Author: aledopress

Medicine and Technology enthusiast..

Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity

aledopress

Breast milk IgG adds valueAlthough the most abundant class of antibody present in breast milk is IgA, maternal IgG antibodies also get transferred into breast milk via the neonatal Fc receptor. Sanidad et al. used mouse models to investigate the capacity of breast milk IgG to protect against pathogens and promote the establishment of a… Continue reading Maternal gut microbiome–induced IgG regulates neonatal gut microbiome and immunity

Researcher: ‘We Made a Big Mistake’ on COVID-19 Vaccine

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Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., has gained access to Pfizer’s biodistribution study from the Japanese regulatory agency. The research demonstrates a huge problem with all COVID-19 vaccines The assumption that vaccine developers have been working with is that the mRNA in the vaccines would primarily remain in and around the vaccination site.… Continue reading Researcher: ‘We Made a Big Mistake’ on COVID-19 Vaccine

Aspirin’s effect on kinetic parameters ofcells contributes to its role in reducingincidence of advanced colorectaladenomas, shown by a multiscalecomputational study

aledopress

Aspirin intake has been shown to lead to significant protection against colorectalcancer, for example with an up to twofold reduction in colorectal adenoma incidence rates at higherdoses. The mechanisms contributing to protection are not yet fully understood. While aspirin isan anti-inflammatory drug and can thus influence the tumor microenvironment, in vitro and in vivoexperiments have… Continue reading Aspirin’s effect on kinetic parameters ofcells contributes to its role in reducingincidence of advanced colorectaladenomas, shown by a multiscalecomputational study

Gender Dysphoria and Suicidal Ideation: Clinical Observations from a Psychiatric Emergency Service

aledopress

Adolescent gender dysphoria is increasingly common. There has been documentation of the association of gender dysphoria with numerous other psychiatric conditions as well as attempted and completed suicide. The literature is unsettled on specific risk factors for self-harm within this population. Though there are published recommendations, there appears to be a need for additional clinical… Continue reading Gender Dysphoria and Suicidal Ideation: Clinical Observations from a Psychiatric Emergency Service

Had COVID? You’ll probably make antibodies for a lifetime

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People who recover from mild COVID-19 have bone-marrow cells that can churn out antibodies for decades, although viral variants could dampen some of the protection they offer. Many people who have been infected with SARS-CoV-2 will probably make antibodies against the virus for most of their lives. So suggest researchers who have identified long-lived antibody-producing… Continue reading Had COVID? You’ll probably make antibodies for a lifetime

Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death

aledopress

The intestinal microbiome releases a plethora of small molecules. Here, we show that the Ruminococcaceae metabolite isoamylamine (IAA) is enriched in aged mice and elderly people, whereas Ruminococcaceae phages, belonging to the Myoviridae family, are reduced. Young mice orally administered IAA show cognitive decline, whereas Myoviridae phage administration reduces IAA levels. Mechanistically, IAA promotes apoptosis… Continue reading Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death

Burnout in emergency medicine professionals after 2 years of the COVID-19 pandemic: a threat to the healthcare system?

aledopress

AbstractBackground: Burnout is a common problem among healthcare professionals (HCPs), in particular young doctors and nurses working in emergency medical services. The coronavirus disease 2019 (COVID-19) pandemic has generated a substantial increase in the workload of those working in front-line services, and there is evidence of physical and mental distress among professionals that may have… Continue reading Burnout in emergency medicine professionals after 2 years of the COVID-19 pandemic: a threat to the healthcare system?

Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals with Anorexia Nervosa – A Coordinated Analysis by the ENIGMA Eating Disorders Working Group

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BackgroundThe pattern of structural brain abnormalities in anorexia nervosa (AN) is still not well understood. While several studies report substantial deficits in grey matter volume and cortical thickness in acutely underweight patients, others find no differences, or even increases in patients compared with healthy controls. Recent weight regain before scanning may explain some of this… Continue reading Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals with Anorexia Nervosa – A Coordinated Analysis by the ENIGMA Eating Disorders Working Group