INTRODUCTIONOur population-based study assessed whether clinically apparent Helicobacter pylori infection (CAHPI) is associated with the risk of Alzheimer's disease (AD).METHODSWe assembled a population-based cohort of all dementia-free subjects in the United Kingdom's Clinical Practice Research Datalink (UK CPRD), aged ≥50 years (1988–2017). Using a nested case-control approach, we matched each newly developed case of AD with 40… Continue reading Clinically apparent #Helicobacter pylori infection and the risk of incident #Alzheimer’s disease: A population-based nested case-control study
Author: aledopress
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Enhanced SREBP2-driven #cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis
The metabolic and signaling pathways regulating aggressive mesenchymal colorectal cancer (CRC) initiation and progression through the serrated route are largely unknown. Although relatively well characterized as BRAF mutant cancers, their poor response to current targeted therapy, difficult preneoplastic detection, and challenging endoscopic resection make the identification of their metabolic requirements a priority. Here, we demonstrate… Continue reading Enhanced SREBP2-driven #cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis
#Walking speed and the risk of type 2 #diabetes: a systematic review and meta-analysis
Objective To investigate the association between walking speed and the risk of type 2 diabetes.Design Systematic review and meta-analysis.Data sources PubMed, Scopus, CENTRAL and Web of Science to 30 May 2023.Eligibility criteria for selecting studies We included cohort studies that explored the association between walking speed and the risk of type 2 diabetes in adults. We used random-effects meta-analyses… Continue reading #Walking speed and the risk of type 2 #diabetes: a systematic review and meta-analysis
Neurophysiological and behavioral synchronization in group-living and #sleeping mice
Social interactions profoundly influence animal development, physiology, and behavior. Yet, how sleep—a central behavioral and neurophysiological process—is modulated by social interactions is poorly understood. Here, we characterized sleep behavior and neurophysiology in freely moving and co-living mice under different social conditions. We utilized wireless neurophysiological devices to simultaneously record multiple individuals within a group for 24 h, alongside video acquisition. We… Continue reading Neurophysiological and behavioral synchronization in group-living and #sleeping mice
Cortical reactivations predict future sensory responses
Many theories of offline memory consolidation posit that the pattern of neurons activated during a salient sensory experience will be faithfully reactivated, thereby stabilizing the pattern1,2. However, sensory-evoked patterns are not stable but, instead, drift across repeated experiences3,4,5,6. Here, to investigate the relationship between reactivations and the drift of sensory representations, we imaged the calcium… Continue reading Cortical reactivations predict future sensory responses
Dietary #circadian rhythms and #cardiovascular disease risk in the prospective NutriNet-Santé cohort
Dietary circadian rhythms and #cardiovascular disease risk in the prospective NutriNet-Santé cohortDaily eating/fasting cycles synchronise circadian peripheral clocks, involved in the regulation of the cardiovascular system. However, the associations of daily meal and fasting timing with cardiovascular disease (CVD) incidence remain unclear. We used data from 103,389 adults in the NutriNet-Santé study. Meal timing and… Continue reading Dietary #circadian rhythms and #cardiovascular disease risk in the prospective NutriNet-Santé cohort
Woodcuts as Reading Guides: How Images Shaped Knowledge Transmission in Medical-Astrological Books in Dutch (1500-1550) by Andrea van Leerdam (2023)
Woodcuts as Reading Guides: How Images Shaped Knowledge Transmission in Medical-Astrological Books in Dutch (1500-1550) by Andrea van Leerdam (2023) In the first half of the sixteenth century, the Low Countries saw the rise of a lively market for practical and instructive books that targeted non-specialist readers. This study shows how woodcuts in vernacular books… Continue reading Woodcuts as Reading Guides: How Images Shaped Knowledge Transmission in Medical-Astrological Books in Dutch (1500-1550) by Andrea van Leerdam (2023)
#Statin Use and the Risk of Venous #Thromboembolism in Women Taking #Hormone Therapy
Although hormone therapy (HT) in perimenopausal women is associated with increased risk for venous thromboembolism (VTE), it is unclear to what extent statins may mitigate this HT-associated risk.Objective To estimate VTE risk in women aged 50 to 64 years taking HT with or without statins.Design, Setting, and Participants This nested case-control study analyzed data from a commercially… Continue reading #Statin Use and the Risk of Venous #Thromboembolism in Women Taking #Hormone Therapy
NR-SAFE: a randomized, double-blind safety trial of high dose #nicotinamide riboside in #Parkinson’s disease
Nicotinamide adenine dinucleotide (NAD) replenishment therapy using nicotinamide riboside (NR) shows promise for Parkinson’s disease (PD) and other neurodegenerative disorders. However, the optimal dose of NR remains unknown, and doses exceeding 2000 mg daily have not been tested in humans. To evaluate the safety of high-dose NR therapy, we conducted a single-center, randomized, placebo-controlled, double-blind,… Continue reading NR-SAFE: a randomized, double-blind safety trial of high dose #nicotinamide riboside in #Parkinson’s disease
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