Current and future burdens of heat-related hyponatremia – a nationwide register-based study

ContextA seasonal variation in hyponatremia, with higher incidence rates during hot summer days has been demonstrated. Whether this applies to cool temperate regions is currently unknown. ObjectiveThe aim of this study was to investigate the influence of ambient temperature on hyponatremia in the Swedish population under current and future climate scenarios. Design, setting and patientsNationwide… Continue reading Current and future burdens of heat-related hyponatremia – a nationwide register-based study

Sex-specific effects of bisphenol A on the signaling pathway of ESRRG in the human placenta

AbstractBisphenol A (BPA) exposure during pregnancy is associated with low fetal weight, particularly in male fetuses. The expression of estrogen-related receptor gamma (ESRRG), a receptor for BPA in the human placenta, is reduced in fetal growth restriction. This study sought to explore whether ESRRG signaling mediates BPA-induced placental dysfunction and determine whether changes in the… Continue reading Sex-specific effects of bisphenol A on the signaling pathway of ESRRG in the human placenta

Light exposure during sleep impairs cardiometabolic function

SignificanceAmbient nighttime light exposure is implicated as a risk factor for adverse health outcomes, including cardiometabolic disease. However, the effects of nighttime light exposure during sleep on cardiometabolic outcomes and the related mechanisms are unclear. This laboratory study shows that, in healthy adults, one night of moderate (100 lx) light exposure during sleep increases nighttime… Continue reading Light exposure during sleep impairs cardiometabolic function

Saccade-related neural communication in the human medial temporal lobe is modulated by the social relevance of stimuli

Humans predominantly explore their environment by moving their eyes. To optimally communicate and process visual information, neural activity needs to be coordinated with the execution of eye movements. We investigated the coordination between visual exploration and interareal neural communication by analyzing local field potentials and single neuron activity in patients with epilepsy. We demonstrated that… Continue reading Saccade-related neural communication in the human medial temporal lobe is modulated by the social relevance of stimuli

The Foegen effect A mechanism by which facemasks contribute to the COVID-19 case fatality rate

Extensive evidence in the literature supports the mandatory use of facemasks to reduce the infection rate of severe acute respiratory syndrome coronavirus 2, which causes the coronavirus disease (COVID-19). However, the effect of mask use on the disease course remains controversial. This study aimed to determine whether mandatory mask use influenced the case fatality rate… Continue reading The Foegen effect A mechanism by which facemasks contribute to the COVID-19 case fatality rate

Unravelling the Role of the Mandatory Use of Face Covering Masks for the Control of SARS-CoV-2 in Schools: A Quasi-Experimental Study Nested in a Population-Based Cohort in Catalonia (Spain)

Background: Mandatory use of face covering masks (FCM) had been established for children aged six and above in Catalonia (Spain), as one of the non-pharmaceutical interventions aimed at mitigating SARS-CoV-2 transmission within schools. To date, the effectiveness of this mandate has not been well established. The quasi-experimental comparison between 5 year-old children, as a control… Continue reading Unravelling the Role of the Mandatory Use of Face Covering Masks for the Control of SARS-CoV-2 in Schools: A Quasi-Experimental Study Nested in a Population-Based Cohort in Catalonia (Spain)

Association Between Screen Time Exposure in Children at 1 Year of Age and Autism Spectrum Disorder at 3 Years of AgeThe Japan Environment and Children’s Study

It is unclear to what extent the duration of screen time in infancy is associated with the subsequent diagnosis of autism spectrum disorder. Objective To examine the association between screen time in infancy and the development of autism spectrum disorder at 3 years of age. Design, Setting, and Participants This cohort study analyzed data from… Continue reading Association Between Screen Time Exposure in Children at 1 Year of Age and Autism Spectrum Disorder at 3 Years of AgeThe Japan Environment and Children’s Study

SARS-CoV-2 reinfections: Overview of efficacy and duration of natural and hybrid immunity

Highlights•A previous SARS-CoV-2 infection is associated with a significantly reduced risk of reinfections with efficacy lasting for at least one year and only relatively moderate waning immunity. •Natural immunity shows roughly similar effect sizes regarding protection against reinfection across different SARS-CoV-2 variants, with the exception of the Omicron variant for which data are just emerging… Continue reading SARS-CoV-2 reinfections: Overview of efficacy and duration of natural and hybrid immunity

The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day

Aims/hypothesisIn our modern society, artificial light is available around the clock and most people expose themselves to electrical light and light-emissive screens during the dark period of the natural light/dark cycle. Such suboptimal lighting conditions have been associated with adverse metabolic effects, and redesigning indoor lighting conditions to mimic the natural light/dark cycle more closely… Continue reading The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day