Little is known about the benefits of statin therapy in older adults with dementia. We aimed to evaluate the role of statin use for all-cause mortality in nursing home residents with and without dementia.MethodsThis retrospective cohort study used claims data collected between January 2015 and December 2019 from a German health and long-term care insurance… Continue reading Statin Use and All-Cause Mortality in Nursing Home Residents With and Without DementiaA Retrospective Cohort Study Using Claims Data
Category: Neurology
Summary: A new study explores the molecular connections between Type 2 #diabetes and #Alzheimer’s, supporting the notion of Alzheimer’s as “Type 3 diabetes.”
This study finds that a high-fat diet suppresses a crucial gut protein, Jak3, leading to Alzheimer’s-like brain changes in mice. It underscores the importance of managing diabetes or avoiding it through diet to reduce Alzheimer’s risk.The findings illuminate a potential path from diet through gut inflammation to brain health, offering hope for preventative strategies.Key Facts:Molecular… Continue reading Summary: A new study explores the molecular connections between Type 2 #diabetes and #Alzheimer’s, supporting the notion of Alzheimer’s as “Type 3 diabetes.”
#Diet, Pace of Biological #Aging, and Risk of #Dementia in the Framingham Heart Study
AbstractObjectivePeople who eat healthier diets are less likely to develop dementia, but the biological mechanism of this protection is not well understood. We tested the hypothesis that healthy diet protects against dementia because it slows the pace of biological aging.MethodsWe analyzed Framingham Offspring Cohort data. We included participants ≥60 years-old, free of dementia and having dietary,… Continue reading #Diet, Pace of Biological #Aging, and Risk of #Dementia in the Framingham Heart Study
Curve #Walking Reveals More #Gait Impairments in Older Adults with Mild #Cognitive Impairment than Straight Walking: A Kinect Camera-Based Study
Background:Mild cognitive impairment (MCI) can be an early sign of Alzheimer’s disease and other types of dementia detectable through gait analysis. Curve walking, which demands greater cognitive and motor skills, may be more sensitive in MCI detection than straight walking. However, few studies have compared gait performance in older adults with and without MCI in… Continue reading Curve #Walking Reveals More #Gait Impairments in Older Adults with Mild #Cognitive Impairment than Straight Walking: A Kinect Camera-Based Study
Sleep #Apnea and Incident #Stroke in a National Cohort of Black and White Adults
Background and ObjectivesRacial/ethnic differences have been documented in the relationship between obstructive sleep apnea (OSA) and stroke incidence, yet racial differences in OSA symptoms or treatment and their relationship with stroke incidence are underexplored and may contribute to stroke disparities. We comprehensively examined OSA symptoms and their relationships to stroke incidence by race/ethnicity.MethodsData were collected… Continue reading Sleep #Apnea and Incident #Stroke in a National Cohort of Black and White Adults
#Sildenafil as a Candidate Drug for #Alzheimer’s Disease: Real-World Patient Data Observation and Mechanistic Observations from Patient-Induced Pluripotent Stem Cell-Derived Neurons
Abstract: Background: Alzheimer’s disease (AD) is a chronic neurodegenerative disease needing effective therapeutics urgently. Sildenafil, one of the approved phosphodiesterase-5 inhibitors, has been implicated as having potential effect in AD. Objective: To investigate the potential therapeutic benefit of sildenafil on AD. Methods: We performed real-world patient data analysis using the MarketScan® Medicare Supplemental and the Clinformatics®… Continue reading #Sildenafil as a Candidate Drug for #Alzheimer’s Disease: Real-World Patient Data Observation and Mechanistic Observations from Patient-Induced Pluripotent Stem Cell-Derived Neurons
Effectiveness of Seizure #Dogs for People With Severe Refractory #EpilepsyResults From the EPISODE Study
Background and ObjectivesThe aim of this study was to evaluate whether people living with severe medically refractory epilepsy (PSRE) benefit from a seizure dog.MethodsAn individual-level stepped-wedge randomized controlled trial was conducted. The study was conducted in the Netherlands among adults with daily to weekly seizures. All participants were included simultaneously (on June 1, 2019) while… Continue reading Effectiveness of Seizure #Dogs for People With Severe Refractory #EpilepsyResults From the EPISODE Study
Dissecting abstract, modality-specific and experience-dependent coding of affect in the human #brain
#Emotion and #perception are tightly intertwined, as affective experiences often arise from the appraisal of sensory information. Nonetheless, whether the brain encodes emotional instances using a sensory-specific code or in a more abstract manner is unclear. Here, we answer this question by measuring the association between emotion ratings collected during a unisensory or multisensory presentation… Continue reading Dissecting abstract, modality-specific and experience-dependent coding of affect in the human #brain
Effect of #gut #microbiome modulation on #muscle function and #cognition: the PROMOTe randomised controlled trial
Studies suggest that inducing gut microbiota changes may alter both muscle physiology and cognitive behaviour. Gut microbiota may play a role in both anabolic resistance of older muscle, and cognition. In this placebo controlled double blinded randomised controlled trial of 36 twin pairs (72 individuals), aged ≥60, each twin pair are block randomised to receive… Continue reading Effect of #gut #microbiome modulation on #muscle function and #cognition: the PROMOTe randomised controlled trial
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