Association between #tomato consumption and #blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial

Clinical studies have produced conflicting evidence on the effects of the consumption of tomatoes on blood pressure, and there are limited data from epidemiologic studies. This study assesses whether tomato consumption (Solanum lycopersicum L.) is associated with systolic and diastolic blood pressure, and the risk of hypertension in a prospective 3-year longitudinal study in older adults… Continue reading Association between #tomato consumption and #blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial

#ATOPIC DERMATITIS PATIENT EXPERIENCE WITH DISCUSSING AND ADDRESSING MENTAL HEALTH CONCERNS WITH ALLERGISTS

Atopic dermatitis (AD) is the most common form of eczema and has a significant, multidimensional burden of disease. Patients with AD have an increased likelihood of developing depression and anxiety, which is exacerbated when additional atopic comorbidities are present. Little is known about the patient experience with discussing or addressing mental health concerns with their… Continue reading #ATOPIC DERMATITIS PATIENT EXPERIENCE WITH DISCUSSING AND ADDRESSING MENTAL HEALTH CONCERNS WITH ALLERGISTS

#Statins and cognitive decline in patients with #Alzheimer’s and mixed dementia: a longitudinal registry-based cohort study

BackgroundDisturbances in brain cholesterol homeostasis may be involved in the pathogenesis of Alzheimer’s disease (AD). Lipid-lowering medications could interfere with neurodegenerative processes in AD through cholesterol metabolism or other mechanisms.ObjectiveTo explore the association between the use of lipid-lowering medications and cognitive decline over time in a cohort of patients with AD or mixed dementia with… Continue reading #Statins and cognitive decline in patients with #Alzheimer’s and mixed dementia: a longitudinal registry-based cohort study

Short Oral Antibiotic Therapy for Pediatric Febrile #Urinary Tract Infections: A Randomized Trial

Febrile urinary tract infection (fUTI) in well-appearing children is conventionally treated with a standard 10-day course of oral antibiotic. The objective of this study is to determine the noninferiority (5% threshold) of a 5-day amoxicillin-clavulanate course compared with a 10-day regimen to treat fUTIs.METHODSThis is a multicenter, investigator-initiated, parallel-group, randomized, controlled trial. We randomly assigned… Continue reading Short Oral Antibiotic Therapy for Pediatric Febrile #Urinary Tract Infections: A Randomized Trial

Effects of calibrated blue–yellow changes in light on the human #circadian clock

Evening exposure to short-wavelength light can affect the circadian clock, sleep and alertness. Intrinsically photosensitive retinal ganglion cells expressing melanopsin are thought to be the primary drivers of these effects. Whether colour-sensitive cones also contribute is unclear. Here, using calibrated silent-substitution changes in light colour along the blue–yellow axis, we investigated whether mechanisms of colour… Continue reading Effects of calibrated blue–yellow changes in light on the human #circadian clock

Changes in #Hospital Adverse Events and Patient Outcomes Associated With #Private Equity Acquisition

The effects of private equity acquisitions of US hospitals on the clinical quality of inpatient care and patient outcomes remain largely unknown.Objective  To examine changes in hospital-acquired adverse events and hospitalization outcomes associated with private equity acquisitions of US hospitals.Design, Setting, and Participants  Data from 100% Medicare Part A claims for 662 095 hospitalizations at 51 private equity–acquired… Continue reading Changes in #Hospital Adverse Events and Patient Outcomes Associated With #Private Equity Acquisition

Multi-site #microbiota alteration is a hallmark of kidney #stone formation

Inquiry of microbiota involvement in kidney stone disease (KSD) has largely focussed on potential oxalate handling abilities by gut bacteria and the increased association with antibiotic exposure. By systematically comparing the gut, urinary, and oral microbiota of 83 stone formers (SF) and 30 healthy controls (HC), we provide a unified assessment of the bacterial contribution… Continue reading Multi-site #microbiota alteration is a hallmark of kidney #stone formation

Abstract 13719: Minimal and Delayed Age-Related Increase of Arterial #Stiffness Among Tsimane Forager-Horticulturalists

Background: Tsimane forager-farmers of the Bolivian Amazon exhibit a distinct trajectory of vascular aging, characterized by low age-related increases in BP, the lowest levels of coronary calcification ever reported, and robust VO2 max. However, the prevalence of arterial stiffness (ArSt) in this population and its association with age and other cardiovascular risk factors are unknown.Methods: Large artery elasticity… Continue reading Abstract 13719: Minimal and Delayed Age-Related Increase of Arterial #Stiffness Among Tsimane Forager-Horticulturalists