To assess the association of height loss in old age with subsequent risk of hip and any clinical fracture in men late in life while accounting for the competing risk of mortality, we used data from 3,491 community‐dwelling men (mean age 79.2 years). Height loss between baseline and follow‐up (mean 7.0 years between examinations) was… Continue reading #Height Loss in Old Age and #Fracture Risk Among Men in Late Life: A Prospective Cohort Study
Category: Gerontology
An integrative study of five biological #clocks in somatic and mental #health
Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illness and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and determinants. In ~3000 subjects, we examined whether five biological clocks (telomere length, epigenetic, transcriptomic, proteomic, and metabolomic… Continue reading An integrative study of five biological #clocks in somatic and mental #health
Risk of Progression to #Diabetes Among Older Adults With Prediabetes
..Prediabetes defined by a glycated hemoglobin (HbA1c) level of 5.7% to 6.4%, impaired fasting glucose (IFG) level (FG level of 100-125 mg/dL), either, or both. Main Outcomes and Measures Incident total diabetes (physician diagnosis, glucose-lowering medication use, HbA1c level ≥6.5%, or FG level ≥126 mg/dL). Results A total of 3412 participants without diabetes (mean [SD]… Continue reading Risk of Progression to #Diabetes Among Older Adults With Prediabetes
#Depression and increased risk of #Alzheimer’s #dementia: longitudinal analyses of modifiable risk and sex-related factors.
Highlights •We investigated whether recent and/or remote depression was associated with increased risk of Alzheimer's Dementia (AD) and whether this risk differed between men and women. •Recent depression was independently associated with increased risk of incident AD while remote depression was not. Recent depression was predictive of AD development in females, but not in males,… Continue reading #Depression and increased risk of #Alzheimer’s #dementia: longitudinal analyses of modifiable risk and sex-related factors.
Older Adults and the Mental Health Effects of #COVID-19
As the coronavirus disease 2019 (COVID-19) began to spread in the US in early 2020, older adults experienced disproportionately greater adverse effects from the pandemic including more severe complications, higher mortality, concerns about disruptions to their daily routines and access to care, difficulty in adapting to technologies like telemedicine, and concerns that isolation would exacerbate… Continue reading Older Adults and the Mental Health Effects of #COVID-19
#Older age does not influence the success of #weight loss through the implementation of lifestyle modification
Age is sometimes a barrier for acceptance of patients into a hospital‐based obesity service. Our aim was to explore the effect of age on the ability to lose weight through lifestyle interventions, implemented within a hospital‐based obesity service.. Primary outcome measures were percentage weight loss (%WL) and percentage reduction in body mass index (%rBMI) following… Continue reading #Older age does not influence the success of #weight loss through the implementation of lifestyle modification
#Mediterranean diet, #stress resilience, and aging in nonhuman primates
Persistent psychological stress increases the risk of many chronic diseases of aging. Little progress has been made to effectively reduce stress responses or mitigate stress effects suggesting a need for better understanding of factors that influence stress responses. Limited evidence suggests that diet may be a factor in modifying the effects of stress. However, long-term… Continue reading #Mediterranean diet, #stress resilience, and aging in nonhuman primates
Elevated #LDL cholesterol and increased risk of myocardial #infarction and #atherosclerotic cardiovascular disease in individuals aged 70–100 years: a contemporary primary prevention cohort
Findings of historical studies suggest that elevated LDL cholesterol is not associated with increased risk of myocardial infarction and atherosclerotic cardiovascular disease in patients older than 70 years. We aimed to test this hypothesis in a contemporary population of individuals aged 70–100 years.. ..Between Nov 25, 2003, and Feb 17, 2015, 91 131 individuals were enrolled… Continue reading Elevated #LDL cholesterol and increased risk of myocardial #infarction and #atherosclerotic cardiovascular disease in individuals aged 70–100 years: a contemporary primary prevention cohort
Factors associated with social #isolation and being homebound among #older patients with #diabetes: a cross-sectional study
We aimed at investigating factors associated with social isolation and being homebound in older patients with diabetes.. ..Social isolation was defined as indulging in less than one interaction per week with individuals other than cohabiting family members. We defined homebound as going outside home less than once a day. To identify factors associated with social… Continue reading Factors associated with social #isolation and being homebound among #older patients with #diabetes: a cross-sectional study
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