Insulin secretion to 3 model macronutrients in 140 human islet donors is defined•Deep phenotyping and multi-omics reveal personalized nutrient-specific insulin release•A subset of donors with a unique proteome exhibits large insulin responses to lipids•Nutrient responsiveness in stem cell-derived islets is dysregulatedSummaryPopulation-level variation and mechanisms behind insulin secretion in response to carbohydrate, protein, and fat remain… Continue reading Proteomic predictors of individualized nutrient-specific #insulin secretion in #health and #disease
Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of #Dementia With #Lewy Bodies in Men
Background and ObjectivesTerazosin, doxazosin, and alfuzosin (Tz/Dz/Az) are α-1 adrenergic receptor antagonists that also bind to and activate a key adenosine triphosphate (ATP)–producing enzyme in glycolysis. It is hypothesized that the increase in energy availability in the brain may slow or prevent neurodegeneration, potentially by reducing the accumulation of alpha-synuclein. Recent work has suggested a… Continue reading Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of #Dementia With #Lewy Bodies in Men
Changes in prevalence and incidence of #dementia and risk factors for dementia: an analysis from cohort studies
BackgroundSome cohort studies have reported a decline in dementia prevalence and incidence over time, although these findings have not been consistent across studies. We reviewed evidence on changes in dementia prevalence and incidence over time using published population-based cohort studies that had used consistent methods with each wave and aimed to quantify associated changes in… Continue reading Changes in prevalence and incidence of #dementia and risk factors for dementia: an analysis from cohort studies
Genome-wide association studies of #coffee intake in UK/US participants of European ancestry uncover cohort-specific #genetic associations
Coffee is one of the most widely consumed beverages. We performed a genome-wide association study (GWAS) of coffee intake in US-based 23andMe participants (N = 130,153) and identified 7 significant loci, with many replicating in three multi-ancestral cohorts. We examined genetic correlations and performed a phenome-wide association study across hundreds of biomarkers, health, and lifestyle traits, then… Continue reading Genome-wide association studies of #coffee intake in UK/US participants of European ancestry uncover cohort-specific #genetic associations
Associations of #sex-related and #thyroid-related #hormones with risk of metabolic dysfunction-associated fatty #liver disease in T2DM patients
BackgroundWe aimed to examine sex-specific associations between sex- and thyroid-related hormones and the risk of metabolic dysfunction-associated fatty liver disease (MAFLD) in patients with type 2 diabetes mellitus (T2DM)MethodsCross-sectional analyses of baseline information from an ongoing cohort of 432 T2DM patients (185 women and 247 men) in Xiamen, China were conducted. Plasma sex-related hormones, including… Continue reading Associations of #sex-related and #thyroid-related #hormones with risk of metabolic dysfunction-associated fatty #liver disease in T2DM patients
Association of #Terazosin, #Doxazosin, or #Alfuzosin Use and Risk of #Dementia With Lewy Bodies in Men
Background and ObjectivesTerazosin, doxazosin, and alfuzosin (Tz/Dz/Az) are α-1 adrenergic receptor antagonists that also bind to and activate a key adenosine triphosphate (ATP)–producing enzyme in glycolysis. It is hypothesized that the increase in energy availability in the brain may slow or prevent neurodegeneration, potentially by reducing the accumulation of alpha-synuclein. Recent work has suggested a… Continue reading Association of #Terazosin, #Doxazosin, or #Alfuzosin Use and Risk of #Dementia With Lewy Bodies in Men
#Stress -resilience impacts psychological wellbeing as evidenced by brain–gut #microbiome interactions
The brain–gut microbiome (BGM) system plays an influential role on mental health. We characterized BGM patterns related to resilience using fecal samples and multimodal magnetic resonance imaging. Data integration analysis using latent components showed that the high-resilience phenotype was associated with lower depression and anxiety symptoms, higher frequency of bacterial transcriptomes (related to environmental adaptation,… Continue reading #Stress -resilience impacts psychological wellbeing as evidenced by brain–gut #microbiome interactions
Posttraumatic #Stress Disorder and Obstructive Sleep #Apnea in Twins
Key PointsQuestion What is the association of posttraumatic stress disorder (PTSD) with obstructive sleep apnea (OSA) after accounting for acknowledged medical risk factors for OSA?Findings In a cross-sectional study of 132 older male veteran twins discordant for PTSD undergoing in-laboratory polysomnography, current PTSD diagnosis and symptoms were associated independently with OSA, even after controlling for demographics, behavioral… Continue reading Posttraumatic #Stress Disorder and Obstructive Sleep #Apnea in Twins
Premenopausal bilateral #oophorectomy and #brain white matter brain integrity in later-life
INTRODUCTIONPremenopausal bilateral oophorectomy (PBO) is associated with later-life cognition, but the underlying brain changes remain unclear. We assessed the impact of PBO and PBO age on white matter integrity.METHODSFemale participants with regional diffusion tensor imaging (DTI) metrics of fractional anisotropy (FA) and mean diffusivity (MD) were included (22 with PBO < 40 years; 43 with PBO 40-45… Continue reading Premenopausal bilateral #oophorectomy and #brain white matter brain integrity in later-life
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