BackgroundSudden cardiac arrest is a global public health problem with a mortality rate of more than 90%. Prearrest warning symptoms could be harnessed using digital technology to potentially improve survival outcomes. We aimed to estimate the strength of association between symptoms and imminent sudden cardiac arrest.MethodsWe conducted a case-control study of individuals with sudden cardiac… Continue reading Warning symptoms associated with imminent sudden #cardiac arrest: a population-based case-control study with external validation
High #ultra-processed food consumption is associated with elevated #psychological distress as an indicator of #depression in adults from the Melbourne Collaborative Cohort Study
Highlights•Participants with the highest intake of ultra-processed food had increased odds of elevated psychological distress•We found no evidence for an interaction of sex, age and body mass index with ultra-processed food intake•Further research is needed to better inform nutrition-related and public health strategies for mental health BackgroundFew studies have tested longitudinal associations between ultra-processed food… Continue reading High #ultra-processed food consumption is associated with elevated #psychological distress as an indicator of #depression in adults from the Melbourne Collaborative Cohort Study
Effects of adult #education on #cognitive function and risk of #dementia in older adults: a longitudinal analysis
Introduction: Mid/late-life cognitive activities are associated with a lower rate of subsequent cognitive decline and lower subsequent dementia risk over time.Methods: In this study, we investigated the association between adult education class participation and subsequent cognitive decline and dementia risk over time after adjusting for baseline cognitive function and genetic risk of dementia, correcting for several potential… Continue reading Effects of adult #education on #cognitive function and risk of #dementia in older adults: a longitudinal analysis
Effect of Vitamin #D Supplements on Relapse or Death in a p53-Immunoreactive Subgroup With #Digestive Tract Cancer
Recent meta-analyses of randomized clinical trials found that daily vitamin D3 supplementation had beneficial effects on cancer mortality, although the results are still controversial.Objective To examine whether vitamin D supplementation reduces the risk of relapse or death in a supgroup of patients with digestive tract cancer who were p53 immunoreactive.Design, Setting, and Participants This was a post… Continue reading Effect of Vitamin #D Supplements on Relapse or Death in a p53-Immunoreactive Subgroup With #Digestive Tract Cancer
Long-term #cancer outcomes after #bariatric surgery
ObjectiveObesity is associated with increased cancer risk. Because of the substantial and sustained weight loss following bariatric surgery, postsurgical patients are ideal to study the association of weight loss and cancer.MethodsRetrospectively (1982–2019), 21,837 bariatric surgery patients (surgery, 1982–2018) were matched 1:1 by age, sex, and BMI with a nonsurgical comparison group. Procedures included gastric bypass,… Continue reading Long-term #cancer outcomes after #bariatric surgery
Interaction of an α-synuclein epitope with HLA-DRB1∗15:01 triggers enteric features in mice reminiscent of prodromal #Parkinson’s disease
•α-syn32-46 immunization of HLA-DRB1∗15:01 mice triggers weight loss and constipation•α-syn32-46 immunizations induce inflammation and neuron loss in the gut•Depletion of CD4+, but not CD8+, T cells partially rescues enteric neural loss•Both α-syn32-46 and HLA-DRB1∗15:01 are critical for this model of prodromal PD SummaryEnteric symptoms are hallmarks of prodromal Parkinson’s disease (PD) that appear decades before the onset of motor… Continue reading Interaction of an α-synuclein epitope with HLA-DRB1∗15:01 triggers enteric features in mice reminiscent of prodromal #Parkinson’s disease
Higher working #memory capacity and distraction-resistance associated with strategy (not action) #game playing in younger adults, but #puzzle game playing in older adults
Superior attention and Working Memory (WM) have been reported for habitual action video gamers compared to other gamers or non-players. With an online experiment we measured visuo-spatial WM capacity and ability to ignore distraction, and participants listed the video games they played. Categorising the 209 young adult participants (18–30 years) according to the game type… Continue reading Higher working #memory capacity and distraction-resistance associated with strategy (not action) #game playing in younger adults, but #puzzle game playing in older adults
Speakers of different #languages remember #visual scenes differently
Language can have a powerful effect on how people experience events. Here, we examine how the languages people speak guide attention and influence what they remember from a visual scene. When hearing a word, listeners activate other similar-sounding words before settling on the correct target. We tested whether this linguistic coactivation during a visual search… Continue reading Speakers of different #languages remember #visual scenes differently
American #Football Play and #Parkinson Disease Among Men
Importance Parkinsonism and Parkinson disease (PD) are known to result from repetitive head impacts from boxing. Repetitive head impacts from American football may also be associated with increased risk of neurodegenerative pathologies that cause parkinsonism, yet in vivo research on the association between football play and PD is scarce and limited by small samples and equivocal… Continue reading American #Football Play and #Parkinson Disease Among Men
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