AbstractBackground and objectives: Although flavonoids have the potential to exert neuroprotective benefits, evidence of their role in improving survival rates among individuals with Parkinson disease (PD) remains lacking. We aimed to prospectively study the association between pre- and post-diagnosis flavonoid intakes and risk of mortality among individuals with PD identified from two large ongoing cohorts… Continue reading Intake of Flavonoids and Flavonoid-Rich Foods, and Mortality Risk Among Individuals With Parkinson Disease: A Prospective Cohort Study
Category: Neurology
Evaluation of Adiposity and Cognitive Function in Adults
Excess adipose tissue increases other cardiovascular risk factors, which may be associated with vascular brain injury and cognitive impairment. However, the extent to which the amount and distribution of adipose tissue may be associated with lower cognitive scores, independent of its association with cardiovascular risk factors, is not well characterized. Objective To investigate the association… Continue reading Evaluation of Adiposity and Cognitive Function in Adults
Air quality improvement and cognitive decline in community-dwelling older women in the United States: A longitudinal cohort study
Late-life exposure to ambient air pollution is a modifiable risk factor for dementia, but epidemiological studies have shown inconsistent evidence for cognitive decline. Air quality (AQ) improvement has been associated with improved cardiopulmonary health and decreased mortality, but to the best of our knowledge, no studies have examined the association with cognitive function. We examined… Continue reading Air quality improvement and cognitive decline in community-dwelling older women in the United States: A longitudinal cohort study
Intranasal ketamine for acute cluster headache attacks—Results from a proof-of-concept open-label trial
ObjectiveTo investigate the safety and efficacy of intranasal ketamine for the treatment of a single cluster headache (CH) attack. BackgroundAcute treatment options for patients with CH who have an insufficient response to oxygen and triptans are limited. Intranasal ketamine has anecdotally been successful in treating a CH attack. MethodsWe conducted an open-label pilot study enrolling… Continue reading Intranasal ketamine for acute cluster headache attacks—Results from a proof-of-concept open-label trial
Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer’s Disease
With increasing life span and prevalence of dementia, it is important to understand the mechanisms of cognitive aging. Here, we focus on a subgroup of the population we term “cognitively frail,” defined by reduced cognitive function in the absence of subjective memory complaints, or a clinical diagnosis of dementia. Cognitive frailty is distinct from cognitive… Continue reading Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer’s Disease
Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019
SummaryBackgroundGiven the projected trends in population ageing and population growth, the number of people with dementia is expected to increase. In addition, strong evidence has emerged supporting the importance of potentially modifiable risk factors for dementia. Characterising the distribution and magnitude of anticipated growth is crucial for public health planning and resource prioritisation. This study… Continue reading Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019
Frailty, lifestyle, genetics and dementia risk
To optimise dementia prevention strategies, we must understand the complex relationships between lifestyle behaviours, frailty and genetics. Methods We explored relationships between frailty index, healthy lifestyle and polygenic risk scores (all assessed at study entry) and incident all-cause dementia as recorded on hospital admission records and death register data. Results The analytical sample had a… Continue reading Frailty, lifestyle, genetics and dementia risk
Impact of changing school start times on parent sleep
To examine the impact of changing school start times on sleep in parents of students in elementary, middle, and high school. MethodsAnnual surveys were completed by parents of K-12 students (n = 8190-10,592 per year) before (pre-change) and for 2 years (post-change, follow-up) after implementation of new school start times (elementary school [ES]: 60 minutes… Continue reading Impact of changing school start times on parent sleep
Aerobic exercise alters brain function and structure in Parkinson’s disease a randomized controlled trial
Randomized clinical trials have shown that aerobic exercise attenuates motor symptom progression in Parkinson's disease, but the underlying neural mechanisms are unclear. Here, we investigated how aerobic exercise influences disease-related functional and structural changes in the cortico-striatal sensorimotor network, which is involved in the emergence of motor deficits in Parkinson's disease. Additionally, we explored effects… Continue reading Aerobic exercise alters brain function and structure in Parkinson’s disease a randomized controlled trial
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