One of the hallmarks of Alzheimer’s disease (AD) are deposits of amyloid-beta (Aβ) protein in amyloid plaques in the brain. The Aβ peptide exists in several forms, including full-length Aβ1-42 and Aβ1-40 – and the N-truncated species, pyroglutamate Aβ3-42 and Aβ4-42, which appear to play a major role in neurodegeneration. We previously identified a murine… Continue reading Discovery of a novel pseudo β-hairpin structure of N-truncated amyloid-β for use as a vaccine against Alzheimer’s disease
Category: Neurology
Serum Nonesterified #Fatty Acids and Incident #Stroke: The CHS
Significant associations between total nonesterified fatty acid (NEFA) concentrations and incident stroke have been reported in some prospective cohort studies. We evaluated the associations between incident stroke and serum concentrations of nonesterified saturated, monounsaturated, polyunsaturated, and trans fatty acids. Methods and ResultsCHS (Cardiovascular Health Study) participants (N=2028) who were free of stroke at baseline (1996–1997)… Continue reading Serum Nonesterified #Fatty Acids and Incident #Stroke: The CHS
Estimating dose-response relationships for vitamin #D with #coronary heart disease, #stroke, and all-cause mortality: observational and Mendelian randomisation analyses
SummaryBackgroundRandomised trials of vitamin D supplementation for cardiovascular disease and all-cause mortality have generally reported null findings. However, generalisability of results to individuals with low vitamin D status is unclear. We aimed to characterise dose-response relationships between 25-hydroxyvitamin D (25[OH]D) concentrations and risk of coronary heart disease, stroke, and all-cause mortality in observational and Mendelian… Continue reading Estimating dose-response relationships for vitamin #D with #coronary heart disease, #stroke, and all-cause mortality: observational and Mendelian randomisation analyses
Role of Adipocyte Na,K-ATPase Oxidant Amplification Loop in #Cognitive Decline and #Neurodegeneration
•Adipocytes induce phenotypical changes in neurodegeneration through adipocyte NKAL.•Adipocyte specific NaKtide inhibited NKAL and improved systemic homeostasis.•NaKtide improved adipocyte phenotype and improved markers of neurodegeneration.•NaKtide improved genomic profile of hippocampus and adipose tissue in WD fed mice. SummaryRecent studies suggest that a western diet may contribute to clinical neurodegeneration and dementia. Adipocyte-specific expression of the… Continue reading Role of Adipocyte Na,K-ATPase Oxidant Amplification Loop in #Cognitive Decline and #Neurodegeneration
Digging for data: How #sleep is losing out to roster design, sleep disorders, and lifestyle factors
Highlights•Shift start times <06:00, may result in sleep loss resulting in poor alertness. •Risk of sleep disorders increased with body mass and age. •Prevalence of shiftwork disorder and obstructive sleep apnea in mining is high. •Biomathematical modeling may be used to eliminate or reduce organizational risk. AbstractShift workers employed at a remote mining operation may… Continue reading Digging for data: How #sleep is losing out to roster design, sleep disorders, and lifestyle factors
Study: People Are Getting #Dumber
IQ scores have been steadily falling for decades, but genes aren't to blame – their environment is at fault. New research published this week in Proceedings of the National Academy of the Sciences of the United States of America examined the IQ scores of men born between 1962 and 1991. Researchers found that scores increased… Continue reading Study: People Are Getting #Dumber
Identification of a choroid plexus vascular barrier closing during #intestinal inflammation
Locking down access to the brainInflammatory bowel disease is best known for intestinal symptoms but can also cause a variety of extraintestinal manifestations in other organs. It can also be associated with cognitive and psychiatric effects, including anxiety and depression. Using mouse models of intestinal inflammation, Carloni et al. uncovered a potential pathogenic link between… Continue reading Identification of a choroid plexus vascular barrier closing during #intestinal inflammation
Dietary #DHA prevents cognitive impairment and inflammatory gene expression in aged male rats fed a diet enriched with refined #carbohydrates
•A processed-foods diet (PD) impaired learning and memory in aged male rats. •PD increased inflammatory genes in the hippocampus and amygdala of aged rats. •DHA supplementation prevented memory deficits in PD-fed aged rats. •DHA supplementation ameliorated increases in inflammatory gene expression. •PD consumption led to increased weight gain in young and aged rats. AbstractThe consumption… Continue reading Dietary #DHA prevents cognitive impairment and inflammatory gene expression in aged male rats fed a diet enriched with refined #carbohydrates
All-cause and cause-specific mortality in people with #mental disorders and intellectual disabilities, before and during the COVID-19 pandemic: cohort study
People with mental disorders and intellectual disabilities experience excess mortality compared with the general population. The impact of COVID-19 on exacerbating this, and in widening ethnic inequalities, is unclear. METHODSProspective data (N=167,122) from a large mental healthcare provider in London, UK, with deaths from 2019 to 2020, used to assess age- and gender-standardised mortality ratios… Continue reading All-cause and cause-specific mortality in people with #mental disorders and intellectual disabilities, before and during the COVID-19 pandemic: cohort study
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