This study aimed to investigate the association of metabolically healthy obesity (MHO) and other obesity phenotypes with electrocardiographic (#ECG) markers to understand the pathophysiological basis of increased cardiovascular disease (CVD) risk associated with these phenotypes metabolically healthy without obesity [MHNO; reference] Higher odds of prolonged PR interval, P‐wave duration, and QRS duration were observed among… Continue reading Association of #Obesity Phenotypes with Electrocardiographic Markers of Poor Outcomes in the General Population
Category: Diet
Serum elaidic acid concentration and risk of #dementia. The Hisayama study
The associations between #trans fatty acids and dementia have been unclear. We investigated the prospective association between serum elaidic acid (trans 18:1 n-9) levels, as an objective biomarker for industrial trans fat, and incident dementia and its subtypes. Higher serum elaidic acid levels were significantly associated with greater risk of developing all-cause dementia (p for… Continue reading Serum elaidic acid concentration and risk of #dementia. The Hisayama study
Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or #obese
Pre-exercise nutrient availability alters acute metabolic responses to exercise, which could modulate training responsiveness ..exercise before versus after breakfast consumption increased net intramuscular lipid utilization in type I (net change: -3.44±2.63% versus 1.44±4.18% area lipid staining, p < 0.01) and type II fibres (-1.89±2.48% versus 1.83±1.92% area lipid staining, p < 0.05). Training Study -… Continue reading Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or #obese
Comparison of #fracture risk using different supplemental doses of #vitamin D, #calcium or their combination: a network meta-analysis of randomised controlled trials
Inconsistent findings in regard to association between different concentrations of vitamin D, calcium or their combination and the risk of fracture have been reported during the past decade in community-dwelling older people A total of 25 randomised controlled trials involving 43 510 participants fulfilled the inclusion criteria. There was no evidence that the risk of… Continue reading Comparison of #fracture risk using different supplemental doses of #vitamin D, #calcium or their combination: a network meta-analysis of randomised controlled trials
Dietary #salt promotes cognitive impairment through tau phosphorylation
Dietary habits and vascular risk factors promote both #Alzheimer’s disease and cognitive impairment caused by vascular factors. Furthermore, accumulation of hyperphosphorylated tau, a microtubule-associated protein and a hallmark of Alzheimer’s pathology, is also linked to vascular cognitive impairment. In mice, a salt-rich diet leads to cognitive dysfunction associated with a nitric oxide deficit in cerebral… Continue reading Dietary #salt promotes cognitive impairment through tau phosphorylation
Potato ingestion is as effective as carbohydrate gels to support prolonged #cycling performance
We investigated the effects of potato purée ingestion during prolonged cycling on subsequent performance versus commercial CHO gel or a water-only condition. Twelve cyclists (70.7 ± 7.7 kg, 173 ± 8 cm, 31± 9 years, 22 ± 5.1 % body fat; mean ± SD) with average peak oxygen consumption (VO2PEAK)of 60.7 ± 9.0 mL/kg/min performed… Continue reading Potato ingestion is as effective as carbohydrate gels to support prolonged #cycling performance
A brief #diet intervention can reduce symptoms of #depression in young adults – A randomised controlled trial
There is strong epidemiological evidence that poor diet is associated with depression. The reverse has also been shown, namely that eating a healthy diet rich in fruit, vegetables, fish and lean meat, is associated with reduced risk of depression. Young adults with elevated levels of depression symptoms and who habitually consume a poor diet were… Continue reading A brief #diet intervention can reduce symptoms of #depression in young adults – A randomised controlled trial
Weight change across adulthood in relation to all cause and cause specific #mortality: prospective cohort study
..Compared with participants who remained at normal weight, those moving from the non-obese to obese category between young and middle adulthood had a 22% (hazard ratio 1.22, 95% confidence interval 1.11 to 1.33) and 49% (1.49, 1.21 to 1.83) higher risk of all cause mortality and heart disease mortality, respectively. Changing from obese to non-obese… Continue reading Weight change across adulthood in relation to all cause and cause specific #mortality: prospective cohort study
Impact of dietary #sucrose on #adiposity and glucose homeostasis in C57BL/6J mice depends on mode of ingestion: liquid or solid
..Since in humans consumption of sugar-sweetened beverages has been widely implicated, we investigated whether the mode of ingestion (solid or liquid) had different impacts on body weight regulation and glucose homeostasis Consumption of sucrose-sweetened water, but not equivalent levels of solid sucrose, led to body fat gain in C57BL/6 mice. Glucose intolerance was positively correlated… Continue reading Impact of dietary #sucrose on #adiposity and glucose homeostasis in C57BL/6J mice depends on mode of ingestion: liquid or solid
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