IntroductionWe investigated associations of obesity with the expression of Alzheimer's disease (AD)–related genes in a large community-based cohort.MethodsThe sample consisted of 5619 participants from the Framingham Heart Study. Obesity metrics included body mass index (BMI) and waist-to-hip ratio (WHR). Gene expression was measured for a set of 74 AD-related genes, derived by integrating genome-wide association… Continue reading Obesity impacts the expression of Alzheimer’s disease–related genes: The Framingham Heart Study
Category: Endocrinology
Effect of Verapamil on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 DiabetesA Randomized Clinical Trial
Importance In preclinical studies, thioredoxin-interacting protein overexpression induces pancreatic beta cell apoptosis and is involved in glucotoxicity-induced beta cell death. Calcium channel blockers reduce these effects and may be beneficial to beta cell preservation in type 1 diabetes.Objective To determine the effect of verapamil on pancreatic beta cell function in children and adolescents with newly… Continue reading Effect of Verapamil on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 DiabetesA Randomized Clinical Trial
Morning Exercise Reduces Abdominal Fat and Blood Pressure in Women; Evening Exercise Increases Muscular Performance in Women and Lowers Blood Pressure in Men
The ideal exercise time of day (ETOD) remains elusive regarding simultaneous effects on health and performance outcomes, especially in women.Purpose: Given known sex differences in response to exercise training, this study quantified health and performance outcomes in separate cohorts of women and men adhering to different ETOD.Methods: Thirty exercise-trained women (BMI = 24 ± 3… Continue reading Morning Exercise Reduces Abdominal Fat and Blood Pressure in Women; Evening Exercise Increases Muscular Performance in Women and Lowers Blood Pressure in Men
Pioglitazone Use and Reduced Risk of Dementia in Patients With Diabetes Mellitus With a History of Ischemic Stroke
Background and objectives: Previous studies have reported the protective effect of pioglitazone on dementia in type 2 diabetic mellitus (DM) patients. Recent studies have shown that pioglitazone also lowers the risk of primary and recurrent stroke. Understanding the characteristics of patients particularly associated with the benefits of pioglitazone would facilitate its personalized use by specifying… Continue reading Pioglitazone Use and Reduced Risk of Dementia in Patients With Diabetes Mellitus With a History of Ischemic Stroke
Phthalates and Incident Diabetes in Midlife Women: The Study of Women’s Health Across the Nation (SWAN)
ContextPhthalates are hypothesized to contribute to diabetes, but longitudinal evidence in humans is limited.ObjectiveWe examined whether phthalate exposure was associated with a higher incidence of diabetes in a racially/ethnically diverse cohort of midlife women.MethodsIn the Study of Women's Health Across the Nation Multipollutant Study, we followed 1308 women without diabetes in 1999-2000 for 6 years.… Continue reading Phthalates and Incident Diabetes in Midlife Women: The Study of Women’s Health Across the Nation (SWAN)
Vitamin D and Risk for Type 2 Diabetes in People With Prediabetes
The role of vitamin D in people who are at risk for type 2 diabetes remains unclear.Purpose:To evaluate whether administration of vitamin D decreases risk for diabetes among people with prediabetes.Data Sources:PubMed, Embase, and ClinicalTrials.gov from database inception through 9 December 2022.Study Selection:Eligible trials that were specifically designed and conducted to test the effects of… Continue reading Vitamin D and Risk for Type 2 Diabetes in People With Prediabetes
Dietary exposure to nitrites and nitrates in association with type 2 diabetes risk: Results from the NutriNet-Santé population-based cohort study
Nitrites and nitrates occur naturally in water and soil and are commonly ingested from drinking water and dietary sources. They are also used as food additives, mainly in processed meats, to increase shelf life and to avoid bacterial growth. Experimental studies suggested both benefits and harmful effects of nitrites and nitrates exposure on type 2… Continue reading Dietary exposure to nitrites and nitrates in association with type 2 diabetes risk: Results from the NutriNet-Santé population-based cohort study
Proton Pump Inhibitor Use and Risks of Cardiovascular Disease and Mortality in Patients With Type 2 Diabetes
Proton pump inhibitors (PPIs) are widely used drugs for gastric acid–related diseases and may affect the gut microbiome.ObjectiveWe aimed to evaluate the associations of PPI use with risks of cardiovascular disease (CVD) and all-cause mortality in patients with type 2 diabetes (T2D).MethodsWe analyzed the associations of PPI use with risks of coronary artery disease (CAD),… Continue reading Proton Pump Inhibitor Use and Risks of Cardiovascular Disease and Mortality in Patients With Type 2 Diabetes
Micronutrient deficiencies and anaemia associated with body mass index in Australian adults: a cross-sectional study
Aim To estimate the prevalence of micronutrient deficiencies and anaemia, and their association with body mass index (BMI) categories among Australian adults. Method We analysed data from the 2011–2013 Australian Health Survey from 3539 participants aged 18 years and over (without known pregnancy) with measured weight and height, and nutrient biomarkers. To address complex sampling,… Continue reading Micronutrient deficiencies and anaemia associated with body mass index in Australian adults: a cross-sectional study
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