OBJECTIVEExtracellular lipoprotein aggregation is a critical event in AMD pathogenesis. In this study, we sought to analyze associations between clinical and genetic-based factors related to lipoprotein metabolism and risk for age-related macular degeneration (AMD) in the All of Us research program.DESIGNCross-sectional retrospective data analysis.SUBJECTS5028 healthy and 2328 AMD patients from All of Us.METHODSParticipants with and… Continue reading High Density #Lipoproteins Associate with Age-Related #Macular Degeneration in the All of Us Research Program
#Green tea consumption and #cerebral white matter lesions in community-dwelling older adults without dementia
This study investigated the association between green tea or coffee consumption with cerebral white matter lesions and hippocampal and total brain volumes among 8766 community-dwelling participants recruited from the Japan Prospective Studies Collaboration for Aging and Dementia between 2016 and 2018. A Food Frequency Questionnaire was used to assess green tea and coffee consumption, whereas… Continue reading #Green tea consumption and #cerebral white matter lesions in community-dwelling older adults without dementia
PIN1 prolyl isomerase promotes initiation and progression of #bladder cancer through the SREBP2-mediated #cholesterol biosynthesis pathway
Identities of functional pSer/Thr.Pro protein substrates of the PIN1 prolyl isomerase and its effects on downstream signaling in bladder carcinogenesis remain largely unknown. Phenotypically, we found that PIN1 positively regulated bladder cancer cell proliferation, cell motility and urothelium clearance capacity in vitro and controlled tumor growth and potential metastasis in vivo. Mechanistically, we observed a… Continue reading PIN1 prolyl isomerase promotes initiation and progression of #bladder cancer through the SREBP2-mediated #cholesterol biosynthesis pathway
Lifetime risk and projected burden of #dementia
The lifetime risk of dementia after age 55 years was 42% (95% confidence interval: 41–43). Rates were substantially higher in women, Black adults and APOE ε4 carriers, with lifetime risks ranging from approximately 45% to 60% in these populations. The number of US adults who will develop dementia each year was projected to increase from approximately… Continue reading Lifetime risk and projected burden of #dementia
Association between recorded #physical activity and cancer progression or mortality in individuals diagnosed with #cancer in South Africa
Objectives This study aimed to determine the association between progression and mortality in individuals with stage 1 cancer and their recorded physical activity before the diagnosis of the cancer.Methods We included 28 248 members with stage 1 cancers enrolled in an oncology programme in South Africa. Physical activity was recorded using fitness devices, logged gym sessions… Continue reading Association between recorded #physical activity and cancer progression or mortality in individuals diagnosed with #cancer in South Africa
Comparison between two divergent diets, #Mediterranean and #Western, on #gut #microbiota and cognitive function in young sprague dawley rats
Clinical studies strongly suggest the importance of diet quality on cognition in youth populations (15–24 years). The Mediterranean diet (MeDi) has been shown to improve cognition in contrast to the commonly consumed Western diet (WD). The gut microbiota may serve as a mechanism for diet-induced changes in cognition. Ten-week-old male Sprague Dawley rats were assigned a… Continue reading Comparison between two divergent diets, #Mediterranean and #Western, on #gut #microbiota and cognitive function in young sprague dawley rats
Transarterial #chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic #hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study
BackgroundTransarterial chemoembolisation (TACE) is standard care for unresectable, non-metastatic hepatocellular carcinoma. We aimed to evaluate the addition of lenvatinib and pembrolizumab to TACE versus dual placebo plus TACE in patients with unresectable, non-metastatic hepatocellular carcinoma.MethodsIn this multicentre, randomised, double-blind, phase 3 study (LEAP-012), patients were recruited from 137 global sites in 33 countries or regions.… Continue reading Transarterial #chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic #hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study
Coffee drinking timing and mortality in US adults
Background and Aims To identify the patterns of coffee drinking timing in the US population and evaluate their associations with all-cause and cause-specific mortality.Methods This study included 40 725 adults from the National Health and Nutrition Examination Survey 1999–2018 who had complete information on dietary data and 1463 adults from the Women’s and Men’s Lifestyle… Continue reading Coffee drinking timing and mortality in US adults
The massed-spaced #learning effect in non-neural human #cells
The massed-spaced effect is a hallmark feature of memory formation. We now demonstrate this effect in two separate non-neural, immortalized cell lines stably expressing a short-lived luciferase reporter controlled by a CREB-dependent promoter. We emulate training using repeated pulses of forskolin and/or phorbol ester, and, as a proxy for memory, measure luciferase expression at various… Continue reading The massed-spaced #learning effect in non-neural human #cells
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