Children born to parents who are overweight or obese have a high risk of adult obesity, but it is unclear if transgenerational associations relating to unfavorable body composition differ by parent.ObjectiveTo examine differential mother-offspring and father-offspring associations in body composition in early childhood.MethodsA total of 240 mother-father-offspring trios from a prospective UK population-based pre-birth cohort… Continue reading Parent-Offspring Associations in Body Composition: Findings From the Southampton Women’s Survey Prospective Cohort Study
Tag: Obesity
Obesity impacts the expression of Alzheimer’s disease–related genes: The Framingham Heart Study
IntroductionWe investigated associations of obesity with the expression of Alzheimer's disease (AD)–related genes in a large community-based cohort.MethodsThe sample consisted of 5619 participants from the Framingham Heart Study. Obesity metrics included body mass index (BMI) and waist-to-hip ratio (WHR). Gene expression was measured for a set of 74 AD-related genes, derived by integrating genome-wide association… Continue reading Obesity impacts the expression of Alzheimer’s disease–related genes: The Framingham Heart Study
Micronutrient deficiencies and anaemia associated with body mass index in Australian adults: a cross-sectional study
Aim To estimate the prevalence of micronutrient deficiencies and anaemia, and their association with body mass index (BMI) categories among Australian adults. Method We analysed data from the 2011–2013 Australian Health Survey from 3539 participants aged 18 years and over (without known pregnancy) with measured weight and height, and nutrient biomarkers. To address complex sampling,… Continue reading Micronutrient deficiencies and anaemia associated with body mass index in Australian adults: a cross-sectional study
Weight loss strategies, weight change, and type 2 diabetes in US health professionals: A cohort study
BackgroundWeight loss is crucial for disease prevention among individuals with overweight or obesity. This study aimed to examine associations of weight loss strategies (WLSs) with weight change and type 2 diabetes (T2D) risk among US health professionals.Methods and findingsThis study included 93,110 participants (24 to 60 years old; 11.6% male) from the Nurses’ Health Study… Continue reading Weight loss strategies, weight change, and type 2 diabetes in US health professionals: A cohort study
Diabetes and Obesity in Down Syndrome Across the Lifespan: A Retrospective Cohort Study Using U.K. Electronic Health Records
Down syndrome (DS) is the most common form of chromosomal trisomy. Genetic factors in DS may increase the risk for diabetes. This study aimed to determine whether DS is associated with an increased incidence of diabetes and the relationship with obesity across the life span compared with control patients.RESEARCH DESIGN AND METHODSThis matched population–based cohort… Continue reading Diabetes and Obesity in Down Syndrome Across the Lifespan: A Retrospective Cohort Study Using U.K. Electronic Health Records
Light at night in older age is associated with obesity, diabetes, and hypertension
Light at night (LAN) has been associated with negative health consequences and metabolic risk factors. Little is known about the prevalence of LAN in older adults in the U.S. and its association with cardiovascular disease (CVD) risk factors. We tested the hypothesis that LAN in older age is associated with higher prevalence of individual CVD… Continue reading Light at night in older age is associated with obesity, diabetes, and hypertension
Efficacy of very low calorie ketogenic diet in obese PCOS: a randomized controlled study
Background: Very low-calorie ketogenic diet (VLCKD) was shown to be effective in reducing weight and insulin resistance (IR) in obese patients. Considering that IR is very common in women with polycystic ovary syndrome (PCOS), and that IR worsens hyperandrogenism, ovulatory disfunction, and body fat accumulation, conceivably VLCKD could alleviate PCOS manifestations in the obese phenotype.… Continue reading Efficacy of very low calorie ketogenic diet in obese PCOS: a randomized controlled study
Longitudinal associations of childhood fitness and obesity profiles with midlife cognitive function: an Australian cohort study
ObjectivesClusters of low fitness and high obesity in childhood are associated with poorer health outcomes in later life, however their relationship with cognition is unknown. Identifying such profiles may inform strategies to reduce risk of cognitive decline. This study examined whether specific profiles of childhood fitness and obesity were associated with midlife cognition. DesignProspective study.… Continue reading Longitudinal associations of childhood fitness and obesity profiles with midlife cognitive function: an Australian cohort study
Association of Bariatric Surgery With Cancer Risk and Mortality in Adults With Obesity
Importance Obesity increases the incidence and mortality from some types of cancer, but it remains uncertain whether intentional weight loss can decrease this risk. Objective To investigate whether bariatric surgery is associated with lower cancer risk and mortality in patients with obesity. Design, Setting, and Participants In the SPLENDID (Surgical Procedures and Long-term Effectiveness in… Continue reading Association of Bariatric Surgery With Cancer Risk and Mortality in Adults With Obesity
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