Highlights•Compared to previous years, the amount and quality of acupuncture evidence has severely increased in the years 2017–2022.•Acupuncture showed evidence of positive effect for ten medical conditions and thus should be applied in clinical settings.•In most of the remaining 174 medical indications acupuncture showed some beneficial effects, no effect in six of them.•Overall, acupuncture is… Continue reading The state of #evidence in acupuncture: A #review of #metaanalyses and systematic reviews of acupuncture evidence (update 2017–2022)
Effect of Varying Quantities of Lean #Beef as Part of a #Mediterranean‐Style #Dietary Pattern on Gut #Microbiota and Plasma, Fecal, and Urinary Metabolites: A Randomized Crossover Controlled Feeding Trial
Consumption of trimethylamine N‐oxide (TMAO) precursors, such as carnitine found in lean beef, raises circulating TMAO concentrations; however, a healthy dietary pattern may attenuate these effects.MethodsThis randomized, 4‐period crossover, controlled‐feeding study investigated the effects of Mediterranean‐style (MED) diets (carbohydrate 42%, protein 17%, fat 41%) with 14 (MED0.5; 0.5 oz), 71 (MED2.5; 2.5 oz), and 156… Continue reading Effect of Varying Quantities of Lean #Beef as Part of a #Mediterranean‐Style #Dietary Pattern on Gut #Microbiota and Plasma, Fecal, and Urinary Metabolites: A Randomized Crossover Controlled Feeding Trial
#Coffee for the #liver: a mechanistic approach
The liver, which is essential for metabolism and detoxification, is vulnerable to various damaging factors, including viral infections, excessive alcohol consumption, and a diet high in fat and sugar. Coffee, one of the most widely consumed beverages worldwide, is valued not only for its flavor and aroma but also for its potential health benefits. In… Continue reading #Coffee for the #liver: a mechanistic approach
Progression to #rheumatoid arthritis in at-risk individuals is defined by systemic #inflammation and by T and B cell dysregulation
Rheumatoid arthritis (RA) is preceded by an at-risk stage of disease that can be marked by the presence of anticitrullinated protein antibodies (ACPAs) but the absence of clinically apparent synovitis (clinical RA). Preemptive intervention in at-risk individuals could prevent or delay future tissue damage; however, the immunobiology of this stage is unclear. Using integrative multiomics,… Continue reading Progression to #rheumatoid arthritis in at-risk individuals is defined by systemic #inflammation and by T and B cell dysregulation
Effect of #Metformin on the Risk of Post- #coronavirus Disease 2019 Condition Among Individuals With #Overweight or #Obese: A Population-based Retrospective Cohort Study
BackgroundA subgroup analysis of the COVID-OUT trial's long-term outcome found that starting metformin within 3 days of coronavirus disease 2019 (COVID-19) diagnosis reduced post–COVID-19 condition (PCC) incidence by 63% in overweight or obese individuals. However, its generalizability remains uncertain.ObjectivesTo evaluate the effectiveness of metformin in preventing PCC in adults with overweight or obesity who had… Continue reading Effect of #Metformin on the Risk of Post- #coronavirus Disease 2019 Condition Among Individuals With #Overweight or #Obese: A Population-based Retrospective Cohort Study
Unlocking deep #relaxation: the power of #rhythmic #breathing on brain rhythms
The pandemic has exacerbated mental health issues across the world. The limited availability of mental health professionals is preventing many from seeking help, which highlights the need for easily available mental health care routines like yoga, breathing, and meditation. A breath-based meditation technique known as Sudarshan Kriya #Yoga (SKY) harnesses the power of breath to… Continue reading Unlocking deep #relaxation: the power of #rhythmic #breathing on brain rhythms
Effects of 2-year #cocoa extract# supplementation on #inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trial Get access Arrow
ObjectiveTo examine the long-term effect of cocoa flavanols on inflammaging biomarkers in the COcoa Supplement and Multivitamin Outcomes Study (COSMOS).MethodsCOSMOS is a large, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial testing the effects of a cocoa extract supplement (containing 500 mg cocoa flavanols/day, including 80 mg (−)-epicatechin) among women aged ≥65 years and men aged ≥60… Continue reading Effects of 2-year #cocoa extract# supplementation on #inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trial Get access Arrow
Risk markers for sudden unexpected #death in #epilepsy: an observational, prospective, multicentre cohort study
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality. Generalised—particularly nocturnal—convulsive seizures, longstanding epilepsy, and solitary living have been identified retrospectively as risk factors. No definitive electroclinical biomarkers have been prospectively ascertained. This study aimed to identify SUDEP risk markers using multimodality data with long-term follow-up.MethodsThis prospective, multicentre, observational cohort study,… Continue reading Risk markers for sudden unexpected #death in #epilepsy: an observational, prospective, multicentre cohort study
#Nicotinamide for #Skin #Cancer Chemoprevention
Importance Nicotinamide supplementation has been studied as a chemopreventive medication for reducing skin cancer risk, but large-scale data are limited.Objective To determine the clinical efficacy of nicotinamide supplementation for skin cancer prevention in the general population and among solid organ transplant recipients.Design, Setting, and Participants A retrospective cohort study was conducted using electronic health record… Continue reading #Nicotinamide for #Skin #Cancer Chemoprevention
2 Medical News 