Severe coronavirus disease-2019 (COVID-19) can progress to an acute respiratory distress syndrome (ARDS), which involves alveolar infiltration by activated neutrophils. The beta-blocker metoprolol has been shown to ameliorate exacerbated inflammation in the myocardial infarction setting. ObjectivesThe purpose of this study was to evaluate the effects of metoprolol on alveolar inflammation and on respiratory function in… Continue reading #Metoprolol in Critically Ill Patients With COVID-19
Category: Pneumology
Sudden death in individuals with obstructive sleep #apnoea: a systematic review and meta-analysis
Over 1 billion individuals worldwide experience some form of sleep apnoea, and this number is steadily rising. Obstructive sleep apnoea (OSA) can negatively influence one’s quality of life and potentially increase mortality risk. However, the association between OSA and mortality has not been reliably estimated. This meta-analysis estimates the risk of all-cause and cardiovascular mortality in… Continue reading Sudden death in individuals with obstructive sleep #apnoea: a systematic review and meta-analysis
The noradrenergic agent reboxetine plus antimuscarinic hyoscine butylbromide reduces sleep #apnoea severity: A double-blind, placebo-controlled, randomised crossover trial
Recent animal and human physiology studies indicate that noradrenergic and muscarinic processes are key mechanisms that mediate pharyngeal muscle control during sleep. The noradrenergic agent reboxetine combined with the anti-muscarinic hyoscine butylbromide has recently been shown to improve upper airway function during sleep in healthy individuals. However, whether these findings translate to the clinically relevant… Continue reading The noradrenergic agent reboxetine plus antimuscarinic hyoscine butylbromide reduces sleep #apnoea severity: A double-blind, placebo-controlled, randomised crossover trial
Dynamic innate immune response determines susceptibility to #SARS-CoV-2 infection and early replication kinetics
Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish infection, and the replication levelcorrelates with the likelihood of viral transmission. Here, we examined the role of host innate immune defenses in restrictingearly SARS-CoV-2 infection using transcriptomics and biomarker-based tracking in serial patient nasopharyngeal samples andexperiments with airway epithelial organoids. SARS-CoV-2 initially… Continue reading Dynamic innate immune response determines susceptibility to #SARS-CoV-2 infection and early replication kinetics
Readmission following both #cardiac and non-cardiac acute #dyspnoea is associated with a striking risk of death
Readmission and mortality are the most common and often combined endpoints in acute heart failure (AHF) trials, but an association between these two outcomes is poorly investigated. The aim of this study was to determine whether unplanned readmission is associated with a greater subsequent risk of death in patients with acute dyspnoea due to cardiac… Continue reading Readmission following both #cardiac and non-cardiac acute #dyspnoea is associated with a striking risk of death
Sex differences in risk factors for #depressive symptoms in patients with #COPD: The 2014 and 2016 Korea National Health and Nutrition Examination Survey
Although depression is a common comorbidity of chronic obstructive pulmonary disease (COPD), the role of sex remains unexplored. We evaluated sex differences of risk factors of depressive symptoms in adults with COPD. MethodsThis was a population-based cross-sectional study using data from the 2014 and 2016 Korea National Health and Nutrition Examination Survey. Spirometry was used… Continue reading Sex differences in risk factors for #depressive symptoms in patients with #COPD: The 2014 and 2016 Korea National Health and Nutrition Examination Survey
The relationship between duration and quality of #sleep and upper #respiratory tract infections: a systematic review
Upper respiratory tract infections (URTIs) are common, mostly self-limiting, but result in inappropriate antibiotic prescriptions. Poor sleep is cited as a factor predisposing to URTIs, but the evidence is unclear. ObjectiveTo systematically review whether sleep duration and quality influence the frequency and duration of URTIs. MethodsThree databases and bibliographies of included papers were searched for… Continue reading The relationship between duration and quality of #sleep and upper #respiratory tract infections: a systematic review
Nasal High-flow €Oxygen Versus Conventional Oxygen Therapy for Acute Severe #Asthma Patients: A Pilot Randomized Controlled Trial
Nasal high flow (NHF) has demonstrated efficacy in relieving dyspnea in various patients with hypoxemic and hypercapnic respiratory failure. It may also reduce dyspnea in patients with acute severe asthma in the emergency department (ED). The aim of the study was to compare the efficacy of NHF with conventional oxygen therapy (COT) in improving dyspnea… Continue reading Nasal High-flow €Oxygen Versus Conventional Oxygen Therapy for Acute Severe #Asthma Patients: A Pilot Randomized Controlled Trial
Indices of #Diet Quality and Risk of Lung #Cancer in the Women’s Health Initiative Observational Study
Prospective evidence on associations between diet quality indices and lung cancer risk is limited, particularly among older women. ObjectivesWe investigated associations between 4 diet quality indices [Healthy Eating Index-2015 (HEI-2015), Alternate Healthy Eating Index 2010 (AHEI-2010), alternate Mediterranean Diet (aMED), and Dietary Approaches to Stop Hypertension (DASH)] and lung cancer incidence and mortality in the… Continue reading Indices of #Diet Quality and Risk of Lung #Cancer in the Women’s Health Initiative Observational Study
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