AbstractBackgroundLow vitamin D status is often associated with systemic low-grade inflammation as reflected by elevated C-reactive protein (CRP) levels. We investigated the causality and direction of the association between vitamin D status and CRP using linear and non-linear Mendelian randomization (MR) analyses.MethodsMR analyses were conducted using data from 294 970 unrelated participants of White-British ancestry from… Continue reading Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study
Tag: inflammation
Early life inflammation is associated with spinal cord excitability and nociceptive sensitivity in human infants
Immune function and sensitivity to pain are closely related, but the association between early life inflammation and sensory nervous system development is poorly understood—especially in humans. Here, in term-born infants, we measure brain activity and reflex withdrawal activity (using EEG and EMG) and behavioural and physiological activity (using the PIPP-R score) to assess the impact… Continue reading Early life inflammation is associated with spinal cord excitability and nociceptive sensitivity in human infants
Identification of gut microbial species linked with disease variability in a widely used mouse model of colitis
Experimental mouse models are central to basic biomedical research; however, variability exists across genetically identical mice and mouse facilities making comparisons difficult. Whether specific indigenous gut bacteria drive immunophenotypic variability in mouse models of human disease remains poorly understood. We performed a large-scale experiment using 579 genetically identical laboratory mice from a single animal facility, designed… Continue reading Identification of gut microbial species linked with disease variability in a widely used mouse model of colitis
SARS-CoV-2 vaccines: Lights and shadows
Highglights• So far, vaccines to prevent SARS-CoV-2 infection appear as promising approach for curbing the pandemic. • Vaccines for SARS-CoV-2 are being developed using several different platforms. • Some concerns have been raised regarding the safety of SARS-CoV-2 vaccines on the basis of rare adverse reactions, particularly thromboembolic. • The applicability to the real life… Continue reading SARS-CoV-2 vaccines: Lights and shadows
The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids
The endocannabinoid (EC) system has pleiotropic functions in the body. It plays a key role in energy homeostasis and the development of metabolic disorders being a mediator in the relationship between the gut microbiota and host metabolism. In the current study we explore the functional interactions between the endocannabinoid system and the gut microbiome in… Continue reading The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids
#EPA and #DHA differentially modulate monocyte #inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid mediators: A randomized, double-blind, crossover study
The independent effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on chronic inflammation through their downstream lipid mediators, including the specialized pro-resolving lipid mediators (SPM), remain unstudied. Therefore, we compared the effects of EPA and DHA supplementation on monocyte inflammatory response and plasma polyunsaturated fatty acids (PUFA) SPM lipidome.. After a 4-week lead-in phase… Continue reading #EPA and #DHA differentially modulate monocyte #inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid mediators: A randomized, double-blind, crossover study
Interrelationships between small airways dysfunction, neutrophilic #inflammation and exacerbation frequency in #COPD
Small airways disease (SAD) is a key component of COPD and is a main contributing factor to lung function decline.. ..Thirty nine COPD subjects defined as either frequent exacerbators ( ≥ 2 exacerbations per year, n = 17) and infrequent exacerbators (≤1 exacerbation per year, n = 22) underwent Forced Oscillation Technique (R5-R19, AX), multiple… Continue reading Interrelationships between small airways dysfunction, neutrophilic #inflammation and exacerbation frequency in #COPD
Distinct #inflammatory profiles distinguish #COVID-19 from #influenza with limited contributions from #cytokine storm
We pursued a study of immune responses in COVID-19 and influenza cohorts. Compared to influenza patients, COVID-19 patients exhibited largely equivalent lymphocyte counts, fewer monocytes, and lower surface HLA-class II expression on select monocyte populations. Furthermore, decreased HLA-DR on intermediate monocytes was a significant predictor of COVID-19 disease severity. In contrast to prevailing assumptions about… Continue reading Distinct #inflammatory profiles distinguish #COVID-19 from #influenza with limited contributions from #cytokine storm
#Dietary Inflammatory Potential and Risk of #Cardiovascular Disease Among Men and Women in the U.S.
Inflammation plays an important role in cardiovascular disease (CVD) development. Diet modulates inflammation; however, it remains unknown whether dietary patterns with higher inflammatory potential are associated with long-term CVD risk We prospectively followed 74,578 women from the Nurses’ Health Study (NHS) (1984–2016), 91,656 women from the NHSII (1991–2015), and 43,911 men from the Health Professionals… Continue reading #Dietary Inflammatory Potential and Risk of #Cardiovascular Disease Among Men and Women in the U.S.
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