... A total of 666,333 men, 70,608 brothers, and 7388 twin brothers born 1939–1959 and examined at the conscript board were followed in Danish nationwide registers (1969–2016). Cox regression models were applied to analyze the association between body height and dementia. Within-brothers and within-twin pair analyses were conducted to explore the role of shared familial… Continue reading Body #height in young adult men and risk of #dementia later in adult life
Category: Neurology
Efficacy and Safety of #Lanabecestat for Treatment of Early and Mild #Alzheimer Disease
Does lanabecestat, a potent inhibitor of the beta-site amyloid precursor protein–cleaving enzyme 1 (BACE1), slow the progression of early Alzheimer disease (AD) and mild AD dementia?.. ..Among 1722 DAYBREAK-ALZ patients, the mean (SD) age was 72.3 (7.0) years, and 1023 of 1722 (59.4%) were women. Both studies were terminated early after futility analysis. There were… Continue reading Efficacy and Safety of #Lanabecestat for Treatment of Early and Mild #Alzheimer Disease
How #odor cues help to optimize #learning during sleep in a real life-setting
Effortless learning during sleep is everybody’s dream. Several studies found that presenting odor cues during learning and selectively during slow wave sleep increases learning success.. ..We (1) performed a field study of vocabulary-learning in a regular school setting, (2) stimulated with odor cues during the whole night without sleep monitoring, and (3) applied the odor… Continue reading How #odor cues help to optimize #learning during sleep in a real life-setting
Effects of #Caffeine and Acute Aerobic #Exercise on Working Memory and Caffeine Withdrawal
Studies show that a single bout of exercise confers cognitive benefits. However, many individuals use psychoactive substances such as caffeine to enhance cognitive performance.. The objectives of this study were to compare the effects of acute moderate intensity aerobic exercise to caffeine on working memory (WM) and caffeine withdrawal symptoms (CWS). In Phase I, non-caffeine… Continue reading Effects of #Caffeine and Acute Aerobic #Exercise on Working Memory and Caffeine Withdrawal
Five-Year Outcomes of Transcatheter or Surgical #Aortic-Valve Replacement
..At 5 years, there was no significant difference in the incidence of death from any cause or disabling stroke between the TAVR group and the surgery group (47.9% and 43.4%, respectively; hazard ratio, 1.09; 95% confidence interval [CI], 0.95 to 1.25; P=0.21). Results were similar for the transfemoral-access cohort (44.5% and 42.0%, respectively; hazard ratio,… Continue reading Five-Year Outcomes of Transcatheter or Surgical #Aortic-Valve Replacement
NP03, a Microdose #Lithium Formulation, Blunts Early #Amyloid Post-Plaque Neuropathology in McGill-R-Thy1-APP Alzheimer-Like Transgenic Rats
Epidemiological, preclinical, and clinical studies have suggested a role for microdose lithium in reducing Alzheimer’s disease (AD) risk by modulating key mechanisms associated with AD pathology. The novel microdose lithium formulation, NP03, has disease-modifying effects in the McGill-R-Thy1-APP transgenic rat model of AD-like amyloidosis at pre-plaque stages, before frank amyloid-β (Aβ) plaque deposition, during which… Continue reading NP03, a Microdose #Lithium Formulation, Blunts Early #Amyloid Post-Plaque Neuropathology in McGill-R-Thy1-APP Alzheimer-Like Transgenic Rats
A randomized, double-blind, placebo-controlled trial of blue wavelength light exposure on sleep and recovery of brain structure, function, and cognition following mild traumatic brain injury
Sleep and circadian rhythms are among the most powerful but least understood contributors to cognitive performance and brain health. Here we capitalize on the circadian resetting effect of blue-wavelength light to phase shift the sleep patterns of adult patients (aged 18–48 years) recovering from mild traumatic brain injury (mTBI), with the aim of facilitating recovery… Continue reading A randomized, double-blind, placebo-controlled trial of blue wavelength light exposure on sleep and recovery of brain structure, function, and cognition following mild traumatic brain injury
Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
Recent discoveries have implicated the gut #microbiome in the progression and severity of #Parkinson’s disease; however, how gut bacteria affect such neurodegenerative disorders remains unclear. Here, we report that the Bacillus subtilis probiotic strain PXN21 inhibits α-synuclein aggregation and clears preformed aggregates in an established Caenorhabditis elegans model of synucleinopathy. This protection is seen in… Continue reading Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans
Estimated #Stroke-Free Survival of #Folic Acid Therapy for Hypertensive Adults
The CSPPT (China Stroke Primary Prevention Trial) demonstrated a significant risk reduction of first stroke in hypertensive patients treated with enalapril plus folic acid compared with those with enalapril alone, but the lifetime stroke-free survival associated with the treatment is unknown.. ..Compared with enalapril alone, the enalapril plus folic acid treatment projected a mean lifetime… Continue reading Estimated #Stroke-Free Survival of #Folic Acid Therapy for Hypertensive Adults
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