Respiratory fluoroquinolone antibiotics are some of the most common medications with QT interval–prolonging potential prescribed to patients with hemodialysis-dependent kidney failure—individuals who have a very high risk of sudden cardiac death (SCD). To date, there have been no large-scale, population-specific studies evaluating the cardiac safety of respiratory fluoroquinolones in the hemodialysis population. Objective To investigate… Continue reading Analysis of Respiratory #Fluoroquinolones and the Risk of Sudden #Cardiac Death Among Patients Receiving #Hemodialysis
Category: Nephrology
#Proteinuria as a Significant Predictive Factor for the Progression of Carotid Artery #Atherosclerosis in Non-Albuminuric Type 2 #Diabetes
The purpose of this study was to evaluate whether the urine protein to creatinine ratio (uPCR) has have clinical significance in relation to cardiovascular risk associated with carotid artery intima-media thickness (cIMT) progression, in subjects with type 2 diabetes and normoalbuminuria. MethodsIn this retrospective longitudinal study on T2D, we recruited 927 subjects with normoalbuminuria (urine… Continue reading #Proteinuria as a Significant Predictive Factor for the Progression of Carotid Artery #Atherosclerosis in Non-Albuminuric Type 2 #Diabetes
Metabolic associated fatty #liver disease is the risk factor for chronic #kidney disease
Background & AimsTo clarify the relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and chronic kidney disease (CKD). MethodsThe participants were divided into four groups by the presence or absence of fatty liver disease (FLD) and metabolic dysfunction (MD). MAFLD was defined as having both FLD and MD, whereas CKD was defined as estimated glomerular… Continue reading Metabolic associated fatty #liver disease is the risk factor for chronic #kidney disease
Second-Line Therapy for Type 2 #Diabetes Management: The Treatment/Benefit Paradox of #Cardiovascular and #Kidney Comorbidities
To examine whether glucagon-like peptide 1 receptor agonists (GLP-1RA) and sodium–glucose cotransporter 2 inhibitors (SGLT2i) are preferentially initiated among patients with cardiovascular disease, heart failure (HF), or nephropathy, where these drug classes have established benefit, compared with dipeptidyl peptidase 4 inhibitors (DPP-4i), for which corresponding benefits have not been demonstrated. RESEARCH DESIGN AND METHODS We… Continue reading Second-Line Therapy for Type 2 #Diabetes Management: The Treatment/Benefit Paradox of #Cardiovascular and #Kidney Comorbidities
Meta-Analysis of the Relationship between Abdominal #Obesity and Diabetic #Kidney Disease in Type 2 #Diabetic Patients
The meta-analysis aimed to investigate the association of visceral fat area (VFA), waist circumference (WC), waist-hip ratio (WHR) and waist-height ratio (WHtR) with diabetic kidney disease (DKD) in type 2 diabetic patients. Methods: Included studies were searched from Pubmed, Embase, and the Cochrane Library before July 2020. We synthesized the pooled results of the above… Continue reading Meta-Analysis of the Relationship between Abdominal #Obesity and Diabetic #Kidney Disease in Type 2 #Diabetic Patients
#Renal hemodynamics across the adult lifespan: Relevance of #flow pulsatility to chronic kidney disease
Elevated renal flow pulsatility may contribute to the pathogenesis of chronic kidney disease (CKD). The purpose of this study was to investigate the associations among age, renal flow pulsatility, and CKD biomarkers in non-CKD adults and CKD patients. MethodsNon-CKD adults (n = 415) and CKD patients (n = 136) aged between 22 and 83 years underwent the renal blood flow… Continue reading #Renal hemodynamics across the adult lifespan: Relevance of #flow pulsatility to chronic kidney disease
Association of #Depressive Symptoms with Rapid #Kidney Function Decline in Adults with Normal Kidney Function
The relationship of depressive symptoms with kidney function remains poorly investigated. We aimed to evaluate the prospective association between depressive symptoms and rapid decline in kidney function in Chinese adults with normal kidney function. Design, setting, participants, & measurements A total of 4763 participants with eGFR≥60 ml/min per 1.73 m2 at baseline were enrolled from… Continue reading Association of #Depressive Symptoms with Rapid #Kidney Function Decline in Adults with Normal Kidney Function
Humoral Response to the Pfizer BNT162b2 #Vaccine in Patients Undergoing Maintenance #Hemodialysis
Coronavirus disease 2019 (COVID-19) is associated with higher morbidity and mortality in patients on maintenance hemodialysis. Patients on dialysis tend to have a reduced immune response to infection or vaccination. We aimed to assess, for the first time to the best of our knowledge, the humoral response following vaccination with the BNT162b2 vaccine in patients… Continue reading Humoral Response to the Pfizer BNT162b2 #Vaccine in Patients Undergoing Maintenance #Hemodialysis
Appropriate Use of Short-Course #Antibiotics in Common #Infections: Best Practice Advice From the American College of Physicians
Antimicrobial overuse is a major health care issue that contributes to antibiotic resistance. Such overuse includes unnecessarily long durations of antibiotic therapy in patients with common bacterial infections, such as acute bronchitis with chronic obstructive pulmonary disease (COPD) exacerbation, community-acquired pneumonia (CAP), urinary tract infections (UTIs), and cellulitis. This article describes best practices for prescribing… Continue reading Appropriate Use of Short-Course #Antibiotics in Common #Infections: Best Practice Advice From the American College of Physicians
