Lifestyle change plays a crucial role in the prevention and treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). In recent years, diet soft drinks that emphasize “zero sugar and zero calories” have become all the rage, but whether diet soft drink consumption is associated with MASLD is not clear.MethodsThis study included data from the National… Continue reading Association between diet soft #drink consumption and #metabolic dysfunction-associated #steatotic liver disease: findings from the NHANES
#Choroidal and #retinal thinning in chronic #kidney disease independently associate with eGFR decline and are modifiable with treatment
In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers that reliably track kidney injury, demonstrate treatment-response, and predict outcomes. Here, we investigate the potential of retinal optical coherence tomography (OCT) to achieve these ends in a series of prospective studies of patients with pre-dialysis CKD (including those with a… Continue reading #Choroidal and #retinal thinning in chronic #kidney disease independently associate with eGFR decline and are modifiable with treatment
Silver─Gallium Nano-Amalgamated Particles as a Novel, Biocompatible Solution for #Antibacterial Coatings
Bacterial infections account for countless deaths globally. Antibiotics are the primary countermeasure; however, the alarming spread of antibiotic-resistant strains necessitates alternative solutions. Silver and silver compounds have emerged as promising antibacterial agents. However, issues related to cytotoxicity and genotoxicity of silver remain concern. To overcome these challenges, this proposes an easy-to-control and straightforward method to… Continue reading Silver─Gallium Nano-Amalgamated Particles as a Novel, Biocompatible Solution for #Antibacterial Coatings
Examining the Association between #Coffee Intake and the Risk of Developing #Irritable #Bowel Syndrome: A Systematic Review and Meta-Analysis
Abstract: Irritable bowel syndrome (IBS) is a highly prevalent disorder of braingut interaction with a significant impact on quality of life. Coffee is a widely consumed beverage with numerous bioactive compounds that have potential effects on human health and disease states. Current studies on the effect of regular coffee consumption on the risk of developing… Continue reading Examining the Association between #Coffee Intake and the Risk of Developing #Irritable #Bowel Syndrome: A Systematic Review and Meta-Analysis
#Walking speed and the risk of type 2 #diabetes: a systematic review and meta-analysis
Objective To investigate the association between walking speed and the risk of type 2 diabetes.Design Systematic review and meta-analysis.Data sources PubMed, Scopus, CENTRAL and Web of Science to 30 May 2023.Eligibility criteria for selecting studies We included cohort studies that explored the association between walking speed and the risk of type 2 diabetes in adults. We used random-effects meta-analyses… Continue reading #Walking speed and the risk of type 2 #diabetes: a systematic review and meta-analysis
Elucidating regulatory processes of intense #physical activity by multi-omics analysis
BackgroundPhysiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations, such as firefighting, law enforcement, military, and sports. A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work environment.MethodsTo study regulatory processes in… Continue reading Elucidating regulatory processes of intense #physical activity by multi-omics analysis
Enhancing Vision: Exploring the Link Between Vitamin #C and Reduced #Cataract Risks – A Physician’s Perspective
As physicians continually explore avenues for promoting overall health, recent research has shed light on a potential ally in the fight against cataracts – Vitamin C. This essential nutrient, long celebrated for its immune-boosting properties, is now gaining recognition for its potential role in reducing the risk of cataract development. In this blog post, I… Continue reading Enhancing Vision: Exploring the Link Between Vitamin #C and Reduced #Cataract Risks – A Physician’s Perspective
Vitamin #B12 is a limiting factor for induced cellular plasticity and #tissue repair
Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its metabolic requirements. Here we show that OSKM reprogramming in mice causes a global depletion of vitamin B12 and molecular hallmarks of methionine starvation. Supplementation with vitamin B12 increases the efficiency… Continue reading Vitamin #B12 is a limiting factor for induced cellular plasticity and #tissue repair
Multi-omic network analysis identified #betacellulin as a novel target of #omega-3 fatty acid attenuation of western diet-induced nonalcoholic #steatohepatitis
Clinical and preclinical studies established that supplementing diets with ω3 polyunsaturated fatty acids (PUFA) can reduce hepatic dysfunction in nonalcoholic steatohepatitis (NASH) but molecular underpinnings of this action were elusive. Herein, we used multi-omic network analysis that unveiled critical molecular pathways involved in ω3 PUFA effects in a preclinical mouse model of western diet induced… Continue reading Multi-omic network analysis identified #betacellulin as a novel target of #omega-3 fatty acid attenuation of western diet-induced nonalcoholic #steatohepatitis
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