Obstructive sleep apnea (OSA) is a chronic prevalent condition characterized by intermittent hypoxia (IH) and sleep fragmentation (SF). Evidence suggests that OSA can alter the gut microbiome (GM) diversity and composition that may then promote the occurrence of some of the OSA-associated morbidities. However, it is unclear whether perturbations in the GM caused by IH… Continue reading Fecal #microbiota transplantation from mice exposed to chronic intermittent hypoxia elicits #sleep disturbances in naïve mice
Category: Neurology
Circuit-specific enteric #glia regulate #intestinal motor neurocircuits
Neurons have long been considered the main active cell type within the circuitry of the enteric nervous system (ENS), giving rise to a neurocentric paradigm that has tended to overlook the role of enteric glia as key regulators of gut motility. Understanding how simple synapse-level interactions give rise to complex, network-level behaviors remains a fundamental… Continue reading Circuit-specific enteric #glia regulate #intestinal motor neurocircuits
Total #sleep deprivation reduces top-down regulation of #emotion without altering bottom-up affective processing
Sleep loss is reported to influence affective processing, causing changes in overall mood and altering emotion regulation. These aspects of affective processing are seldom investigated together, making it difficult to determine whether total sleep deprivation has a global effect on how affective stimuli and emotions are processed, or whether specific components of affective processing are… Continue reading Total #sleep deprivation reduces top-down regulation of #emotion without altering bottom-up affective processing
Optimal Blood #Pressure Keeps Our #Brains Younger
Elevated blood pressure (BP) is a major health risk factor and the leading global cause of premature death. Hypertension is also a risk factor for cognitive decline and dementia. However, when elevated blood pressure starts impacting cerebral health is less clear. We addressed this gap by estimating how a validated measure of brain health relates… Continue reading Optimal Blood #Pressure Keeps Our #Brains Younger
#Depressive Symptoms Imputed Across the Life Course Are Associated with #Cognitive Impairment and Cognitive Decline
Depressive symptoms may increase risk for dementia, but findings are controversial because late-life depression may be a prodromal dementia symptom. Life course data on depression and dementia risk may clarify this association; however, data is limited. Objective: To impute adult depressive symptoms trajectories across adult life stages and estimate the association with cognitive impairment and… Continue reading #Depressive Symptoms Imputed Across the Life Course Are Associated with #Cognitive Impairment and Cognitive Decline
Synthesis of human #amyloid restricted to #liver results in an #Alzheimer disease–like neurodegenerative phenotype
Several lines of study suggest that peripheral metabolism of amyloid beta (Aß) is associated with risk for Alzheimer disease (AD). In blood, greater than 90% of Aß is complexed as an apolipoprotein, raising the possibility of a lipoprotein-mediated axis for AD risk. In this study, we report that genetic modification of C57BL/6J mice engineered to… Continue reading Synthesis of human #amyloid restricted to #liver results in an #Alzheimer disease–like neurodegenerative phenotype
Spatial organization of #protein aggregates on red #blood cells as physical biomarkers of #Alzheimer’s disease pathology
Quantifying physical differences of protein aggregates implicated in Alzheimer’s disease (AD), in blood, could provide crucial information on disease stages. Here, red blood cells (RBCs) from 50 patients with neurocognitive complaints and 16 healthy individuals were profiled using an atomic force microscope (AFM). AFM measurements revealed patient age– and stage of neurocognitive disorder–dependent differences in… Continue reading Spatial organization of #protein aggregates on red #blood cells as physical biomarkers of #Alzheimer’s disease pathology
Role and Mechanism of Gut #Microbiota in Human #Disease
The human gut microbiome is a huge microbial community that plays an irreplaceable role in human life. With the further development of research, the influence of intestinal flora on human diseases has been gradually excavated. Gut microbiota (GM) dysbiosis has adverse health effects on the human body that will lead to a variety of chronic… Continue reading Role and Mechanism of Gut #Microbiota in Human #Disease
Analysis of Features of #Alzheimer’s Disease: Detection of Early Stage from Functional Brain Changes in Magnetic #Resonance Images Using a Finetuned ResNet18 Network
One of the first signs of Alzheimer’s disease (AD) is mild cognitive impairment (MCI), in which there are small variants of brain changes among the intermediate stages. Although there has been an increase in research into the diagnosis of AD in its early levels of developments lately, brain changes, and their complexity for functional magnetic… Continue reading Analysis of Features of #Alzheimer’s Disease: Detection of Early Stage from Functional Brain Changes in Magnetic #Resonance Images Using a Finetuned ResNet18 Network
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