Importance Epidemiological studies suggest that lifestyle factors are associated with risk of dementia. However, few studies have examined the association of diet and waist to hip ratio (WHR) with hippocampus connectivity and cognitive health.Objective To ascertain how longitudinal changes in diet quality and WHR during midlife are associated with hippocampal connectivity and cognitive function in… Continue reading Association of #Diet and #Waist-to-Hip Ratio With Brain Connectivity and #Memory in #Aging
Category: Neurology
#Cognitive Decline After First-Time Transient #Ischemic Attack
Question When controlling for vascular and demographic factors, does transient ischemic attack confer an independent risk for cognitive decline?Findings In this longitudinal cohort study (Reasons for Geographic and Racial Differences in Stroke [REGARDS]), pre-event and postevent cognitive trajectories were compared in 356 individuals with TIA, 965 individuals with stroke, and 14 882 asymptomatic controls. A single,… Continue reading #Cognitive Decline After First-Time Transient #Ischemic Attack
Microbial metabolites tune #amygdala neuronal hyperexcitability and #anxiety-linked behaviors
Changes in gut microbiota composition have been linked to anxiety behavior in rodents. However, the underlying neural circuitry linking microbiota and their metabolites to anxiety behavior remains unknown. Using male C57BL/6J germ-free (GF) mice, not exposed to live microbes, increased anxiety-related behavior was observed correlating with a significant increase in the immediate early c-Fos gene… Continue reading Microbial metabolites tune #amygdala neuronal hyperexcitability and #anxiety-linked behaviors
Salt Substitution and Recurrent #Stroke and DeathA Randomized Clinical Trial
Question Does the use of a reduced-sodium, added-potassium salt substitute vs regular salt decrease the risk of stroke recurrence and death in patients with a history of stroke?Findings In this prespecified subgroup analysis of the Salt Substitute and Stroke Study (SSaSS) trial involving 15 249 patients with stroke, the use of a salt substitute led… Continue reading Salt Substitution and Recurrent #Stroke and DeathA Randomized Clinical Trial
Propagation of pathologic α-synuclein from #kidney to brain may contribute to #Parkinson’s disease
The pathogenesis of Lewy body diseases (LBDs), including Parkinson’s disease (PD), involves α-synuclein (α-Syn) aggregation that originates in peripheral organs and spreads to the brain. PD incidence is increased in individuals with chronic renal failure, but the underlying mechanisms remain unknown. Here we observed α-Syn deposits in the kidneys of patients with LBDs and in… Continue reading Propagation of pathologic α-synuclein from #kidney to brain may contribute to #Parkinson’s disease
Oral #microbiome and nitric oxide biomarkers in older people with mild #cognitive impairment and APOE4 genotype
AbstractApolipoprotein E4 (APOE4) genotype and nitric oxide (NO) deficiency are risk factors for age-associated cognitive decline. The oral microbiome plays a critical role in maintaining NO bioavailability during aging. The aim of this study was to assess interactions between the oral microbiome, NO biomarkers, and cognitive function in 60 participants with mild cognitive impairment (MCI)… Continue reading Oral #microbiome and nitric oxide biomarkers in older people with mild #cognitive impairment and APOE4 genotype
Association of rapid eye movement #sleep latency with multimodal biomarkers of #Alzheimer’s disease
Sleep disturbances are associated with Alzheimer's disease (AD) and Alzheimer's disease and related dementias (ADRD), but the relationship between sleep architecture, particularly rapid eye movement (REM) sleep, and AD/ADRD biomarkers remains unclear.METHODSWe enrolled 128 adults (64 with Alzheimer's disease, 41 with mild cognitive impairment [MCI], and 23 with normal cognition [NC]), mean age 70.8 ±… Continue reading Association of rapid eye movement #sleep latency with multimodal biomarkers of #Alzheimer’s disease
Long-Term Effect of Intensive vs Standard Blood #Pressure Control on Mild Cognitive Impairment and Probable #Dementia in SPRINT
Background and ObjectivesThe Systolic Blood Pressure Intervention Trial suggested that intensive lowering of systolic blood pressure (SBP) decreases the risk of developing dementia. However, an insufficient number of probable dementia cases stemming from the trial's early termination made results inconclusive. The goal of this study was to estimate the effect of intensive vs standard SBP… Continue reading Long-Term Effect of Intensive vs Standard Blood #Pressure Control on Mild Cognitive Impairment and Probable #Dementia in SPRINT
The Neurologist’s Role in Promoting #Brain Health
Neurologic conditions are a leading cause of morbidity and mortality within the United States and worldwide. Brain health is a global concern, and the American Academy of Neurology's Brain Health Initiative promises to drive progress in this field over the next decades. Neurologists with detailed training and insight into brain function are uniquely positioned to… Continue reading The Neurologist’s Role in Promoting #Brain Health
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