Alzheimer’s disease (AD) pathologies were discovered in the accessible neurosensory retina. However, their exact nature and topographical distribution, particularly in the early stages of functional impairment, and how they relate to disease progression in the brain remain largely unknown. To better understand the pathological features of AD in the retina, we conducted an extensive histopathological… Continue reading Retinal pathological features and proteome signatures of Alzheimer’s disease
Category: Neurology
Association of Bone Mineral Density and Dementia: The Rotterdam Study
Background & Objective: Low bone mineral density and dementia commonly co-occur in the elderly, with bone loss accelerating in dementia patients due to physical inactivity and poor nutrition. However, uncertainty persists over the extent to which bone loss already exists prior to the onset of dementia. Therefore, we investigated how dementia risk was affected by… Continue reading Association of Bone Mineral Density and Dementia: The Rotterdam Study
Influence of poor sleep on cardiovascular disease-free life expectancy: a multi-resource-based population cohort study
The complexity of sleep hinders the formulation of sleep guidelines. Recent studies suggest that different unhealthy sleep characteristics jointly increase the risks for cardiovascular disease (CVD). This study aimed to estimate the differences in CVD-free life expectancy between people with different sleep profiles.MethodsWe included 308,683 middle-aged adults from the UK Biobank among whom 140,181 had… Continue reading Influence of poor sleep on cardiovascular disease-free life expectancy: a multi-resource-based population cohort study
Depressive Symptoms and Risk of Acute Stroke: INTERSTROKE Case-Control Study
Depression has been reported to be a risk factor for acute stroke, based largely on studies in high-income countries. In the INTERSTROKE study, we explored the contribution of depressive symptoms to acute stroke risk and 1-month outcome across regions of the world, within subpopulations and by stroke typeMethodsINTERSTROKE is an international case-control study of risk… Continue reading Depressive Symptoms and Risk of Acute Stroke: INTERSTROKE Case-Control Study
Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin
Declining nicotinamide adenine dinucleotide (NAD+) concentration in the brain during aging contributes to metabolic and cellular dysfunction and is implicated in the pathogenesis of aging-associated neurological disorders. Experimental therapies aimed at boosting brain NAD+ levels normalize several neurodegenerative phenotypes in animal models, motivating their clinical translation. Dietary intake of NAD+ precursors, such as nicotinamide riboside… Continue reading Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin
Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status
IntroductionDespite the association of vitamin D deficiency with incident dementia, the role of supplementation is unclear. We prospectively explored associations between vitamin D supplementation and incident dementia in 12,388 dementia-free persons from the National Alzheimer's Coordinating Center.MethodsBaseline exposure to vitamin D was considered D+; no exposure prior to dementia onset was considered D−. Kaplan–Meier curves… Continue reading Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status
Obesity impacts the expression of Alzheimer’s disease–related genes: The Framingham Heart Study
IntroductionWe investigated associations of obesity with the expression of Alzheimer's disease (AD)–related genes in a large community-based cohort.MethodsThe sample consisted of 5619 participants from the Framingham Heart Study. Obesity metrics included body mass index (BMI) and waist-to-hip ratio (WHR). Gene expression was measured for a set of 74 AD-related genes, derived by integrating genome-wide association… Continue reading Obesity impacts the expression of Alzheimer’s disease–related genes: The Framingham Heart Study
Association between insomnia and the incidence of myocardial infarction: A systematic review and meta-analysis
BackgroundInsomnia has been closely associated with cardiovascular disease (CVD) including myocardial infarction (MI). Our study aims to assess the eligibility of insomnia as a potential risk factor for MI.MethodsPubMed, Scopus, and Web of Science were searched using terms; such as “Insomnia” and “MI.” Only observational controlled studies with data on the incidence of MI among… Continue reading Association between insomnia and the incidence of myocardial infarction: A systematic review and meta-analysis
Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences
PurposeTo examine the association between dietary magnesium (Mg) intake and brain volumes and white matter lesions (WMLs) in middle to early old age.MethodsParticipants (aged 40–73 years) from UK Biobank (n = 6001) were included and stratified by sex. Dietary Mg was measured using an online computerised 24 h recall questionnaire to estimate daily Mg intake. Latent class… Continue reading Dietary magnesium intake is related to larger brain volumes and lower white matter lesions with notable sex differences
2 Medical News 