Coffee is one of the most widely consumed beverages. We performed a genome-wide association study (GWAS) of coffee intake in US-based 23andMe participants (N = 130,153) and identified 7 significant loci, with many replicating in three multi-ancestral cohorts. We examined genetic correlations and performed a phenome-wide association study across hundreds of biomarkers, health, and lifestyle traits, then… Continue reading Genome-wide association studies of #coffee intake in UK/US participants of European ancestry uncover cohort-specific #genetic associations
Associations of #sex-related and #thyroid-related #hormones with risk of metabolic dysfunction-associated fatty #liver disease in T2DM patients
BackgroundWe aimed to examine sex-specific associations between sex- and thyroid-related hormones and the risk of metabolic dysfunction-associated fatty liver disease (MAFLD) in patients with type 2 diabetes mellitus (T2DM)MethodsCross-sectional analyses of baseline information from an ongoing cohort of 432 T2DM patients (185 women and 247 men) in Xiamen, China were conducted. Plasma sex-related hormones, including… Continue reading Associations of #sex-related and #thyroid-related #hormones with risk of metabolic dysfunction-associated fatty #liver disease in T2DM patients
Association of #Terazosin, #Doxazosin, or #Alfuzosin Use and Risk of #Dementia With Lewy Bodies in Men
Background and ObjectivesTerazosin, doxazosin, and alfuzosin (Tz/Dz/Az) are α-1 adrenergic receptor antagonists that also bind to and activate a key adenosine triphosphate (ATP)–producing enzyme in glycolysis. It is hypothesized that the increase in energy availability in the brain may slow or prevent neurodegeneration, potentially by reducing the accumulation of alpha-synuclein. Recent work has suggested a… Continue reading Association of #Terazosin, #Doxazosin, or #Alfuzosin Use and Risk of #Dementia With Lewy Bodies in Men
#Stress -resilience impacts psychological wellbeing as evidenced by brain–gut #microbiome interactions
The brain–gut microbiome (BGM) system plays an influential role on mental health. We characterized BGM patterns related to resilience using fecal samples and multimodal magnetic resonance imaging. Data integration analysis using latent components showed that the high-resilience phenotype was associated with lower depression and anxiety symptoms, higher frequency of bacterial transcriptomes (related to environmental adaptation,… Continue reading #Stress -resilience impacts psychological wellbeing as evidenced by brain–gut #microbiome interactions
Posttraumatic #Stress Disorder and Obstructive Sleep #Apnea in Twins
Key PointsQuestion What is the association of posttraumatic stress disorder (PTSD) with obstructive sleep apnea (OSA) after accounting for acknowledged medical risk factors for OSA?Findings In a cross-sectional study of 132 older male veteran twins discordant for PTSD undergoing in-laboratory polysomnography, current PTSD diagnosis and symptoms were associated independently with OSA, even after controlling for demographics, behavioral… Continue reading Posttraumatic #Stress Disorder and Obstructive Sleep #Apnea in Twins
Premenopausal bilateral #oophorectomy and #brain white matter brain integrity in later-life
INTRODUCTIONPremenopausal bilateral oophorectomy (PBO) is associated with later-life cognition, but the underlying brain changes remain unclear. We assessed the impact of PBO and PBO age on white matter integrity.METHODSFemale participants with regional diffusion tensor imaging (DTI) metrics of fractional anisotropy (FA) and mean diffusivity (MD) were included (22 with PBO < 40 years; 43 with PBO 40-45… Continue reading Premenopausal bilateral #oophorectomy and #brain white matter brain integrity in later-life
Self-administered #mindfulness interventions reduce #stress in a large, randomized controlled multi-site study
Mindfulness witnessed a substantial popularity surge in the past decade, especially as digitally self-administered interventions became available at relatively low costs. Yet, it is uncertain whether they effectively help reduce stress. In a preregistered (OSF https://doi.org/10.17605/OSF.IO/UF4JZ; retrospective registration at ClinicalTrials.gov NCT06308744) multi-site study (nsites = 37, nparticipants = 2,239, 70.4% women, Mage = 22.4, s.d.age = 10.1, all fluent English speakers), we experimentally tested whether four single,… Continue reading Self-administered #mindfulness interventions reduce #stress in a large, randomized controlled multi-site study
National, regional, and global trends in insufficient #physical activity among adults from 2000 to 2022: a pooled analysis of 507 population-based surveys with 5·7 million participants
BackgroundInsufficient physical activity increases the risk of non-communicable diseases, poor physical and cognitive function, weight gain, and mental ill-health. Global prevalence of adult insufficient physical activity was last published for 2016, with limited trend data. We aimed to estimate the prevalence of insufficient physical activity for 197 countries and territories, from 2000 to 2022.MethodsWe collated… Continue reading National, regional, and global trends in insufficient #physical activity among adults from 2000 to 2022: a pooled analysis of 507 population-based surveys with 5·7 million participants
Effectiveness and cost-effectiveness of an individualised, progressive #walking and education intervention for the prevention of low back #pain recurrence in Australia (WalkBack): a randomised controlled trial
BackgroundRecurrence of low back pain is common and a substantial contributor to the disease and economic burden of low back pain. Exercise is recommended to prevent recurrence, but the effectiveness and cost-effectiveness of an accessible and low-cost intervention, such as walking, is yet to be established. We aimed to investigate the clinical effectiveness and cost-effectiveness… Continue reading Effectiveness and cost-effectiveness of an individualised, progressive #walking and education intervention for the prevention of low back #pain recurrence in Australia (WalkBack): a randomised controlled trial
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