Complex diseases, such as coronary artery disease (CAD), are often multifactorial, caused by multiple underlying pathological mechanisms. Here, to study the multifactorial nature of CAD, we performed comprehensive clinical and multi-omic profiling, including serum metabolomics and gut microbiome data, for 199 patients with acute coronary syndrome (ACS) recruited from two major Israeli hospitals, and validated… Continue reading Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease
Tag: microbiome
Charting host-microbe co-metabolism in #skin #aging and application to metagenomics data
During aging of human skin, a number of intrinsic and extrinsic factors cause the alteration of the skin’s structure, function and cutaneous physiology. Many studies have investigated the influence of the skin microbiome on these alterations, but the molecular mechanisms that dictate the interplay between these factors and the skin microbiome are still not fully… Continue reading Charting host-microbe co-metabolism in #skin #aging and application to metagenomics data
Dietary #spinach reshapes the gut #microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics
ABSTRACTComplex interrelationships govern the dynamic interactions between gut microbes, the host, and exogenous drivers of disease outcome. A multi-omics approach to cancer prevention by spinach (SPI) was pursued for the first time in the polyposis in rat colon (Pirc) model. SPI fed for 26 weeks (10% w/w, freeze-dried in the diet) exhibited significant antitumor efficacy… Continue reading Dietary #spinach reshapes the gut #microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics
#Dysbiosis of the gut microbiome impairs mouse skeletal #muscle adaptation to exercise
Dysbiosis of the gut microbiome caused by continuous antibiotic treatment did not affect running activity.Continuous treatment with antibiotics did not result in systemic inflammation as indicated by serum cytokine levels.Gut microbiome dysbiosis was associated with blunted fiber-type specific hypertrophy in the soleus and plantaris muscles in response to progressive weighted wheel running (PoWeR).Gut microbiome dysbiosis… Continue reading #Dysbiosis of the gut microbiome impairs mouse skeletal #muscle adaptation to exercise
The oral #microbiome in early #rheumatoid arthritis patients and individuals at risk differs from healthy controls
It has been suggested that rheumatoid arthritis (RA) may originate at the oral mucosa. Our aim was to assess the oral microbiome and the periodontal condition in patients with early rheumatoid arthritis (ERA) and individuals at risk of RA. MethodsThree groups were recruited (50 participants each): (1) ERA patients (2010 ACR/EULAR criteria), (2) at‐risk individuals… Continue reading The oral #microbiome in early #rheumatoid arthritis patients and individuals at risk differs from healthy controls
Long-term #dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut #microbiome
The microbiome directly affects the balance of pro-inflammatory and anti-inflammatory responses in the gut. As microbes thrive on dietary substrates, the question arises whether we can nourish an anti-inflammatory gut ecosystem. We aim to unravel interactions between diet, gut microbiota and their functional ability to induce intestinal inflammation. Design We investigated the relation between 173… Continue reading Long-term #dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut #microbiome
Cross-kingdom inhibition of bacterial virulence and communication by probiotic #yeast metabolites
Probiotic milk-fermented microorganism mixtures (e.g., yogurt, kefir) are perceived as contributing to human health, and possibly capable of protecting against bacterial infections. Co-existence of probiotic microorganisms are likely maintained via complex biomolecular mechanisms, secreted metabolites mediating cell-cell communication, and other yet-unknown biochemical pathways. In particular, deciphering molecular mechanisms by which probiotic microorganisms inhibit proliferation of… Continue reading Cross-kingdom inhibition of bacterial virulence and communication by probiotic #yeast metabolites
High-#Fiber, Whole-Food Dietary Intervention Alters the Human Gut #Microbiome but Not Fecal Short-Chain Fatty Acids
Dietary shifts can have a direct impact on the gut microbiome by preferentially selecting for microbes capable of utilizing the various dietary nutrients. The intake of dietary fiber has decreased precipitously in the last century, while consumption of processed foods has increased. Fiber, or microbiota-accessible carbohydrates (MACs), persist in the digestive tract and can be… Continue reading High-#Fiber, Whole-Food Dietary Intervention Alters the Human Gut #Microbiome but Not Fecal Short-Chain Fatty Acids
#Probiotic Properties of #Escherichia coli Nissle in Human Intestinal Organoids
Probiotic, or beneficial, bacteria, such as E. coli Nissle, hold promise for the treatment of human disease. More study is needed to fully realize the potential of probiotics. Safety and efficacy studies are critically important; however, mice are poor models for many human intestinal diseases. We used stem cell-derived human intestinal organoid tissues to evaluate… Continue reading #Probiotic Properties of #Escherichia coli Nissle in Human Intestinal Organoids
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