Non-fermented and fermented #milk intake in relation to risk of ischemic #heart disease and to circulating cardiometabolic proteins in swedish women and men: Two prospective longitudinal cohort studies with 100,775 participants

BackgroundThe effect of milk on the risk of ischemic heart disease (IHD) and acute myocardial infarction (MI) is unclear. We aimed to examine the association between non-fermented and fermented milk consumption on these endpoints and investigate the relationship between milk intake and cardiometabolic-related proteins in plasma.MethodsOur study is based on two Swedish prospective cohort studies… Continue reading Non-fermented and fermented #milk intake in relation to risk of ischemic #heart disease and to circulating cardiometabolic proteins in swedish women and men: Two prospective longitudinal cohort studies with 100,775 participants

Ultra-processed #food consumption is associated with the acceleration of biological #aging in the Moli-sani Study

BackgroundHealthy diets have been inversely associated with biological aging. However, the nutritional content is only one aspect of the overall food health potential, and more recently, increasing attention has been paid to nonnutrient food characteristics, such as food processing.ObjectivesTo examine the association of ultra-processed food (UPF) consumption with biological aging measured by circulating blood biomarkers.MethodsCross-sectional… Continue reading Ultra-processed #food consumption is associated with the acceleration of biological #aging in the Moli-sani Study

Blood #Pressure Decreases in #Overweight Elderly Individuals on Vitamin #D: A Randomized Trial

AbstractContextEvidence for a beneficial role of vitamin D on blood pressure (BP) outcomes is inconclusive.ObjectiveThis work aimed to investigate the effect of 2 doses of cholecalciferol (vitamin D3) supplementation coadministered with calcium on systolic blood pressure (SBP) and diastolic blood pressure (DBP).MethodsExploratory analyses were conducted from a 1-year, multicenter, double-blind, randomized controlled trial (RCT). Total… Continue reading Blood #Pressure Decreases in #Overweight Elderly Individuals on Vitamin #D: A Randomized Trial

Non-fermented and fermented #milk intake in relation to risk of ischemic #heart disease and to circulating cardiometabolic proteins in swedish #women and men: Two prospective longitudinal cohort studies with 100,775 participants

BackgroundThe effect of milk on the risk of ischemic heart disease (IHD) and acute myocardial infarction (MI) is unclear. We aimed to examine the association between non-fermented and fermented milk consumption on these endpoints and investigate the relationship between milk intake and cardiometabolic-related proteins in plasma.MethodsOur study is based on two Swedish prospective cohort studies… Continue reading Non-fermented and fermented #milk intake in relation to risk of ischemic #heart disease and to circulating cardiometabolic proteins in swedish #women and men: Two prospective longitudinal cohort studies with 100,775 participants

Associations of plasma omega-6 and omega-3 #fatty acids with overall and 19 site-specific #cancers: A population-based cohort study in UK Biobank

AbstractPrevious epidemiological studies on the associations between polyunsaturated fatty acids (PUFAs) and cancer incidence have been inconsistent. We investigated the associations of plasma omega-3 and omega-6 PUFAs with the incidence of overall and 19 site-specific cancers in a large prospective cohort. 253,138 eligible UK Biobank participants were included in our study. With a mean follow-up… Continue reading Associations of plasma omega-6 and omega-3 #fatty acids with overall and 19 site-specific #cancers: A population-based cohort study in UK Biobank

#Pistachio Consumption Increases #Macular Pigment #Optical Density in Healthy Adults: A Randomized Controlled Trial

BackgroundPistachios are a bioavailable source of the xanthophyll lutein. Along with zeaxanthin, these plant pigments are major components of macular pigment (MP) in the human retina. MP can be non-invasively measured and is referred to as MP optical density (MPOD). MPOD is modifiable with dietary interventions that include lutein and zeaxanthin (L/Z). Higher MPOD protects… Continue reading #Pistachio Consumption Increases #Macular Pigment #Optical Density in Healthy Adults: A Randomized Controlled Trial

#Caffeine improves systemic #lupus erythematosus endothelial dysfunction by promoting endothelial progenitor cells survival

We studied the role of caffeine intake on endothelial function in SLE by assessing its effect on circulating endothelial progenitor cells (EPCs) both ex vivo in SLE patients and in vitro in healthy donors (HD) treated with SLE sera.MethodsWe enrolled SLE patients without traditional cardiovascular risks factors. Caffeine intake was evaluated with a 7-day food… Continue reading #Caffeine improves systemic #lupus erythematosus endothelial dysfunction by promoting endothelial progenitor cells survival

Modeling sex-specific whole-body metabolic responses to #feeding and #fasting

Highlights•Sex-specific model reveals mechanisms of sexual dimorphism in glucose production.•Female model shows higher gluconeogenesis from glycerol during fasting.•TG-FFA cycle facilitates liver fat removal in females through TG secretion. AbstractMen generally favor carbohydrate metabolism, while women lean towards lipid metabolism, resulting in significant sex-based differences in energy oxidation across various metabolic states such as fasting and… Continue reading Modeling sex-specific whole-body metabolic responses to #feeding and #fasting

#Dietary restriction impacts health and #lifespan of genetically diverse mice

Caloric restriction extends healthy lifespan in multiple species1. Intermittent fasting, an alternative form of dietary restriction, is potentially more sustainable in humans, but its effectiveness remains largely unexplored2,3,4,5,6,7,8. Identifying the most efficacious forms of dietary restriction is key for developing interventions to improve human health and longevity9. Here we performed an extensive assessment of graded… Continue reading #Dietary restriction impacts health and #lifespan of genetically diverse mice