Epidemiological, preclinical, and clinical studies have suggested a role for microdose lithium in reducing Alzheimer’s disease (AD) risk by modulating key mechanisms associated with AD pathology. The novel microdose lithium formulation, NP03, has disease-modifying effects in the McGill-R-Thy1-APP transgenic rat model of AD-like amyloidosis at pre-plaque stages, before frank amyloid-β (Aβ) plaque deposition, during which… Continue reading NP03, a Microdose #Lithium Formulation, Blunts Early #Amyloid Post-Plaque Neuropathology in McGill-R-Thy1-APP Alzheimer-Like Transgenic Rats
Category: Neurology
A randomized, double-blind, placebo-controlled trial of blue wavelength light exposure on sleep and recovery of brain structure, function, and cognition following mild traumatic brain injury
Sleep and circadian rhythms are among the most powerful but least understood contributors to cognitive performance and brain health. Here we capitalize on the circadian resetting effect of blue-wavelength light to phase shift the sleep patterns of adult patients (aged 18–48 years) recovering from mild traumatic brain injury (mTBI), with the aim of facilitating recovery… Continue reading A randomized, double-blind, placebo-controlled trial of blue wavelength light exposure on sleep and recovery of brain structure, function, and cognition following mild traumatic brain injury
Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
Recent discoveries have implicated the gut #microbiome in the progression and severity of #Parkinson’s disease; however, how gut bacteria affect such neurodegenerative disorders remains unclear. Here, we report that the Bacillus subtilis probiotic strain PXN21 inhibits α-synuclein aggregation and clears preformed aggregates in an established Caenorhabditis elegans model of synucleinopathy. This protection is seen in… Continue reading Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
Estimated #Stroke-Free Survival of #Folic Acid Therapy for Hypertensive Adults
The CSPPT (China Stroke Primary Prevention Trial) demonstrated a significant risk reduction of first stroke in hypertensive patients treated with enalapril plus folic acid compared with those with enalapril alone, but the lifetime stroke-free survival associated with the treatment is unknown.. ..Compared with enalapril alone, the enalapril plus folic acid treatment projected a mean lifetime… Continue reading Estimated #Stroke-Free Survival of #Folic Acid Therapy for Hypertensive Adults
The Risk of Head #Injuries Associated With Antipsychotic Use Among Persons With #Alzheimer’s disease
Antipsychotic use is associated with risk of falls among older persons, but we are not aware of previous studies investigating risk of head injuries. We studied the association of antipsychotic use and risk of head injuries among community dwellers with Alzheimer's disease (AD) ..Antipsychotic use was associated with an increased risk of head injuries (event… Continue reading The Risk of Head #Injuries Associated With Antipsychotic Use Among Persons With #Alzheimer’s disease
Adrenergic Signaling in #Muscularis Macrophages Limits Infection-Induced Neuronal Loss
..Enteric-associated neurons (EANs) are closely associated with immune cells and continuously monitor and modulate homeostatic intestinal functions, including motility and nutrient sensing. Bidirectional interactions between neuronal and immune cells are altered during disease processes such as neurodegeneration or #irritable bowel syndrome. We investigated the effects of infection-induced inflammation on intrinsic EANs (iEANs) and the role… Continue reading Adrenergic Signaling in #Muscularis Macrophages Limits Infection-Induced Neuronal Loss
#cognitive performance in relation to #hydration status and water intake among older adults, NHANES 2011–2014
..we tested if calculated serum osmolarity (Sosm) and adequate intake (AI) of water among women (n = 1271) and men (n = 1235) ≥ 60 years old were associated with scores of immediate and delayed recall, verbal fluency, and attention/processing speed. Sosm was categorized as < 285 (hyperhydrated), 285–289, 290–294, 295–300, or > 300 (dehydrated) mmol/L. AI of water was defined as ≥ 2 L/day for women… Continue reading #cognitive performance in relation to #hydration status and water intake among older adults, NHANES 2011–2014
Association between ambient fine #particulate pollution and hospital admissions for cause specific #cardiovascular disease: time series study in 184 major Chinese cities
..At the national average level, an increase of 10 μg/m3 in PM2.5 was associated with a 0.26% (95% confidence interval 0.17% to 0.35%) increase in hospital admissions on the same day for cardiovascular disease, 0.31% (0.22% to 0.40%) for ischaemic heart disease, 0.27% (0.04% to 0.51%) for heart failure, 0.29% (0.12% to 0.46%) for heart… Continue reading Association between ambient fine #particulate pollution and hospital admissions for cause specific #cardiovascular disease: time series study in 184 major Chinese cities
Nightly #sleep duration, fragmentation, and quality and daily risk of #migraine
..migraine onset on the day immediately following the sleep period (day 0) and the following day (day 1). ..Sleep duration ≤6.5 hours and poor sleep quality were not associated with migraine on day 0 or day 1. Diary-reported low efficiency was associated with 39% higher odds of headache on day 1 (odds ratio [OR] 1.39,… Continue reading Nightly #sleep duration, fragmentation, and quality and daily risk of #migraine
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