Because of the extensive use of this drug, further evaluation of acute liver injury (ALI) with therapeutic doses of acetaminophen (APAP; ≤6 g/d) is required. We characterize ALI with therapeutic doses of APAP and determine the host factors associated with disease severity and the predictors of outcome. Approach and Results All patients admitted with severe… Continue reading Acute #Liver Injury With Therapeutic Doses of #Acetaminophen: A Prospective Study
Author: aledopress
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Associations between adolescent #cannabis use and young-adult functioning in three longitudinal twin studies
Observational studies have linked cannabis use to an array of negative outcomes, including psychiatric symptoms, cognitive impairment, and educational and occupational underachievement. These associations are particularly strong when cannabis use occurs in adolescence. Nevertheless, causality remains unclear. The purpose of the present study was thus to examine associations between prospectively assessed adolescent cannabis use and… Continue reading Associations between adolescent #cannabis use and young-adult functioning in three longitudinal twin studies
Online #Mindfulness May Target Psychological #Distress and Mental Health during #COVID-19
The COVID-19 pandemic has dramatically affected mental health, creating an urgent need for convenient and safe interventions to improve well-being. Online mindfulness interventions show promise for improving depression, anxiety, and general well-being. Objective To assess: 1) the impact of online mindfulness on psychological distress, 2) altruistic efforts, and 3) the quantity, quality, and availability of… Continue reading Online #Mindfulness May Target Psychological #Distress and Mental Health during #COVID-19
#Meat consumption and risk of incident #dementia: cohort study of 493,888 UK Biobank participants
Worldwide, the prevalence of dementia is increasing and diet as a modifiable factor could play a role. Meat consumption has been cross-sectionally associated with dementia risk, but specific amounts and types related to risk of incident dementia remain poorly understood. Objective We aimed to investigate associations between meat consumption and risk of incident dementia in… Continue reading #Meat consumption and risk of incident #dementia: cohort study of 493,888 UK Biobank participants
Effectiveness and Safety of Direct Oral #Anticoagulants Versus Warfarin in Patients With Valvular Atrial #Fibrillation
Direct oral anticoagulants (DOACs) are increasingly used in place of warfarin, but evidence about their effectiveness and safety in patients with valvular atrial fibrillation (AF) remains limited. Objective: To assess the effectiveness and safety of DOACs compared with warfarin in patients with valvular AF. Design: New-user retrospective propensity score–matched cohort study. Setting: U.S.-based commercial health… Continue reading Effectiveness and Safety of Direct Oral #Anticoagulants Versus Warfarin in Patients With Valvular Atrial #Fibrillation
#Caffeine increases maximal #fat oxidation during a graded exercise test: is there a diurnal variation?
There is evidence that caffeine increases the maximal fat oxidation rate (MFO) and aerobic capacity, which are known to be lower in the morning than in the afternoon. This paper examines the effect of caffeine intake on the diurnal variation of MFO during a graded exercise test in active men. Methods Using a triple-blind, placebo-controlled,… Continue reading #Caffeine increases maximal #fat oxidation during a graded exercise test: is there a diurnal variation?
The mixed benefits of a #stressor-free life.
Research documents the pernicious effects of daily stressors on well-being, but often ignored in these studies are people reporting no stressors. The current study compared adults who reported no daily stressors with adults who reported at least one stressor across 8 consecutive days on measures of well-being. Of the 2,804 respondents (age range = 25–75… Continue reading The mixed benefits of a #stressor-free life.
Sex- and age-specific genetic analysis of chronic back #pain
Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity, and poorer response to treatment. Genetic factors acting in an age-specific manner have been implicated but never comprehensively explored. We performed sex- and age-stratified genome-wide association study and single nucleotide polymorphism-by-sex interaction analysis for cBP defined as “Back… Continue reading Sex- and age-specific genetic analysis of chronic back #pain
Association Between Maternal #Caffeine Consumption and Metabolism and Neonatal Anthropometry
Higher caffeine consumption during pregnancy has been associated with lower birth weight. However, associations of caffeine consumption, based on both plasma concentrations of caffeine and its metabolites, and self-reported caffeinated beverage intake, with multiple measures of neonatal anthropometry, have yet to be examined. Objective To evaluate the association between maternal caffeine intake and neonatal anthropometry,… Continue reading Association Between Maternal #Caffeine Consumption and Metabolism and Neonatal Anthropometry
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