Dear Editor,Worldwide, around 55 million people had prevalent dementia in 2019, which is expected to triple by 2050, especially in low- and middle-income countries. Lacking timely diagnosis and limited effective treatment for dementia make identifying risk factors crucial for its early prevention, among which dietary factors have received increasing attention.Recently, accumulating evidence from population-based studies… Continue reading Temporal patterns of energy intake and cognitive function and its decline: a community-based cohort study in China
Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies
Evidence suggests that spironolactone, a nonselective mineralocorticoid receptor (MR) antagonist, modulates alcohol seeking and consumption. Therefore, spironolactone may represent a novel pharmacotherapy for alcohol use disorder (AUD). In this study, we tested the effects of spironolactone in a mouse model of alcohol drinking (drinking-in-the-dark) and in a rat model of alcohol dependence (vapor exposure). We… Continue reading Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies
Attention-deficit/hyperactivity disorder as a risk factor for cardiovascular diseases: a nationwide population-based cohort study
AbstractAccumulating evidence suggests a higher risk for cardiovascular diseases among individuals with mental disorders, but very little is known about the risk for overall and specific groups of cardiovascular diseases in people with attention-deficit/hyperactivity disorder (ADHD). To fill this knowledge gap, we investigated the prospective associations between ADHD and a wide range of cardiovascular diseases… Continue reading Attention-deficit/hyperactivity disorder as a risk factor for cardiovascular diseases: a nationwide population-based cohort study
Association of Combined Healthy Lifestyle Factors With Incident Dementia in Patients With Type 2 Diabetes
Background and Objectives: Type 2 diabetes and lifestyle factors have been associated with dementia risk, but the impact of a healthy lifestyle on diabetes-related dementia remains largely unknown. We aimed to investigate whether the increased risk of dementia among individuals with diabetes can be offset by a broad combination of healthy lifestyle factors.Methods: This prospective study utilized… Continue reading Association of Combined Healthy Lifestyle Factors With Incident Dementia in Patients With Type 2 Diabetes
Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction
Highlights•Innate immune system receptors/interferon/Stat1 axis triggers inflammaging•Both lifetime and short-time dietary restriction (DR) treatments ameliorate inflammaging•Transcriptome alteration caused by aging, lifetime, or short-term DR are tissue specific•Aging induces a general open chromatin rearrangement, which is not rescued by DRSummaryAging is characterized by a chronic low-grade inflammation known as inflammaging in multiple tissues, representing a risk… Continue reading Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction
Association of nut consumption with CVD risk factors in young to middle-aged adults: The Coronary Artery Risk Development in Young Adults (CARDIA) study
Highlights•Walnut and nut consumers had higher HEI2015 diet quality scores than those who do not consume nuts.•Walnut consumers had a better CVD risk profile than other nut and no nut consumers.•Our study findings support the health claim to include walnuts as part of a healthy diet.AbstractBackground and aimsFew studies have examined long-term associations of walnut,… Continue reading Association of nut consumption with CVD risk factors in young to middle-aged adults: The Coronary Artery Risk Development in Young Adults (CARDIA) study
Prospective Associations of Daily Step Counts and Intensity With Cancer and Cardiovascular Disease Incidence and Mortality and All-Cause Mortality
Recommendations for the number of steps per day may be easier to enact for some people than the current time- and intensity-based physical activity guidelines, but the evidence to support steps-based goals is limited.Objective To describe the associations of step count and intensity with all-cause mortality and cancer and cardiovascular disease (CVD) incidence and mortality.Design, Setting,… Continue reading Prospective Associations of Daily Step Counts and Intensity With Cancer and Cardiovascular Disease Incidence and Mortality and All-Cause Mortality
Association of Mental Health Burden With Prenatal Cannabis Exposure From Childhood to Early AdolescenceLongitudinal Findings From the Adolescent Brain Cognitive Development (ABCD) Study
Dramatic increases in cannabis use during pregnancy are alarming because of evidence that prenatal exposure may be associated with a host of adverse outcomes. We previously found that prenatal cannabis exposure (PCE) following maternal knowledge of pregnancy is associated with increased psychopathology during middle childhood using baseline data from the Adolescent Brain Cognitive Development (ABCD) study.Here,… Continue reading Association of Mental Health Burden With Prenatal Cannabis Exposure From Childhood to Early AdolescenceLongitudinal Findings From the Adolescent Brain Cognitive Development (ABCD) Study
Understanding the Pharmacology of COVID-19 mRNA Vaccines: Playing Dice with the Spike?
AbstractCoronavirus disease-19 (COVID-19) mRNA vaccines are the mainstays of mass vaccination campaigns in most Western countries. However, the emergency conditions in which their development took place made it impossible to fully characterize their effects and mechanism of action. Here, we summarize and discuss available evidence indicating that COVID-19 mRNA vaccines better reflect pharmaceutical drugs than… Continue reading Understanding the Pharmacology of COVID-19 mRNA Vaccines: Playing Dice with the Spike?
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