Multiple sclerosis is a chronic immune-mediated disease of the brain and spinal cord resulting in physical and cognitive impairment in young adults. It is hypothesized that a disrupted bacterial and viral gut microbiota is a part of the pathogenesis mediating disease impact through an altered gut microbiota-brain axis. The aim of this study is to… Continue reading The gut microbiota in multiple sclerosis varies with disease activity
Category: Neurology
Associations of serum zinc, copper, and selenium with sleep disorders in the American adults: Data from NHANES 2011–2016
BackgroundEven though various studies have been conducted to investigate the relationship between trace metals and sleep, few epidemiological studies have evaluated the relationship between trace metals and sleep disorders in American adults.ObjectiveThis study intended to evaluate the associations of serum zinc (Zn), copper (Cu), selenium (Se), Zn/Cu, Zn/Se, and Cu/Se ratios with sleep disorders in… Continue reading Associations of serum zinc, copper, and selenium with sleep disorders in the American adults: Data from NHANES 2011–2016
Reported sleep duration reveals segmentation of the adult life-course into three phases
Classically the human life-course is characterized by youth, middle age and old age. A wide range of biological, health and cognitive functions vary across this life-course. Here, using reported sleep duration from 730,187 participants across 63 countries, we find three distinct phases in the adult human life-course: early adulthood (19-33yrs), mid-adulthood (34-53yrs), and late adulthood… Continue reading Reported sleep duration reveals segmentation of the adult life-course into three phases
Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer’s disease pathology
The role of microglia in tau accumulation is currently unclear but could provide an important insight into the mechanisms underlying Alzheimer’s disease (AD)1. Here, we measured the microglial marker soluble TREM2 and the disease-associated microglial activation stage 2 markers AXL, MERTK, GAS6, LPL, CST7, SPP1 and CSF1 in nondemented individuals from the Swedish BioFINDER-2 cohort… Continue reading Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer’s disease pathology
Association of Dietary Intake of Flavonols With Changes in Global Cognition and Several Cognitive Abilities
APOE-ɛ4, late life cognitive activity, physical activity, and smoking, total flavonol intake was associated with slower decline in global cognition β estimate=0.004 (95% CI=0.001, 0.006), episodic memory β=0.004 (95% CI: 0.002, 0.006), semantic memory β=0.003 (95% CI: 0.001, 0.007), perceptual speed β=0.003 (95% CI: 0.001, 0.004), and working memory β=0.003 (95% CI: 0.001, 0.005) and… Continue reading Association of Dietary Intake of Flavonols With Changes in Global Cognition and Several Cognitive Abilities
Association of Maternal Preeclampsia With Offspring Risks of Ischemic Heart Disease and Stroke in Nordic Countries
Importance An association between maternal preeclampsia and an increased risk of cardiovascular disease in the offspring is plausible, but evidence in this area is limited.Objective To investigate (1) the association between maternal preeclampsia and risks of ischemic heart disease (IHD) and stroke in the offspring, (2) whether the association varies by severity or timing of onset of… Continue reading Association of Maternal Preeclampsia With Offspring Risks of Ischemic Heart Disease and Stroke in Nordic Countries
Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk
Chlamydia pneumoniae is a respiratory tract pathogen but can also infect the central nervous system (CNS). Recently, the link between C. pneumoniae CNS infection and late-onset dementia has become increasingly evident. In mice, CNS infection has been shown to occur weeks to months after intranasal inoculation. By isolating live C. pneumoniae from tissues and using immunohistochemistry, we show that C. pneumoniae can… Continue reading Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk
Zinc ions prevent α-synuclein aggregation by enhancing chaperone function of human serum albumin
Metal ions present in cellular microenvironment have been implicated as drivers of aggregation of amyloid forming proteins. Zinc (Zn2+) ions have been reported to directly interact with α-synuclein (AS), a causative agent of Parkinson's disease and other neurodegenerative diseases, and promote its aggregation. AS is a small intrinsically disordered protein (IDP) i.e., understanding molecular factors… Continue reading Zinc ions prevent α-synuclein aggregation by enhancing chaperone function of human serum albumin
Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey
AbstractObjectiveThe purpose of this study was to identify the prevalence of severe headache or migraine and the association between dietary thiamine and riboflavin intake with headache history using a large, nationally representative population sample.BackgroundSevere headache and migraine are common and disabling neurological disorders worldwide. Previous studies revealed that the B vitamin group, as an important… Continue reading Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey
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