Worldwide, the prevalence of dementia is increasing and diet as a modifiable factor could play a role. Meat consumption has been cross-sectionally associated with dementia risk, but specific amounts and types related to risk of incident dementia remain poorly understood. Objective We aimed to investigate associations between meat consumption and risk of incident dementia in… Continue reading #Meat consumption and risk of incident #dementia: cohort study of 493,888 UK Biobank participants
Category: Neurology
Post-reversible cerebral vasoconstriction syndrome #headache
Chronic headache may persist after the remission of reversible cerebral vasoconstriction syndrome (RCVS) in some patients. We aimed to investigate the prevalence, characteristics, risk factors, and the impact of post-RCVS headache. Methods We prospectively recruited patients with RCVS and collected their baseline demographics, including psychological distress measured by Hospital Anxiety and Depression scale. We evaluated… Continue reading Post-reversible cerebral vasoconstriction syndrome #headache
A Primary Care Agenda for #Brain Health: A Scientific Statement From the American Heart Association
A healthy brain is critical for living a longer and fuller life. The projected aging of the population, however, raises new challenges in maintaining quality of life. As we age, there is increasing compromise of neuronal activity that affects functions such as cognition, also making the brain vulnerable to disease. Once pathology-induced decline begins, few… Continue reading A Primary Care Agenda for #Brain Health: A Scientific Statement From the American Heart Association
A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent #glioblastoma
Glioblastoma (GBM) is one of the most difficult cancers to effectively treat, in part because of the lack of precision therapies and limited therapeutic access to intracranial tumor sites due to the presence of the blood-brain and blood-tumor barriers. We have developed a precision medicine approach for GBM treatment that involves the use of brain-penetrant… Continue reading A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent #glioblastoma
#Olfactory dysfunction predicts the development of #dementia in older patients with type 2 #diabetes
Olfactory dysfunction is associated with the transition from normal cognition to dementia in persons without type 2 diabetes. This study aimed to investigate whether olfactory dysfunction could be an early marker of future dementia in older patients with type 2 diabetes. Methods This exploratory study included 151 older Japanese outpatients with type 2 diabetes who… Continue reading #Olfactory dysfunction predicts the development of #dementia in older patients with type 2 #diabetes
Prevalence of Central Nervous System–Active Polypharmacy Among Older Adults With #Dementia in the US
Community-dwelling older adults with dementia have a high prevalence of psychotropic and opioid use. In these patients, central nervous system (CNS)–active polypharmacy may increase the risk for impaired cognition, fall-related injury, and death. Objective To determine the extent of CNS-active polypharmacy among community-dwelling older adults with dementia in the US. Design, Setting, and Participants Cross-sectional… Continue reading Prevalence of Central Nervous System–Active Polypharmacy Among Older Adults With #Dementia in the US
Clinical and Biological Correlates of White Matter Hyperintensities in Patients with #Behavioral-variant Frontotemporal #Dementia and #Alzheimer Disease
To test the hypothesis that white matter hyperintensities (WMH) in behavioral-variant frontotemporal dementia (bvFTD) and Alzheimer disease (AD) are associated with disease variables such as disease severity, cortical atrophy and cognition, we conducted a cross-sectional brain MRI study with volumetric and voxel-wise analyses. Methods: 129 patients (64 bvFTD, 65 AD) and 66 controls underwent high-resolution… Continue reading Clinical and Biological Correlates of White Matter Hyperintensities in Patients with #Behavioral-variant Frontotemporal #Dementia and #Alzheimer Disease
#Physical activity may not be associated with long‐term risk of #dementia and #Alzheimer’s disease
While it is well established that physical activity is associated with reduced risk of vascular and nonvascular outcomes as well as mortality, evidence on the association between physical activity and dementia is inconsistent. We aimed to assess the associations of physical activity with the risk of dementia and Alzheimer's disease (AD). Material and methods We… Continue reading #Physical activity may not be associated with long‐term risk of #dementia and #Alzheimer’s disease
Early peripheral activity alters nascent subplate circuits in the #auditory cortex
Cortical function can be shaped by sensory experience during a critical period. The onset of the critical period is thought to coincide with the onset of thalamocortical transmission to the thalamo-recipient layer 4 (L4). In early development, subplate neurons (SPNs), and not L4 neurons, are the first targets of thalamic afferents. SPNs are transiently involved… Continue reading Early peripheral activity alters nascent subplate circuits in the #auditory cortex
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