Few clinical trials have evaluated diet quality change as a predictor of intervention effectiveness.ObjectivesThe aim of this study was to examine changes in the Healthy Eating Index (HEI)-2015 after a food-based intervention, and assess the associations between HEI-2015 change and intervention effects on cardiometabolic risk–related outcomes.MethodsThe Habitual Diet and Avocado Trial was a 26-wk, multicenter,… Continue reading One #Avocado per Day as Part of Usual Intake Improves #Diet Quality: Exploratory Results from a Randomized Controlled Trial
Category: Diet
Opposing diet, #microbiome, and metabolite mechanisms regulate inflammatory #bowel disease in a genetically susceptible host
Highlights•Dietary fiber-deprived gut microbiota elicits lethal colitis in Il10−/− mice•Mucolytic gut bacteria weaken mucus and drive inflammatory immune responses•Alterations in bacterial IgA coating and increased NK cells precede inflammation•Exclusive enteral nutrition promotes bacterial isobutyrate, reducing inflammationSummaryInflammatory bowel diseases (IBDs) are chronic conditions characterized by periods of spontaneous intestinal inflammation and are increasing in industrialized populations. Combined with… Continue reading Opposing diet, #microbiome, and metabolite mechanisms regulate inflammatory #bowel disease in a genetically susceptible host
Apple cider # for weight management in Lebanese adolescents and young adults with #overweight and obesity: a randomised, double-blind, placebo-controlled study
Background and aims Obesity and overweight have become significant health concerns worldwide, leading to an increased interest in finding natural remedies for weight reduction. One such remedy that has gained popularity is apple cider vinegar (ACV).Objective To investigate the effects of ACV consumption on weight, blood glucose, triglyceride and cholesterol levels in a sample of the Lebanese… Continue reading Apple cider # for weight management in Lebanese adolescents and young adults with #overweight and obesity: a randomised, double-blind, placebo-controlled study
#Diet, Pace of Biological #Aging, and Risk of #Dementia in the Framingham Heart Study
AbstractObjectivePeople who eat healthier diets are less likely to develop dementia, but the biological mechanism of this protection is not well understood. We tested the hypothesis that healthy diet protects against dementia because it slows the pace of biological aging.MethodsWe analyzed Framingham Offspring Cohort data. We included participants ≥60 years-old, free of dementia and having dietary,… Continue reading #Diet, Pace of Biological #Aging, and Risk of #Dementia in the Framingham Heart Study
Dietary #Niacin Intake and Mortality Among Individuals With Nonalcoholic #Fatty #Liver Disease
Importance Evidence regarding the effect of dietary niacin intake on the risk of mortality among patients with nonalcoholic fatty liver disease (NAFLD) is scarce.Objective To examine the association of dietary niacin intake with all-cause mortality and cardiovascular disease (CVD) mortality among individuals with NAFLD.Design, Setting, and Participants This cohort study used data from the National Health and Nutrition… Continue reading Dietary #Niacin Intake and Mortality Among Individuals With Nonalcoholic #Fatty #Liver Disease
Effect of #Ergocalciferol on β-Cell Function in New-Onset Type 1 #Diabetes A Secondary Analysis of a Randomized Clinical Trial
IntroductionApproximately 30% to 50% residual β-cell function may remain at the time of type 1 diabetes (T1D) diagnosis, and this may persist for months or years.1,2 A prolonged partial remission (PR) phase of T1D leads to improved glycemic control and decreased long-term complications.1 We previously reported1 that ergocalciferol significantly decreased circulating tumor necrosis factor (TNF)-α and temporal trends… Continue reading Effect of #Ergocalciferol on β-Cell Function in New-Onset Type 1 #Diabetes A Secondary Analysis of a Randomized Clinical Trial
Genetic investigation into the broad health implications of #caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization
BackgroundCaffeine is one of the most utilized drugs in the world, yet its clinical effects are not fully understood. Circulating caffeine levels are influenced by the interplay between consumption behaviour and metabolism. This study aimed to investigate the effects of circulating caffeine levels by considering genetically predicted variation in caffeine metabolism.MethodsLeveraging genetic variants related to… Continue reading Genetic investigation into the broad health implications of #caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization
Ultra-processed #food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses
AbstractObjective To evaluate the existing meta-analytic evidence of associations between exposure to ultra-processed foods, as defined by the Nova food classification system, and adverse health outcomes.Design Systematic umbrella review of existing meta-analyses.Data sources MEDLINE, PsycINFO, Embase, and the Cochrane Database of Systematic Reviews, as well as manual searches of reference lists from 2009 to June 2023.Eligibility criteria for… Continue reading Ultra-processed #food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses
Association of #glycaemic index and glycaemic load with type 2 #diabetes, cardiovascular disease, cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants
BackgroundThere is debate over whether the glycaemic index of foods relates to chronic disease. We aimed to assess the associations between glycaemic index (GI) and glycaemic load (GL) and type 2 diabetes, cardiovascular disease, diabetes-related cancers, and all-cause mortality.MethodsWe did a meta-analysis of large cohorts (≥100 000 participants) identified from the Richard Doll Consortium. We searched… Continue reading Association of #glycaemic index and glycaemic load with type 2 #diabetes, cardiovascular disease, cancer, and all-cause mortality: a meta-analysis of mega cohorts of more than 100 000 participants
