Changes in gut microbiota composition have been linked to anxiety behavior in rodents. However, the underlying neural circuitry linking microbiota and their metabolites to anxiety behavior remains unknown. Using male C57BL/6J germ-free (GF) mice, not exposed to live microbes, increased anxiety-related behavior was observed correlating with a significant increase in the immediate early c-Fos gene… Continue reading Microbial metabolites tune #amygdala neuronal hyperexcitability and #anxiety-linked behaviors
Category: Neurology
Salt Substitution and Recurrent #Stroke and DeathA Randomized Clinical Trial
Question Does the use of a reduced-sodium, added-potassium salt substitute vs regular salt decrease the risk of stroke recurrence and death in patients with a history of stroke?Findings In this prespecified subgroup analysis of the Salt Substitute and Stroke Study (SSaSS) trial involving 15 249 patients with stroke, the use of a salt substitute led… Continue reading Salt Substitution and Recurrent #Stroke and DeathA Randomized Clinical Trial
Propagation of pathologic α-synuclein from #kidney to brain may contribute to #Parkinson’s disease
The pathogenesis of Lewy body diseases (LBDs), including Parkinson’s disease (PD), involves α-synuclein (α-Syn) aggregation that originates in peripheral organs and spreads to the brain. PD incidence is increased in individuals with chronic renal failure, but the underlying mechanisms remain unknown. Here we observed α-Syn deposits in the kidneys of patients with LBDs and in… Continue reading Propagation of pathologic α-synuclein from #kidney to brain may contribute to #Parkinson’s disease
Oral #microbiome and nitric oxide biomarkers in older people with mild #cognitive impairment and APOE4 genotype
AbstractApolipoprotein E4 (APOE4) genotype and nitric oxide (NO) deficiency are risk factors for age-associated cognitive decline. The oral microbiome plays a critical role in maintaining NO bioavailability during aging. The aim of this study was to assess interactions between the oral microbiome, NO biomarkers, and cognitive function in 60 participants with mild cognitive impairment (MCI)… Continue reading Oral #microbiome and nitric oxide biomarkers in older people with mild #cognitive impairment and APOE4 genotype
Association of rapid eye movement #sleep latency with multimodal biomarkers of #Alzheimer’s disease
Sleep disturbances are associated with Alzheimer's disease (AD) and Alzheimer's disease and related dementias (ADRD), but the relationship between sleep architecture, particularly rapid eye movement (REM) sleep, and AD/ADRD biomarkers remains unclear.METHODSWe enrolled 128 adults (64 with Alzheimer's disease, 41 with mild cognitive impairment [MCI], and 23 with normal cognition [NC]), mean age 70.8 ±… Continue reading Association of rapid eye movement #sleep latency with multimodal biomarkers of #Alzheimer’s disease
Long-Term Effect of Intensive vs Standard Blood #Pressure Control on Mild Cognitive Impairment and Probable #Dementia in SPRINT
Background and ObjectivesThe Systolic Blood Pressure Intervention Trial suggested that intensive lowering of systolic blood pressure (SBP) decreases the risk of developing dementia. However, an insufficient number of probable dementia cases stemming from the trial's early termination made results inconclusive. The goal of this study was to estimate the effect of intensive vs standard SBP… Continue reading Long-Term Effect of Intensive vs Standard Blood #Pressure Control on Mild Cognitive Impairment and Probable #Dementia in SPRINT
The Neurologist’s Role in Promoting #Brain Health
Neurologic conditions are a leading cause of morbidity and mortality within the United States and worldwide. Brain health is a global concern, and the American Academy of Neurology's Brain Health Initiative promises to drive progress in this field over the next decades. Neurologists with detailed training and insight into brain function are uniquely positioned to… Continue reading The Neurologist’s Role in Promoting #Brain Health
#Retinal vascular fingerprints predict incident #stroke: findings from the UK Biobank cohort study
Objective To investigate the associations between a comprehensive set of retinal vascular parameters and incident stroke to unveil new associations and explore its predictive power for stroke risk.Methods Retinal vascular parameters were extracted from the UK Biobank fundus images using the Retina-based Microvascular Health Assessment System. We used Cox regression analysis, adjusted for traditional risk… Continue reading #Retinal vascular fingerprints predict incident #stroke: findings from the UK Biobank cohort study
#Green tea consumption and #cerebral white matter lesions in community-dwelling older adults without dementia
This study investigated the association between green tea or coffee consumption with cerebral white matter lesions and hippocampal and total brain volumes among 8766 community-dwelling participants recruited from the Japan Prospective Studies Collaboration for Aging and Dementia between 2016 and 2018. A Food Frequency Questionnaire was used to assess green tea and coffee consumption, whereas… Continue reading #Green tea consumption and #cerebral white matter lesions in community-dwelling older adults without dementia
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