Poor sleep quality in patients with chronic obstructive pulmonary disease (#COPD ) has been associated with poor health outcomes. However, there is a lack of research on factors associated with sleep disturbance in patients with COPD.. This was a prospective, multicenter cross‐sectional study enrolling a sample of 245 COPD subjects. All patients completed the patient‐reported… Continue reading Factors associated with #sleep disturbance in patients with chronic #obstructive pulmonary disease
Category: Pneumology
Sex-specific associations between #erythrocyte measures and obstructive #sleep apnea
STUDY OBJECTIVES:Hypoxemic effects of obstructive sleep apnea (OSA) have been implicated in changes in erythropoiesis and hence erythrocyte measures. Sex differences are evident in both OSA and erythropoiesis. Whether sex modulates the relationship between severity of OSA and erythrocyte measures has not previously been studied.. ..RESULTS:In multiple regression models, we found significant interactions between sex… Continue reading Sex-specific associations between #erythrocyte measures and obstructive #sleep apnea
Acute pulmonary #embolism in patients with obstructive #sleep apnea: frequency, hospital outcomes, and recurrence
The objectives of this study were to assess the effect of obstructive sleep apnea (OSA) on the risk of acute pulmonary embolism (PE), hospital outcomes including mortality, and PE recurrence.. ..Of 25,038 patients, 3,184 (13%) had OSA and 283 (1.1%) experienced PE. Frequency of PE in patients with and without OSA was 2.4% versus 0.9%… Continue reading Acute pulmonary #embolism in patients with obstructive #sleep apnea: frequency, hospital outcomes, and recurrence
Initiating Pharmacologic Treatment in #Tobacco-Dependent Adults. An Official American Thoracic Society Clinical Practice Guideline
Current tobacco treatment guidelines have established the efficacy of available interventions, but they do not provide detailed guidance for common implementation questions frequently faced in the clinic. An evidence-based guideline was created that addresses several pharmacotherapy-initiation questions that routinely confront treatment teams.. ..The guideline panel formulated five strong recommendations and two conditional recommendations regarding pharmacotherapy… Continue reading Initiating Pharmacologic Treatment in #Tobacco-Dependent Adults. An Official American Thoracic Society Clinical Practice Guideline
Association Between Oral Corticosteroid Bursts and Severe Adverse Events
Long-term use of oral corticosteroids has known adverse effects, but the risk from brief oral steroid bursts (≤14 days) is largely unknown.. .. Background: Long-term use of oral corticosteroids has known adverse effects, but the risk from brief oral steroid bursts (≤14 days) is largely unknown. Objective: To examine the associations between steroid bursts and… Continue reading Association Between Oral Corticosteroid Bursts and Severe Adverse Events
Circular Dichroism Spectroscopy Identifies the β-Adrenoceptor Agonist Salbutamol As a Direct Inhibitor of Tau Filament Formation in Vitro
Potential drug treatments for Alzheimer’s disease (AD) may be found by identifying compounds that block the assembly of the microtubule-associated protein tau into neurofibrillar tangles associated with neuron destabilization and cell death. Here, a small library of structurally diverse compounds was screened in vitro for the ability to inhibit tau aggregation, using high-throughput synchrotron radiation… Continue reading Circular Dichroism Spectroscopy Identifies the β-Adrenoceptor Agonist Salbutamol As a Direct Inhibitor of Tau Filament Formation in Vitro
Effect of beta-blockers on survival of lung cancer patients: a systematic review and meta-analysis
The recent interest in beta-blockers as possible agents for drug repurposing in oncology arises from many pre-clinical and epidemiologic studies suggesting a possible clinically relevant antitumour effect. In lung cancer, given the contradictory results obtained, it is crucial to further study its effects. A systematic review of the literature was planned to evaluate a possible… Continue reading Effect of beta-blockers on survival of lung cancer patients: a systematic review and meta-analysis
ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19
Patients who died from COVID-19 often had comorbidities, such as hypertension, diabetes, and chronic obstructive lung disease. Although angiotensin-converting enzyme 2 (ACE2) is crucial for SARS-CoV2 to bind and enter host cells, no study has systematically assessed the ACE2 expression in the lungs of patients with these diseases. Here, we analyzed over 700 lung transcriptome… Continue reading ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19
Association of Obstructive Sleep Apnea with Nighttime Blood Pressure in African Americans: the Jackson Heart Study
Obstructive sleep apnea (OSA), nocturnal hypertension, and non-dipping systolic blood pressure (BP) are each highly prevalent among African Americans. However, few data are available on the association between OSA and nighttime BP in this population.. ..Among 206 participants who completed ABPM and participated in the Jackson Heart Sleep Study, 50.5% had nocturnal hypertension and 26.2%… Continue reading Association of Obstructive Sleep Apnea with Nighttime Blood Pressure in African Americans: the Jackson Heart Study
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