Importance Excessive screen media use has been associated with poorer mental health among children and adolescents in several observational studies. However, experimental evidence supporting this hypothesis is lacking.Objective To investigate the effects of a 2-week screen media reduction intervention on children’s and adolescents’ mental health.Design, Setting, and Participants This prespecified secondary analysis of a cluster randomized clinical trial… Continue reading #Screen Media Use and #Mental Health of Children and AdolescentsA Secondary Analysis of a Randomized Clinical Trial
Molecular dissection of cobra #venom highlights #heparinoids as an antidote for spitting cobra envenoming
Editor’s summarySnakebite is considered a neglected tropical disease by the World Health Organization, and although antibody-based antivenoms exist, they are species specific, are expensive, and require cold storage as well as intravenous administration in a health care setting. Here, Du and colleagues conducted a whole-genome CRISPR knockout screen to identify genes required for spitting cobra… Continue reading Molecular dissection of cobra #venom highlights #heparinoids as an antidote for spitting cobra envenoming
#Diet shapes the metabolite profile in the intact human ileum, which affects PYY release
The human ileum contains a high density of enteroendocrine L-cells, which release the appetite-suppressing hormones glucagon-like peptide-1 (GLP-1) and peptide tyrosine tyrosine (PYY) in response to food intake. Recent evidence highlighted the potential role of food structures in PYY release, but the link between food structures, ileal metabolites, and appetite hormone release remains unclear owing… Continue reading #Diet shapes the metabolite profile in the intact human ileum, which affects PYY release
#Lipidome changes due to improved dietary #fat quality inform cardiometabolic risk reduction and precision #nutrition
Current cardiometabolic disease prevention guidelines recommend increasing dietary unsaturated fat intake while reducing saturated fats. Here we use lipidomics data from a randomized controlled dietary intervention trial to construct a multilipid score (MLS), summarizing the effects of replacing saturated fat with unsaturated fat on 45 lipid metabolite concentrations. In the EPIC-Potsdam cohort, a difference in… Continue reading #Lipidome changes due to improved dietary #fat quality inform cardiometabolic risk reduction and precision #nutrition
Prevalence of #irritable bowel syndrome and functional $dyspepsia after acute #gastroenteritis: systematic review and meta-analysis
Objective Disorders of gut-brain interaction may arise after acute gastroenteritis. Data on the influence of pathogen type on the risk of postinfection IBS (PI-IBS), as on postinfection functional dyspepsia (PI-FD), are limited. We conducted a systematic review and meta-analysis to determine prevalence of PI-IBS or PI-FD after acute gastroenteritis.Design We included observational studies recruiting ≥50 adults and… Continue reading Prevalence of #irritable bowel syndrome and functional $dyspepsia after acute #gastroenteritis: systematic review and meta-analysis
#Antibiotic-driven #dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates #allergic airway inflammation in adulthood
•Early-life antibiotics increase the risk of allergy in adulthood•Antibiotics cause short-term disruption of the microbiome and systemic metabolome•Dysfunctional mitochondria in the airway epithelium lead to exaggerated inflammation•Indole-3-propionic acid counters the detrimental effects of early-life antibioticsSummaryAntibiotic use in early life disrupts microbial colonization and increases the risk of developing allergies and asthma. We report that mice… Continue reading #Antibiotic-driven #dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates #allergic airway inflammation in adulthood
Efficacy of #Atogepant in Chronic #Migraine With and Without Acute Medication Overuse in the Randomized, Double-Blind, Phase 3 PROGRESS Trial
AbstractBackground and ObjectivesAtogepant is an oral, calcitonin gene-related peptide receptor antagonist approved for the preventive treatment of migraine. We evaluated the efficacy of atogepant for the preventive treatment of chronic migraine (CM) in participants with and without acute medication overuse.MethodsThis subgroup analysis of the phase 3, 12-week, randomized, double-blind, placebo-controlled PROGRESS trial evaluated adults with… Continue reading Efficacy of #Atogepant in Chronic #Migraine With and Without Acute Medication Overuse in the Randomized, Double-Blind, Phase 3 PROGRESS Trial
Metabolic effects of very-low calorie #diet, #Semaglutide, or combination of the two, in individuals with type 2 #diabetes mellitus
Background & aimsVery-low calorie diets (VLCD) and the glucagon-like peptide-1 receptor agonist (GLP1RA) Semaglutide induce significant weight loss and improve glycaemic control in individuals with type 2 diabetes (T2D). This pilot study was conducted to explore the comparative short-term effects of these interventions individually, and in combination, on weight, body composition and metabolic outcomes.MethodsThirty individuals… Continue reading Metabolic effects of very-low calorie #diet, #Semaglutide, or combination of the two, in individuals with type 2 #diabetes mellitus
Nasal tau #immunotherapy clears intracellular #tau pathology and improves cognitive functions in aged tauopathy mice
Editor’s summaryTau pathology is a common denominator for neurodegenerative diseases such as Alzheimer’s disease or frontotemporal dementia, but selectively targeting toxic tau remains a challenge. Here, Gaikwad et al. developed a conformation-specific antibody for tau and demonstrated selective targeting of toxic tau aggregates in patient-derived tissue and tau oligomers in vitro. Packed into lipophile micelles, the antibody… Continue reading Nasal tau #immunotherapy clears intracellular #tau pathology and improves cognitive functions in aged tauopathy mice
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