AbstractIntroductionOne of the rare but potentially serious side effects of COVID-19 vaccination is arterial and venous thrombosis. Acute ischemic stroke (AIS) cases have been reported post COVID-19 vaccination. Herein, we systematically reviewed the reported cases of AIS after COVID-19 vaccination.MethodThis systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses… Continue reading Acute ischemic stroke and vaccine-induced immune thrombotic thrombocytopenia post COVID-19 vaccination; a systematic review
Category: Neurology
Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer’s disease among women
Variants in the tau gene (MAPT) region are associated with breast cancer in women and Alzheimer's disease (AD) among persons lacking apolipoprotein E ε4 (ε4–). MethodsTo identify novel genes associated with tau-related pathology, we conducted two genome-wide association studies (GWAS) for AD, one among 10,340 ε4– women in the Alzheimer's Disease Genetics Consortium (ADGC) and… Continue reading Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer’s disease among women
Tourism as a dementia treatment based on positive psychology
AbstractNo research in tourism or medicine has addressed the potential relationship between travel and the medical treatment of dementia. Given tourism's increasingly important role in society, a cross-disciplinary team of tourism and dementia experts provide insight into the potential benefits of tourism for individuals with dementia. This conceptual effort critically reviews the tourism and dementia… Continue reading Tourism as a dementia treatment based on positive psychology
Creutzfeldt-Jakob Disease After the COVID-19Vaccination
Reports of neurological problems are increasing for the clinical presentation of COVID-19 The clinical presentation reported in this study seemed to be a combination of nonspecificcomplications of the systemic disease, inflammation of the cerebrovascular system, and theeffects of a direct viral infection. Creutzfeldt–Jakob disease, a spongiform encephalopathycaused by prions, is characterized by a severe neurological… Continue reading Creutzfeldt-Jakob Disease After the COVID-19Vaccination
Passage of exogeneous fine particles from the lung into the brain in humans and animals
There are still significant knowledge gaps in understanding the intrusion and retention of exogeneous particles into the central nervous system (CNS). Here, we uncovered various exogeneous fine particles in human cerebrospinal fluids (CSFs) and identified the ambient environmental or occupational exposure sources of these particles, including commonly found particles (e.g., Fe- and Ca-containing ones) and… Continue reading Passage of exogeneous fine particles from the lung into the brain in humans and animals
Distressing dreams and risk of Parkinson’s disease: A population-based cohort study
BackgroundParkinson's disease (PD) is associated with alterations to the phenomenology of dreaming - including an increased frequency of distressing dreams. Whether distressing dreams may precede the development of PD is unknown. This study investigated the association between frequent distressing dreams and the risk of incident PD.Methods3818 men aged 67 years or older from the Osteoporotic… Continue reading Distressing dreams and risk of Parkinson’s disease: A population-based cohort study
Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model
Elevation of soluble wild-type (WT) tau occurs in synaptic compartments in Alzheimer’s disease. We addressed whether tau elevation affects synaptic transmission at the calyx of Held in slices from mice brainstem. Whole-cell loading of WT human tau (h-tau) in presynaptic terminals at 10–20 µM caused microtubule (MT) assembly and activity-dependent rundown of excitatory neurotransmission. Capacitance… Continue reading Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model
Vitamin D and brain health: an observational and Mendelian randomization study
BackgroundHigher vitamin D status has been suggested to have beneficial effects on the brain. ObjectivesTo investigate the association between 25-hydroxyvitamin D [25(OH)D], neuroimaging features, and the risk of dementia and stroke. MethodsWe used prospective data from the UK Biobank (37–73 y at baseline) to examine the association between 25(OH)D concentrations with neuroimaging outcomes (N =… Continue reading Vitamin D and brain health: an observational and Mendelian randomization study
A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease
BackgroundAlzheimer’s disease, the most common cause of dementia, causes a progressive and irreversible deterioration of cognition that can sometimes be difficult to diagnose, leading to suboptimal patient care. MethodsWe developed a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted MRI scans, with or without cognitive scores. For each patient, a biomarker called… Continue reading A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease
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