BACKGROUNDMost trials that have shown a benefit of beta-blocker treatment after myocardial infarction included patients with large myocardial infarctions and were conducted in an era before modern biomarker-based diagnosis of myocardial infarction and treatment with percutaneous coronary intervention, antithrombotic agents, high-intensity statins, and renin–angiotensin–aldosterone system antagonists.METHODSIn a parallel-group, open-label trial performed at 45 centers in… Continue reading #Beta-Blockers after Myocardial #Infarction and Preserved #Ejection Fraction
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Safety and efficacy of faecal #microbiota transplantation in patients with mild to moderate #Parkinson’s disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial
Dysregulation of the gut microbiome has been implicated in Parkinson's disease (PD). This study aimed to evaluate the clinical effects and safety of a single faecal microbiota transplantation (FMT) in patients with early-stage PD.MethodsThe GUT-PARFECT trial, a single-centre randomised, double-blind, placebo-controlled trial was conducted at Ghent University Hospital between December 01, 2020 and December 12,… Continue reading Safety and efficacy of faecal #microbiota transplantation in patients with mild to moderate #Parkinson’s disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial
Prevalence of dementia among people experiencing homelessness in Ontario, Canada: a population-based comparative analysis
Cognitive decline in people experiencing homelessness is an increasingly recognised issue. We compared the prevalence of dementia among people experiencing homelessness to housed individuals in the general population and those living in low-income neighbourhoods.MethodsWe conducted a population-based, cross-sectional, comparative analysis using linked health-care administrative data from Ontario, Canada. We included individuals aged 45 years or… Continue reading Prevalence of dementia among people experiencing homelessness in Ontario, Canada: a population-based comparative analysis
Associations of #dietary patterns with #brain health from behavioral, neuroimaging, biochemical and genetic analyses
Food preferences significantly influence dietary choices, yet understanding natural dietary patterns in populations remains limited. Here we identifiy four dietary subtypes by applying data-driven approaches to food-liking data from 181,990 UK Biobank participants: ‘starch-free or reduced-starch’ (subtype 1), ‘vegetarian’ (subtype 2), ‘high protein and low fiber’ (subtype 3) and ‘balanced’ (subtype 4). These subtypes varied… Continue reading Associations of #dietary patterns with #brain health from behavioral, neuroimaging, biochemical and genetic analyses
#Virtual reality for #pain management in hospitalized patients with #cancer: A randomized controlled trial
Hospitalized patients with cancer often experience acute and/or chronic pain. Although virtual reality (VR) has been extensively studied across a wide range of clinical settings, no studies have yet evaluated potential impact on pain management in this patient population.MethodsProspective randomized controlled trial at an urban academic hospital comparing VR against an active control to mitigate… Continue reading #Virtual reality for #pain management in hospitalized patients with #cancer: A randomized controlled trial
Impact of #Mental Health Treatment on Outcomes in Patients With #Heart Failure and Ischemic Heart Disease
BackgroundThere is conflicting evidence as to the impact of mental health treatment on outcomes in patients with heart disease. The aim of this study was to examine whether individuals who received mental health treatment for anxiety or depression after being hospitalized for ischemic disorders or heart failure had a reduced frequency of rehospitalizations, emergency department… Continue reading Impact of #Mental Health Treatment on Outcomes in Patients With #Heart Failure and Ischemic Heart Disease
Morphological and genetic decoding shows heterogeneous patterns of brain aging in chronic #musculosckeletal pain
Chronic musculoskeletal pain (CMP), a prevalent and heterogeneous condition characterized by persistent pain in various body parts, is a leading cause of disability worldwide and greatly affects a patient’s brain. Apart from experiencing pain, older adults with CMP also have accelerated cognitive decline and higher dementia risk with limited understanding of biological mechanism underlying the… Continue reading Morphological and genetic decoding shows heterogeneous patterns of brain aging in chronic #musculosckeletal pain
Scanning #ultrasound-mediated memory and functional improvements do not require #amyloid-β reduction
A prevalent view in treating age-dependent disorders including Alzheimer’s disease (AD) is that the underlying amyloid plaque pathology must be targeted for cognitive improvements. In contrast, we report here that repeated scanning ultrasound (SUS) treatment at 1 MHz frequency can ameliorate memory deficits in the APP23 mouse model of AD without reducing amyloid-β (Aβ) burden. Different… Continue reading Scanning #ultrasound-mediated memory and functional improvements do not require #amyloid-β reduction
Risk Factors and Incidence of #Gastric #Cancer After Detection of #Helicobacter pylori Infection: A Large Cohort Study
Risk Factors and Incidence of Gastric Cancer After Detection of Helicobacter pylori Infection: A Large Cohort StudyShria KumarDavid C. MetzSusan EllenbergDavid E. KaplanDavid S. Goldberg Published:October 22, 2019DOI:https://doi.org/10.1053/j.gastro.2019.10.019PlumX MetricsBackground & AimsNearly all studies of gastric adenocarcinoma in the United States have relied on national cancer databases, which do not include data on Helicobacter pylori infection, the most well-known risk factor… Continue reading Risk Factors and Incidence of #Gastric #Cancer After Detection of #Helicobacter pylori Infection: A Large Cohort Study
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