Historically physicians recommend avoiding coffee in patients with arrhythmia and cardiovascular disease (CVD). However, data is lacking on safety of coffee in those with prevalent arrhythmia/CVD. We sought to investigate the associations between coffee and mortality/arrhythmia outcomes in prevalent conditionsMethods: The UK Biobank consists of 502543 people followed over > 10years. Self-reported coffee intake was divided… Continue reading 1186-021 / 21 – REGULAR COFFEE INTAKE IS ASSOCIATED WITH IMPROVED MORTALITY IN PREVALENT CARDIOVASCULAR DISEASE
Category: Diet
1052-05 – GROUND, INSTANT, OR DECAFFEINATED COFFEE? IMPACT OF DIFFERENT COFFEE SUBTYPES ON INCIDENT ARRHYTHMIA, CARDIOVASCULAR DISEASE AND MORTALITY
Background: Population studies report health benefits from coffee intake. Coffee has up to 100 biologic compounds with caffeine most well known. The effects of coffee subtypes on cardiovascular(CV) outcomes is unclear. We aim to evaluate the associations between coffee subtypes and incident arrhythmia, CV disease (CVD), and total/ CV mortalityMethods: Participant responses to coffee amount and type(ground,… Continue reading 1052-05 – GROUND, INSTANT, OR DECAFFEINATED COFFEE? IMPACT OF DIFFERENT COFFEE SUBTYPES ON INCIDENT ARRHYTHMIA, CARDIOVASCULAR DISEASE AND MORTALITY
1056-05 – EFFECTS OF HABITUAL COFFEE CONSUMPTION ON INCIDENT CARDIOVASCULAR DISEASE, ARRHYTHMIA, AND MORTALITY: FINDINGS FROM UK BIOBANK
Background: Meta analyses report beneficial effects of coffee intake on incident cardiovascular outcomes, however earlier studies are limited by smaller sample sizes. The aim was to evaluate associations between coffee intake and incident arrhythmia, CVD, and mortality, utilising the UK BiobankMethods: The UK Biobank is a large prospective cohort with outcomes measured >10 years. Coffee… Continue reading 1056-05 – EFFECTS OF HABITUAL COFFEE CONSUMPTION ON INCIDENT CARDIOVASCULAR DISEASE, ARRHYTHMIA, AND MORTALITY: FINDINGS FROM UK BIOBANK
Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease
Importance Observational studies have consistently proposed cardiovascular benefits associated with light alcohol consumption, while recent genetic analyses (ie, mendelian randomization studies) have suggested a possible causal link between alcohol intake and increased risk of cardiovascular disease. However, traditional approaches to genetic epidemiology assume a linear association and thus have not fully evaluated dose-response estimates of… Continue reading Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease
Serum folate deficiency and the risks of dementia and all-cause mortality: a national study of old age
The association between serum folate deficiency and the risk of dementia in old age is unclear, perhaps owing to small sample sizes, the competing risk of mortality or reverse causation. Objective To examine the associations between serum folate deficiency and the risks of incident dementia and all-cause mortality in a large national sample of older… Continue reading Serum folate deficiency and the risks of dementia and all-cause mortality: a national study of old age
GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage
Determinants of length of life are not well understood, and therefore increasing lifespan is a challenge. Cardinal theories of aging suggest that oxidative stress (OxS) and mitochondrial dysfunction contribute to the aging process, but it is unclear if they could also impact lifespan. Glutathione (GSH), the most abundant intracellular antioxidant, protects cells from OxS and… Continue reading GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage
Analysis of the SYSDIET Healthy Nordic Diet randomized trial based on metabolic profiling reveal beneficial effects on glucose metabolism and blood lipids
Background & aimsIntake assessment in multicenter trials is challenging, yet important for accurate outcome evaluation. The present study aimed to characterize a multicenter randomized controlled trial with a healthy Nordic diet (HND) compared to a Control diet (CD) by plasma and urine metabolic profiles and to associate them with cardiometabolic markers. MethodsDuring 18–24 weeks of… Continue reading Analysis of the SYSDIET Healthy Nordic Diet randomized trial based on metabolic profiling reveal beneficial effects on glucose metabolism and blood lipids
Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination
Multiple sclerosis (MS) is the most prevalent autoimmune disease of the central nervous system (CNS), leading to irreversible deficits in young adults. Its pathophysiology is believed to be influenced by environmental determinants. As far back as the 1990s, it had been suggested that there is a correlation between the consumption of cow’s milk and the… Continue reading Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination
Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism
The mediobasal hypothalamus (MBH) is the central region in the physiological response to metabolic stress. The FK506-binding protein 51 (FKBP51) is a major modulator of the stress response and has recently emerged as a scaffolder regulating metabolic and autophagy pathways. However, the detailed protein-protein interactions linking FKBP51 to autophagy upon metabolic challenges remain elusive. We… Continue reading Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism
2 Medical News 