Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish infection, and the replication levelcorrelates with the likelihood of viral transmission. Here, we examined the role of host innate immune defenses in restrictingearly SARS-CoV-2 infection using transcriptomics and biomarker-based tracking in serial patient nasopharyngeal samples andexperiments with airway epithelial organoids. SARS-CoV-2 initially… Continue reading Dynamic innate immune response determines susceptibility to #SARS-CoV-2 infection and early replication kinetics
Category: Pneumology
Readmission following both #cardiac and non-cardiac acute #dyspnoea is associated with a striking risk of death
Readmission and mortality are the most common and often combined endpoints in acute heart failure (AHF) trials, but an association between these two outcomes is poorly investigated. The aim of this study was to determine whether unplanned readmission is associated with a greater subsequent risk of death in patients with acute dyspnoea due to cardiac… Continue reading Readmission following both #cardiac and non-cardiac acute #dyspnoea is associated with a striking risk of death
Sex differences in risk factors for #depressive symptoms in patients with #COPD: The 2014 and 2016 Korea National Health and Nutrition Examination Survey
Although depression is a common comorbidity of chronic obstructive pulmonary disease (COPD), the role of sex remains unexplored. We evaluated sex differences of risk factors of depressive symptoms in adults with COPD. MethodsThis was a population-based cross-sectional study using data from the 2014 and 2016 Korea National Health and Nutrition Examination Survey. Spirometry was used… Continue reading Sex differences in risk factors for #depressive symptoms in patients with #COPD: The 2014 and 2016 Korea National Health and Nutrition Examination Survey
The relationship between duration and quality of #sleep and upper #respiratory tract infections: a systematic review
Upper respiratory tract infections (URTIs) are common, mostly self-limiting, but result in inappropriate antibiotic prescriptions. Poor sleep is cited as a factor predisposing to URTIs, but the evidence is unclear. ObjectiveTo systematically review whether sleep duration and quality influence the frequency and duration of URTIs. MethodsThree databases and bibliographies of included papers were searched for… Continue reading The relationship between duration and quality of #sleep and upper #respiratory tract infections: a systematic review
Nasal High-flow €Oxygen Versus Conventional Oxygen Therapy for Acute Severe #Asthma Patients: A Pilot Randomized Controlled Trial
Nasal high flow (NHF) has demonstrated efficacy in relieving dyspnea in various patients with hypoxemic and hypercapnic respiratory failure. It may also reduce dyspnea in patients with acute severe asthma in the emergency department (ED). The aim of the study was to compare the efficacy of NHF with conventional oxygen therapy (COT) in improving dyspnea… Continue reading Nasal High-flow €Oxygen Versus Conventional Oxygen Therapy for Acute Severe #Asthma Patients: A Pilot Randomized Controlled Trial
Indices of #Diet Quality and Risk of Lung #Cancer in the Women’s Health Initiative Observational Study
Prospective evidence on associations between diet quality indices and lung cancer risk is limited, particularly among older women. ObjectivesWe investigated associations between 4 diet quality indices [Healthy Eating Index-2015 (HEI-2015), Alternate Healthy Eating Index 2010 (AHEI-2010), alternate Mediterranean Diet (aMED), and Dietary Approaches to Stop Hypertension (DASH)] and lung cancer incidence and mortality in the… Continue reading Indices of #Diet Quality and Risk of Lung #Cancer in the Women’s Health Initiative Observational Study
Mammalian enteral #ventilation ameliorates respiratory failure
Enteral ventilation (EVA) enabled systemic oxygenation in mammaliansEVA improved survival and behaviors in pre-clinical models of respiratory failureEVA yielded no major signs of complications in pre-clinical modelsEVA may serve as a transformative approach in respiratory failure patients Context and significanceThe SARS-CoV-2 pandemic has overwhelmed the clinical need for ventilators and artificial lungs, resulting in a… Continue reading Mammalian enteral #ventilation ameliorates respiratory failure
The oral #microbiome in early #rheumatoid arthritis patients and individuals at risk differs from healthy controls
It has been suggested that rheumatoid arthritis (RA) may originate at the oral mucosa. Our aim was to assess the oral microbiome and the periodontal condition in patients with early rheumatoid arthritis (ERA) and individuals at risk of RA. MethodsThree groups were recruited (50 participants each): (1) ERA patients (2010 ACR/EULAR criteria), (2) at‐risk individuals… Continue reading The oral #microbiome in early #rheumatoid arthritis patients and individuals at risk differs from healthy controls
Delayed #antibiotic prescribing for #respiratory tract infections: individual patient data meta-analysis
To assess the overall effect of delayed antibiotic prescribing on average symptom severity for patients with respiratory tract infections in the community, and to identify any factors modifying this effect. Design Systematic review and individual patient data meta-analysis. Data sources Cochrane Central Register of Controlled Trials, Ovid Medline, Ovid Embase, EBSCO CINAHL Plus, and Web… Continue reading Delayed #antibiotic prescribing for #respiratory tract infections: individual patient data meta-analysis
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