Several lines of study suggest that peripheral metabolism of amyloid beta (Aß) is associated with risk for Alzheimer disease (AD). In blood, greater than 90% of Aß is complexed as an apolipoprotein, raising the possibility of a lipoprotein-mediated axis for AD risk. In this study, we report that genetic modification of C57BL/6J mice engineered to… Continue reading Synthesis of human #amyloid restricted to #liver results in an #Alzheimer disease–like neurodegenerative phenotype
Category: Neurology
Spatial organization of #protein aggregates on red #blood cells as physical biomarkers of #Alzheimer’s disease pathology
Quantifying physical differences of protein aggregates implicated in Alzheimer’s disease (AD), in blood, could provide crucial information on disease stages. Here, red blood cells (RBCs) from 50 patients with neurocognitive complaints and 16 healthy individuals were profiled using an atomic force microscope (AFM). AFM measurements revealed patient age– and stage of neurocognitive disorder–dependent differences in… Continue reading Spatial organization of #protein aggregates on red #blood cells as physical biomarkers of #Alzheimer’s disease pathology
Role and Mechanism of Gut #Microbiota in Human #Disease
The human gut microbiome is a huge microbial community that plays an irreplaceable role in human life. With the further development of research, the influence of intestinal flora on human diseases has been gradually excavated. Gut microbiota (GM) dysbiosis has adverse health effects on the human body that will lead to a variety of chronic… Continue reading Role and Mechanism of Gut #Microbiota in Human #Disease
Analysis of Features of #Alzheimer’s Disease: Detection of Early Stage from Functional Brain Changes in Magnetic #Resonance Images Using a Finetuned ResNet18 Network
One of the first signs of Alzheimer’s disease (AD) is mild cognitive impairment (MCI), in which there are small variants of brain changes among the intermediate stages. Although there has been an increase in research into the diagnosis of AD in its early levels of developments lately, brain changes, and their complexity for functional magnetic… Continue reading Analysis of Features of #Alzheimer’s Disease: Detection of Early Stage from Functional Brain Changes in Magnetic #Resonance Images Using a Finetuned ResNet18 Network
Associations of #ophthalmic and systemic conditions with incident #dementia in the UK Biobank
To examine independent and interactive associations of ophthalmic and systemic conditions with incident dementia. Methods: Our analysis included 12 364 adults aged 55-73 years from the UK Biobank cohort. Participants were assessed between 2006 and 2010 at baseline and were followed up until the early of 2021. Incident dementia was ascertained using hospital inpatient, death… Continue reading Associations of #ophthalmic and systemic conditions with incident #dementia in the UK Biobank
Residential exposure to transportation #noise in Denmark and incidence of #dementia: national cohort study
To investigate the association between long term residential exposure to road traffic and railway noise and risk of incident dementia. Design Nationwide prospective register based cohort study. Setting Denmark. Participants 1 938 994 adults aged ≥60 years living in Denmark between 1 January 2004 and 31 December 2017. Main outcome measures Incident cases of all cause dementia… Continue reading Residential exposure to transportation #noise in Denmark and incidence of #dementia: national cohort study
#Screen time and early adolescent #mental health, academic, and social outcomes in 9- and 10- year old children: Utilizing the Adolescent Brain #Cognitive Development ℠ (ABCD) Study
In a technology-driven society, screens are being used more than ever. The high rate of electronic media use among children and adolescents begs the question: is screen time harming our youth? The current study draws from a nationwide sample of 11,875 participants in the United States, aged 9 to 10 years, from the Adolescent Brain… Continue reading #Screen time and early adolescent #mental health, academic, and social outcomes in 9- and 10- year old children: Utilizing the Adolescent Brain #Cognitive Development ℠ (ABCD) Study
Observing changes in human functioning during induced #sleep deficiency and recovery periods
Prolonged periods of sleep restriction seem to be common in the contemporary world. Sleep loss causes perturbations of circadian rhythmicity and degradation of waking alertness as reflected in attention, cognitive efficiency and memory. Understanding whether and how the human brain recovers from chronic sleep loss is important not only from a scientific but also from… Continue reading Observing changes in human functioning during induced #sleep deficiency and recovery periods
#Cognitive stimulation in the workplace, plasma proteins, and risk of #dementia: three analyses of population cohort studies
To examine the association between cognitively stimulating work and subsequent risk of dementia and to identify protein pathways for this association. Design Multicohort study with three sets of analyses. Setting United Kingdom, Europe, and the United States. Participants Three associations were examined: cognitive stimulation and dementia risk in 107 896 participants from seven population based prospective… Continue reading #Cognitive stimulation in the workplace, plasma proteins, and risk of #dementia: three analyses of population cohort studies
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