Piezo1 forms mechanically activated nonselective cation channels that contribute to endothelial response to fluid flow. Here we reveal an important role in the control of capillary density. Conditional endothelial cell–specific deletion of Piezo1 in adult mice depressed physical performance. Muscle microvascular endothelial cell apoptosis and capillary rarefaction were evident and sufficient to account for the… Continue reading Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity
Author: aledopress
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The effects of music & auditory beat stimulation on anxiety: A randomized clinical trial
Background and objectivesMusic and auditory beat stimulation (ABS) in the theta frequency range (4–7 Hz) are sound-based anxiety treatments that have been independently investigated in prior studies. Here, the anxiety-reducing potential of calm music combined with theta ABS was examined in a large sample of participants. MethodsAn open-label randomized controlled trial was conducted with participants… Continue reading The effects of music & auditory beat stimulation on anxiety: A randomized clinical trial
Oral Microbiome Is Associated With Incident Hypertension Among Postmenopausal Women
BackgroundOral microbiota are thought to influence blood pressure (BP) regulation. However, epidemiological data supporting this hypothesis are limited. We examined associations between oral microbiota, BP, and incident hypertension in postmenopausal women. Methods and ResultsBaseline (1997–2001) examinations were completed on 1215 women (mean age, 63 years) during which subgingival plaque was collected, BP was measured, and… Continue reading Oral Microbiome Is Associated With Incident Hypertension Among Postmenopausal Women
Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant
BACKGROUNDA rapid increase in coronavirus disease 2019 (Covid-19) cases due to the omicron (B.1.1.529) variant of severe acute respiratory syndrome coronavirus 2 in highly vaccinated populations has aroused concerns about the effectiveness of current vaccines. METHODSWe used a test-negative case–control design to estimate vaccine effectiveness against symptomatic disease caused by the omicron and delta (B.1.617.2)… Continue reading Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant
Prospective associations between alcohol consumption and psychological well-being in midlife
BackgroundAlcohol consumption potentially influences psychological well-being in beneficial and harmful ways, but prospective studies on the association show mixed results. Our main purpose was to examine prospective associations between alcohol consumption and psychological well-being in middle-aged men and women. MethodsThe study sample included 4148 middle-aged individuals (80% men) from the Copenhagen Aging and Midlife Biobank… Continue reading Prospective associations between alcohol consumption and psychological well-being in midlife
VTE Prophylaxis in Critically Ill AdultsA Systematic Review and Network Meta-analysis
BackgroundCritically ill adults are at increased risk of VTE, including DVT, and pulmonary embolism. Various agents exist for venous thromboprophylaxis in this population. Research QuestionWhat is the comparative efficacy and safety of prophylaxis agents for prevention of VTE in critically ill adults?Study Design and MethodsSystematic review and network meta-analysis of randomized clinical trials (RCTs) evaluating… Continue reading VTE Prophylaxis in Critically Ill AdultsA Systematic Review and Network Meta-analysis
Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population
Importance Early features of Parkinson disease (PD) have been described through population-based studies that overrepresent White, affluent groups and may not be generalizable. Objective To investigate the association between risk factors and prediagnostic presentations of PD in an ethnically diverse UK population with high socioeconomic deprivation but universal access to health care. Design, Setting, and… Continue reading Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population
Prospective Analyses of Sedentary Behavior in Relation to Risk of Ovarian Cancer
To examine the association of sedentary behavior with risk of ovarian cancer overall, by tumor subtype, and by participant characteristics in the Nurses’ Health Study (NHS) and NHSII. A total of 69,558 NHS (1992-2016) and 104,130 NHSII (1991-2015) participants were included in analysis who reported sitting time at home, work, and watching television, which included… Continue reading Prospective Analyses of Sedentary Behavior in Relation to Risk of Ovarian Cancer
Associations between alcohol consumption and gray and white matter volumes in the UK Biobank
Heavy alcohol consumption has been associated with brain atrophy, neuronal loss, and poorer white matter fiber integrity. However, there is conflicting evidence on whether light-to-moderate alcohol consumption shows similar negative associations with brain structure. To address this, we examine the associations between alcohol intake and brain structure using multimodal imaging data from 36,678 generally healthy… Continue reading Associations between alcohol consumption and gray and white matter volumes in the UK Biobank
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