Multi-omic profiling in FHS reveals microbes and metabolites associated with CVD•Oscillibacter species are associated with decreased blood and stool cholesterol•Homology searches and molecular networking predict cholesterol enzymes and products•Oscillibacter species encode for conserved cholesterol-metabolizing enzymesSummaryAccumulating evidence suggests that cardiovascular disease (CVD) is associated with an altered gut microbiome. Our understanding of the underlying mechanisms has been hindered… Continue reading Gut #microbiome and metabolome profiling in Framingham heart study reveals #cholesterol-metabolizing bacteria
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Early Use of #Erenumab vs Nonspecific Oral #Migraine PreventivesThe APPRAISE Randomized Clinical Trial
Importance Patients with migraine often cycle through multiple nonspecific preventive medications due to poor tolerability and/or inadequate efficacy leading to low adherence and increased disease burden.Objective To compare the efficacy, tolerability, patient adherence, and patient satisfaction between erenumab and nonspecific oral migraine preventive medications (OMPMs) in patients with episodic migraine (EM) who had previously failed 1 or… Continue reading Early Use of #Erenumab vs Nonspecific Oral #Migraine PreventivesThe APPRAISE Randomized Clinical Trial
#Sarcopenia and Sarcopenic #Obesity and Mortality Among Older People
Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of the combination of sarcopenia with obesity (sarcopenic obesity [SO]) and its association with mortality are still limited.Objective To investigate the prevalence of sarcopenia and SO and their association with all-cause mortality.Design, Setting, and Participants This large-scale,… Continue reading #Sarcopenia and Sarcopenic #Obesity and Mortality Among Older People
One #Avocado per Day as Part of Usual Intake Improves #Diet Quality: Exploratory Results from a Randomized Controlled Trial
Few clinical trials have evaluated diet quality change as a predictor of intervention effectiveness.ObjectivesThe aim of this study was to examine changes in the Healthy Eating Index (HEI)-2015 after a food-based intervention, and assess the associations between HEI-2015 change and intervention effects on cardiometabolic risk–related outcomes.MethodsThe Habitual Diet and Avocado Trial was a 26-wk, multicenter,… Continue reading One #Avocado per Day as Part of Usual Intake Improves #Diet Quality: Exploratory Results from a Randomized Controlled Trial
Longitudinal Associations Between #Optimism and Objective Measures of #Physical Functioning in Women
Identifying factors contributing to sustained physical functioning is critical for the health and well-being of the aging population, especially as physical functioning may precede and predict subsequent health outcomes. Prior work suggests optimism may protect health, but less is known about the association between optimism and objective physical functioning measures as individuals age.Objective To evaluate the… Continue reading Longitudinal Associations Between #Optimism and Objective Measures of #Physical Functioning in Women
Opposing diet, #microbiome, and metabolite mechanisms regulate inflammatory #bowel disease in a genetically susceptible host
Highlights•Dietary fiber-deprived gut microbiota elicits lethal colitis in Il10−/− mice•Mucolytic gut bacteria weaken mucus and drive inflammatory immune responses•Alterations in bacterial IgA coating and increased NK cells precede inflammation•Exclusive enteral nutrition promotes bacterial isobutyrate, reducing inflammationSummaryInflammatory bowel diseases (IBDs) are chronic conditions characterized by periods of spontaneous intestinal inflammation and are increasing in industrialized populations. Combined with… Continue reading Opposing diet, #microbiome, and metabolite mechanisms regulate inflammatory #bowel disease in a genetically susceptible host
Statin Use and All-Cause Mortality in Nursing Home Residents With and Without DementiaA Retrospective Cohort Study Using Claims Data
Little is known about the benefits of statin therapy in older adults with dementia. We aimed to evaluate the role of statin use for all-cause mortality in nursing home residents with and without dementia.MethodsThis retrospective cohort study used claims data collected between January 2015 and December 2019 from a German health and long-term care insurance… Continue reading Statin Use and All-Cause Mortality in Nursing Home Residents With and Without DementiaA Retrospective Cohort Study Using Claims Data
Summary: A new study explores the molecular connections between Type 2 #diabetes and #Alzheimer’s, supporting the notion of Alzheimer’s as “Type 3 diabetes.”
This study finds that a high-fat diet suppresses a crucial gut protein, Jak3, leading to Alzheimer’s-like brain changes in mice. It underscores the importance of managing diabetes or avoiding it through diet to reduce Alzheimer’s risk.The findings illuminate a potential path from diet through gut inflammation to brain health, offering hope for preventative strategies.Key Facts:Molecular… Continue reading Summary: A new study explores the molecular connections between Type 2 #diabetes and #Alzheimer’s, supporting the notion of Alzheimer’s as “Type 3 diabetes.”
Apple cider # for weight management in Lebanese adolescents and young adults with #overweight and obesity: a randomised, double-blind, placebo-controlled study
Background and aims Obesity and overweight have become significant health concerns worldwide, leading to an increased interest in finding natural remedies for weight reduction. One such remedy that has gained popularity is apple cider vinegar (ACV).Objective To investigate the effects of ACV consumption on weight, blood glucose, triglyceride and cholesterol levels in a sample of the Lebanese… Continue reading Apple cider # for weight management in Lebanese adolescents and young adults with #overweight and obesity: a randomised, double-blind, placebo-controlled study
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