset of #Cardiovascular Disease
BackgroundRecent studies suggest that coronary heart disease (CHD) may frequently occur in the absence of traditional cardiovascular disease (CVD) risk factors. However, it is unclear whether this could reflect missed clinical diagnoses or subthreshold nonoptimal risk factor exposure preceding CHD, and whether similar patterns are observed for heart failure (HF) or stroke.ObjectivesThe purpose of this… Continue reading Very High Prevalence of Nonoptimally Controlled Traditional #Risk Factors at the Onset of #Cardiovascular Disease
Monoclonal #antibodies protect against pandrug-resistant #Klebsiella pneumoniae
The ‘silent pandemic’ caused by antimicrobial resistance requires innovative therapeutic approaches. Human monoclonal antibodies (mAbs), which are among the most transformative and safe drugs in oncology1 and autoimmunity2, are rarely used for infectious diseases and not yet used for antimicrobial resistance3. Here we applied an antigen-agnostic strategy to isolate extremely potent human mAbs against Klebsiella… Continue reading Monoclonal #antibodies protect against pandrug-resistant #Klebsiella pneumoniae
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