AbstractBackground & AimsSerum 25-hydroxyvitamin D (S-25(OH)D) and nonalcoholic fatty liver disease (NAFLD) are correlated in many observational studies, whereas the causality of this association is uncertain, especially in European populations. We conducted a bidirectional Mendelian randomization study to determine the association between S-25(OH)D and NAFLD. MethodsSeven and six independent genetic variants associated with S-25(OH)D and… Continue reading Inverse association between serum 25-hydroxyvitamin D and nonalcoholic fatty liver disease
Category: Diet
Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness
Studies have demonstrated a potential correlation between low vitamin D status and both an increased risk of infection with SARS-CoV-2 and poorer clinical outcomes. This retrospective study examines if, and to what degree, a relationship exists between pre-infection serum 25-hydroxyvitamin D (25(OH)D) level and disease severity and mortality due to SARS-CoV-2. ParticipantsThe records of individuals… Continue reading Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness
COVID-19 Risk Appears to Vary Across Different Alcoholic Beverages
Objectives: To evaluate the associations of status, amount, and frequency of alcohol consumption across different alcoholic beverages with coronavirus disease 2019 (COVID-19) risk and associated mortality. Methods: This study included 473,957 subjects, 16,559 of whom tested positive for COVID-19. Multivariate logistic regression analyses were used to evaluate the associations of alcohol consumption with COVID-19 risk… Continue reading COVID-19 Risk Appears to Vary Across Different Alcoholic Beverages
Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial—a randomized controlled trial
Vitamin D insufficiency is associated with risk of cardiovascular diseases (CVD) and cancer in observational studies, but evidence for benefits with vitamin D supplementation is limited. ObjectivesTo investigate the effects of vitamin D3 supplementation on CVD and cancer incidence. DesignThe study was a 5-year randomized placebo-controlled trial among 2495 male participants ≥ 60 years and… Continue reading Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial—a randomized controlled trial
Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study
BackgroundDietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China. MethodsData on 2304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included. Study randomly selected 218 out of 2304 people as subjects during… Continue reading Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: a Chinese population-based study
‘The Corpse Bride Diet’: How TikTok Inundates Teens With Eating-Disorder Videos
The app’s algorithm can send users down rabbit holes of narrow interest, resulting in potentially dangerous content such as emaciated images, purging techniques, hazardous diets and body shamingBy Tawnell D. Hobbs, Rob Barry and Yoree KohDec. 17, 2021 10:45 am ET TikTok is flooding teen users with videos of rapid-weight-loss competitions and ways to purge… Continue reading ‘The Corpse Bride Diet’: How TikTok Inundates Teens With Eating-Disorder Videos
Vitamin D deficiency is associated with higher risks for SARS-CoV-2 infection and COVID-19 severity: a retrospective case–control study
Robust evidence of whether vitamin D deficiency is associated with COVID-19 infection and its severity is still lacking. The aim of the study was to evaluate the association between vitamin D levels and the risks of SARS-CoV-2 infection and severe disease in those infected. A retrospective study was carried out among members of Clalit Health… Continue reading Vitamin D deficiency is associated with higher risks for SARS-CoV-2 infection and COVID-19 severity: a retrospective case–control study
Association between vitamin D status and risk of covid-19 in-hospital mortality: A systematic review and meta-analysis of observational studies
Some earlier studies reported higher risk of COVID-19 mortality in patients with vitamin D deficiency, while some others failed to find such as association. Due to inconsistences between earlier meta-analyses and needs for an updated study, we conducted current systematic review and meta-analysis on the association between vitamin D status and risk of COVID-19 in-hospital… Continue reading Association between vitamin D status and risk of covid-19 in-hospital mortality: A systematic review and meta-analysis of observational studies
Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk
Low vitamin D status is associated with a higher risk for cardiovascular diseases (CVDs). Although most existing linear Mendelian randomization (MR) studies reported a null effect of vitamin D on CVD risk, a non-linear effect cannot be excluded. Our aim was to apply the non-linear MR design to investigate the association of serum 25-hydroxyvitamin D… Continue reading Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk
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