SummaryBackgroundGiven the projected trends in population ageing and population growth, the number of people with dementia is expected to increase. In addition, strong evidence has emerged supporting the importance of potentially modifiable risk factors for dementia. Characterising the distribution and magnitude of anticipated growth is crucial for public health planning and resource prioritisation. This study… Continue reading Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019
Category: Neurology
Frailty, lifestyle, genetics and dementia risk
To optimise dementia prevention strategies, we must understand the complex relationships between lifestyle behaviours, frailty and genetics. Methods We explored relationships between frailty index, healthy lifestyle and polygenic risk scores (all assessed at study entry) and incident all-cause dementia as recorded on hospital admission records and death register data. Results The analytical sample had a… Continue reading Frailty, lifestyle, genetics and dementia risk
Impact of changing school start times on parent sleep
To examine the impact of changing school start times on sleep in parents of students in elementary, middle, and high school. MethodsAnnual surveys were completed by parents of K-12 students (n = 8190-10,592 per year) before (pre-change) and for 2 years (post-change, follow-up) after implementation of new school start times (elementary school [ES]: 60 minutes… Continue reading Impact of changing school start times on parent sleep
Aerobic exercise alters brain function and structure in Parkinson’s disease a randomized controlled trial
Randomized clinical trials have shown that aerobic exercise attenuates motor symptom progression in Parkinson's disease, but the underlying neural mechanisms are unclear. Here, we investigated how aerobic exercise influences disease-related functional and structural changes in the cortico-striatal sensorimotor network, which is involved in the emergence of motor deficits in Parkinson's disease. Additionally, we explored effects… Continue reading Aerobic exercise alters brain function and structure in Parkinson’s disease a randomized controlled trial
The efficacy and tolerability of pharmacologically active interventions for alcohol-induced hangover symptomatology: A systematic review of the evidence from randomised placebo-controlled trials
To compare quantitatively the efficacy and tolerability of pharmacologically active interventions in the treatment and prevention of alcohol-induced hangover. MethodsSystematic review of placebo-controlled randomised trials in healthy adults that evaluated any pharmacologically active intervention in the treatment or prevention of hangover. We searched Medline, Embase, PsycINFO and CENTRAL from database inception until 1st August 2021.… Continue reading The efficacy and tolerability of pharmacologically active interventions for alcohol-induced hangover symptomatology: A systematic review of the evidence from randomised placebo-controlled trials
Post-SARS-CoV-2 vaccination venous sinus thrombosis: a literature review of 308 cases
There is accumulating evidence that SARS-CoV-2 vaccinations can be complicated by venous sinus thrombosis (VST). This review aimed at summarising and discussing previous and recent advances regarding the diagnosis, pathogenesis, treatment, and outcome of post-SARS-CoV-2 vaccination VST. At least 308 patients with post-SARS-CoV-2 vaccination VST have been reported as per the end of July 2021.… Continue reading Post-SARS-CoV-2 vaccination venous sinus thrombosis: a literature review of 308 cases
Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function
Glial cells are essential for functionality of the nervous system. Growing evidence underscores the importance of astrocytes; however, analogous astroglia in peripheral organs are poorly understood. Using confocal time-lapse imaging, fate mapping, and mutant genesis in a zebrafish model, we identify a neural crest–derived glial cell, termed nexus glia, which utilizes Meteorin signaling via Jak/Stat3… Continue reading Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function
Probiotics for Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Accumulating evidence from animal studies supports the potential role of probiotics and prebiotics in alleviating neurodegenerative diseases. However, whether dietary supplementation with probiotics improves cognitive function in patients with Alzheimer’s disease (AD) or mild cognitive impairment (MCI) is unclear. We searched literature databases for relevant randomized control trials and compared the outcomes between control/placebo and… Continue reading Probiotics for Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Sensory-Tactile Functional Mapping and Use-Associated Structural Variation of the Human Female Genital Representation Field
The precise location of the human female genital representation field in the primary somatosensory cortex (S1) is controversial and its capacity for use-associated structural variation as a function of sexual behavior remains unknown. We used an fMRI-compatible sensory-tactile stimulation paradigm to functionally map the location of the female genital representation field in 20 adult women.… Continue reading Sensory-Tactile Functional Mapping and Use-Associated Structural Variation of the Human Female Genital Representation Field
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