Background and ObjectivesRacial/ethnic differences have been documented in the relationship between obstructive sleep apnea (OSA) and stroke incidence, yet racial differences in OSA symptoms or treatment and their relationship with stroke incidence are underexplored and may contribute to stroke disparities. We comprehensively examined OSA symptoms and their relationships to stroke incidence by race/ethnicity.MethodsData were collected… Continue reading Sleep #Apnea and Incident #Stroke in a National Cohort of Black and White Adults
Category: Neurology
#Sildenafil as a Candidate Drug for #Alzheimer’s Disease: Real-World Patient Data Observation and Mechanistic Observations from Patient-Induced Pluripotent Stem Cell-Derived Neurons
Abstract: Background: Alzheimer’s disease (AD) is a chronic neurodegenerative disease needing effective therapeutics urgently. Sildenafil, one of the approved phosphodiesterase-5 inhibitors, has been implicated as having potential effect in AD. Objective: To investigate the potential therapeutic benefit of sildenafil on AD. Methods: We performed real-world patient data analysis using the MarketScan® Medicare Supplemental and the Clinformatics®… Continue reading #Sildenafil as a Candidate Drug for #Alzheimer’s Disease: Real-World Patient Data Observation and Mechanistic Observations from Patient-Induced Pluripotent Stem Cell-Derived Neurons
Effectiveness of Seizure #Dogs for People With Severe Refractory #EpilepsyResults From the EPISODE Study
Background and ObjectivesThe aim of this study was to evaluate whether people living with severe medically refractory epilepsy (PSRE) benefit from a seizure dog.MethodsAn individual-level stepped-wedge randomized controlled trial was conducted. The study was conducted in the Netherlands among adults with daily to weekly seizures. All participants were included simultaneously (on June 1, 2019) while… Continue reading Effectiveness of Seizure #Dogs for People With Severe Refractory #EpilepsyResults From the EPISODE Study
Dissecting abstract, modality-specific and experience-dependent coding of affect in the human #brain
#Emotion and #perception are tightly intertwined, as affective experiences often arise from the appraisal of sensory information. Nonetheless, whether the brain encodes emotional instances using a sensory-specific code or in a more abstract manner is unclear. Here, we answer this question by measuring the association between emotion ratings collected during a unisensory or multisensory presentation… Continue reading Dissecting abstract, modality-specific and experience-dependent coding of affect in the human #brain
Effect of #gut #microbiome modulation on #muscle function and #cognition: the PROMOTe randomised controlled trial
Studies suggest that inducing gut microbiota changes may alter both muscle physiology and cognitive behaviour. Gut microbiota may play a role in both anabolic resistance of older muscle, and cognition. In this placebo controlled double blinded randomised controlled trial of 36 twin pairs (72 individuals), aged ≥60, each twin pair are block randomised to receive… Continue reading Effect of #gut #microbiome modulation on #muscle function and #cognition: the PROMOTe randomised controlled trial
Undiagnosed #Cirrhosis and Hepatic #Encephalopathy in a National Cohort of Veterans With #Dementia
Dementia and hepatic encephalopathy (HE) are challenging to distinguish clinically. Undiagnosed cirrhosis in a patient with dementia can lead to missed opportunities to treat HE.Objective To examine the prevalence and risk factors of undiagnosed cirrhosis and therefore possible HE in veterans with dementia.Design, Setting, and Participants A retrospective cohort study was conducted between 2009 and 2019 using… Continue reading Undiagnosed #Cirrhosis and Hepatic #Encephalopathy in a National Cohort of Veterans With #Dementia
The relationship between playing #musical instruments and #cognitive trajectories: Analysis from a UK ageing cohort
The accumulation of age-associated cognitive deficits can lead to Mild Cognitive Impairment (MCI) and dementia. This is a major public health issue for the modern ageing population, as it impairs health, independence and overall quality of life. Keeping the brain active during life has been associated with an increased cognitive reserve, therefore reducing the risk… Continue reading The relationship between playing #musical instruments and #cognitive trajectories: Analysis from a UK ageing cohort
Association Between Electronic Diary–Rated #Sleep, Mood, Energy, and #Stress With Incident #Headache in a Community-Based Sample
The aim of this study was to examine the diurnal links between average and changes in average levels of prospectively rated mood, sleep, energy, and stress as predictors of incident headache in a community-based sample.MethodsThis observational study included structured clinical diagnostic assessment of both headache syndromes and mental disorders and electronic diaries that were administered… Continue reading Association Between Electronic Diary–Rated #Sleep, Mood, Energy, and #Stress With Incident #Headache in a Community-Based Sample
#Statins and risks of #dementia among patients with heart failure: a population-based retrospective cohort study in Hong Kong
Heart failure (HF) and dementia frequently co-exist with shared pathological mechanisms and risk factors. Our study aims to investigate the association between statin therapy and the risks of dementia and its subtypes among patients with HF.MethodsThe Hong Kong Clinical Data Analysis and Reporting System database was interrogated to identify patients with incident HF diagnosis from… Continue reading #Statins and risks of #dementia among patients with heart failure: a population-based retrospective cohort study in Hong Kong
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