The meta-analysis aimed to investigate the association of visceral fat area (VFA), waist circumference (WC), waist-hip ratio (WHR) and waist-height ratio (WHtR) with diabetic kidney disease (DKD) in type 2 diabetic patients. Methods: Included studies were searched from Pubmed, Embase, and the Cochrane Library before July 2020. We synthesized the pooled results of the above… Continue reading Meta-Analysis of the Relationship between Abdominal #Obesity and Diabetic #Kidney Disease in Type 2 #Diabetic Patients
Tag: Obese
Effect of #bariatric surgery on ischemic #stroke risk
Bariatric surgery has demonstrated improvements in cardiovascular health. The effect on ischemic stroke risk remains unclear. The goal of this study was to compare the risk of stroke among bariatric surgery patients versus controls. MethodsUsing Mariner, a national all-payer claims database, we identified patients with BMI > 40, or BMI > 35 with qualifying comorbidities… Continue reading Effect of #bariatric surgery on ischemic #stroke risk
Prevalence of increased #transaminases and its association with sex, age, and #metabolic parameters in children and adolescents wit7h obesity – a nationwide cross-sectional cohort study
Childhood obesity increases the risk of non-alcoholic fatty liver disease marked by elevated alanine aminotransferase (ALT). This study investigated the prevalence of increased ALT in children and adolescents with obesity, and its associations with sex, age, degree of obesity, and metabolic parameters. MethodsIndividuals between 5 and 17.99 years of age enrolled in the Swedish Childhood Obesity… Continue reading Prevalence of increased #transaminases and its association with sex, age, and #metabolic parameters in children and adolescents wit7h obesity – a nationwide cross-sectional cohort study
Evidence for a causal association between #milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals
High milk intake has been associated with cardio-metabolic risk. We conducted a Mendelian Randomization (MR) study to obtain evidence for the causal relationship between milk consumption and cardio-metabolic traits using the lactase persistence (LCT-13910 C > T, rs4988235) variant as an instrumental variable. MethodsWe tested the association of LCT genotype with milk consumption (for validation) and with… Continue reading Evidence for a causal association between #milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals
#Cognitive Behavioral Approach to Treat #Obesity: A Randomized Clinical Trial
Our aim was to analyze and compare the effects of three different long-term treatments on anthropometric profiles, eating behaviors, anxiety and depression levels, and quality of life of groups of adults with obesity. Methods: The 43 participants in the study were randomly assigned to one of three groups: the education and health group (EH, n… Continue reading #Cognitive Behavioral Approach to Treat #Obesity: A Randomized Clinical Trial
#Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With #Cardiovascular Disease
Obesity is associated with increased cardiovascular risk; however, the potential role of dysregulations in the adipose tissue (AT) metabolome is unknown. ObjectivesThe aim of this study was to explore the role of dysregulation in the AT metabolome on vascular redox signaling and cardiovascular outcomes. MethodsA screen was conducted for metabolites differentially secreted by thoracic AT… Continue reading #Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With #Cardiovascular Disease
Peripheral-specific Y1 receptor antagonism increases #thermogenesis and protects against diet-induced #obesity
Obesity is caused by an imbalance between food intake and energy expenditure (EE). Here we identify a conserved pathway that links signalling through peripheral Y1 receptors (Y1R) to the control of EE. Selective antagonism of peripheral Y1R, via the non-brain penetrable antagonist BIBO3304, leads to a significant reduction in body weight gain due to enhanced… Continue reading Peripheral-specific Y1 receptor antagonism increases #thermogenesis and protects against diet-induced #obesity
#Calcium Intake Is Inversely Related to Risk of #Obesity among American Young Adults over a 30-Year Follow-Up
Calcium (Ca) is an essential nutrient that may play an important role in weight maintenance through its involvement in energy or lipid metabolism. However, little is known about the long-term associations of Ca intake with obesity risk. ObjectivesWe aimed to prospectively examine the association between cumulative Ca intake and the incidence of obesity among American… Continue reading #Calcium Intake Is Inversely Related to Risk of #Obesity among American Young Adults over a 30-Year Follow-Up
Associations between #body-mass index and #COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study
Obesity is a major risk factor for adverse outcomes after infection with SARS-CoV-2. We aimed to examine this association, including interactions with demographic and behavioural characteristics, type 2 diabetes, and other health conditions. MethodsIn this prospective, community-based, cohort study, we used de-identified patient-level data from the QResearch database of general practices in England, UK. We… Continue reading Associations between #body-mass index and #COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study
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