Dietary habits and vascular risk factors promote both #Alzheimer’s disease and cognitive impairment caused by vascular factors. Furthermore, accumulation of hyperphosphorylated tau, a microtubule-associated protein and a hallmark of Alzheimer’s pathology, is also linked to vascular cognitive impairment. In mice, a salt-rich diet leads to cognitive dysfunction associated with a nitric oxide deficit in cerebral… Continue reading Dietary #salt promotes cognitive impairment through tau phosphorylation
Category: Diet
Potato ingestion is as effective as carbohydrate gels to support prolonged #cycling performance
We investigated the effects of potato purée ingestion during prolonged cycling on subsequent performance versus commercial CHO gel or a water-only condition. Twelve cyclists (70.7 ± 7.7 kg, 173 ± 8 cm, 31± 9 years, 22 ± 5.1 % body fat; mean ± SD) with average peak oxygen consumption (VO2PEAK)of 60.7 ± 9.0 mL/kg/min performed… Continue reading Potato ingestion is as effective as carbohydrate gels to support prolonged #cycling performance
A brief #diet intervention can reduce symptoms of #depression in young adults – A randomised controlled trial
There is strong epidemiological evidence that poor diet is associated with depression. The reverse has also been shown, namely that eating a healthy diet rich in fruit, vegetables, fish and lean meat, is associated with reduced risk of depression. Young adults with elevated levels of depression symptoms and who habitually consume a poor diet were… Continue reading A brief #diet intervention can reduce symptoms of #depression in young adults – A randomised controlled trial
Weight change across adulthood in relation to all cause and cause specific #mortality: prospective cohort study
..Compared with participants who remained at normal weight, those moving from the non-obese to obese category between young and middle adulthood had a 22% (hazard ratio 1.22, 95% confidence interval 1.11 to 1.33) and 49% (1.49, 1.21 to 1.83) higher risk of all cause mortality and heart disease mortality, respectively. Changing from obese to non-obese… Continue reading Weight change across adulthood in relation to all cause and cause specific #mortality: prospective cohort study
Impact of dietary #sucrose on #adiposity and glucose homeostasis in C57BL/6J mice depends on mode of ingestion: liquid or solid
..Since in humans consumption of sugar-sweetened beverages has been widely implicated, we investigated whether the mode of ingestion (solid or liquid) had different impacts on body weight regulation and glucose homeostasis Consumption of sucrose-sweetened water, but not equivalent levels of solid sucrose, led to body fat gain in C57BL/6 mice. Glucose intolerance was positively correlated… Continue reading Impact of dietary #sucrose on #adiposity and glucose homeostasis in C57BL/6J mice depends on mode of ingestion: liquid or solid
A brief #diet intervention can reduce symptoms of #depression in young adults – A randomised controlled trial
There is strong epidemiological evidence that poor diet is associated with depression. The reverse has also been shown, namely that eating a healthy diet rich in fruit, vegetables, fish and lean meat, is associated with reduced risk of depression No such RCTs have been performed in young adults. Young adults with elevated levels of depression… Continue reading A brief #diet intervention can reduce symptoms of #depression in young adults – A randomised controlled trial
Marine #Omega‐3 Supplementation and #Cardiovascular Disease: An Updated Meta‐Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants
In the analysis excluding REDUCE‐IT (Reduction of Cardiovascular Events with Icosapent Ethyl‐Intervention Trial), marine omega‐3 supplementation was associated with significantly lower risk of myocardial infarction (rate ratio [RR] [95% CI]: 0.92 [0.86, 0.99]; P=0.020), CHD death (RR [95% CI]: 0.92 [0.86, 0.98]; P=0.014), total CHD (RR [95% CI]: 0.95 [0.91, 0.99]; P=0.008), CVD death (RR… Continue reading Marine #Omega‐3 Supplementation and #Cardiovascular Disease: An Updated Meta‐Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants
Dietary #Sugars Alter Hepatic #Fatty Acid #Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins
Highlights • Addition of fructose to a high-fat diet increases hepatic malonyl-CoA more than glucose •Knockdown of the fructose metabolizing gene ketohexokinase increases CTP1a levels •Fructose supplementation alters mitochondrial size and function •Dietary fructose induces acetylation of ACADL and CPT1a to modify fat oxidation In summary, dietary fructose, but not glucose, supplementation of HFD impairs… Continue reading Dietary #Sugars Alter Hepatic #Fatty Acid #Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins
Population Impact Attributable to Modifiable Risk Factors for Hyperuricemia
BMI, alcohol intake, adherence to a DASH‐style diet, and diuretic use were all associated with serum urate levels and the presence of hyperuricemia in a dose‐response manner. The corresponding PARs of hyperuricemia cases for overweight/obesity (prevalence, 60%), non‐adherence to a DASH‐style diet (prevalence, 82%), alcohol use (prevalence, 48%), and diuretic use (prevalence, 8%) were 44%… Continue reading Population Impact Attributable to Modifiable Risk Factors for Hyperuricemia
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