Key PointsQuestion In older individuals with diabetes, is maintaining stability of glycated hemoglobin A1c levels (HbA1c) in individualized target ranges over time associated with lower risk of Alzheimer disease and related dementias (ADRD)?Findings In this cohort study of 374 021 older veterans with diabetes, greater HbA1c stability, as measured by HbA1c time in range, was associated with a lower risk of… Continue reading Glycated Hemoglobin A1c Time in Range and #Dementia in Older Adults With #Diabetes
Bilateral #Mastectomy and #Breast Cancer Mortality
Question Does bilateral mastectomy for treatment of unilateral breast cancer reduce the 20-year risk of breast cancer mortality?Findings This cohort study including 661 270 women with unilateral breast cancer who were closely matched by treatment type (lumpectomy, unilateral mastectomy, or bilateral mastectomy) and followed up for 20 years found that bilateral mastectomy was associated with a statistically significant… Continue reading Bilateral #Mastectomy and #Breast Cancer Mortality
Are Blood Tests for #Alzheimer Disease Ready for Prime Time?
This is a transformative time for patients with Alzheimer disease. Alzheimer disease is increasingly viewed as a treatable condition and managed like other major chronic diseases, such as heart disease and cancer. Management of Alzheimer disease includes early diagnosis with molecular confirmation, disease-modifying treatments that are initiated early in the disease course, better risk reduction… Continue reading Are Blood Tests for #Alzheimer Disease Ready for Prime Time?
The predictive validity of a #Brain Care Score for late-life #depression and a composite outcome of #dementia, #stroke, and late-life #depression: data from the UK Biobank cohort
Introduction: The 21-point Brain Care Score (BCS) is a novel tool designed to motivate individuals and care providers to take action to reduce the risk of stroke and dementia by encouraging lifestyle changes. Given that late-life depression is increasingly recognized to share risk factors with stroke and dementia, and is an important clinical endpoint for brain… Continue reading The predictive validity of a #Brain Care Score for late-life #depression and a composite outcome of #dementia, #stroke, and late-life #depression: data from the UK Biobank cohort
#Sex and mental #health are related to subcortical #brain microstructure
SignificanceWe demonstrate the presence of large sex-related differences in the microstructure of subcortical gray matter using advanced noninvasive diffusion MRI in a large cohort of young adults. These sex differences are found in several key brain structures that are important for mental health and are consistent with experimental studies in animals showing cellular differences in… Continue reading #Sex and mental #health are related to subcortical #brain microstructure
Impact of Plant-Based Dietary #Fibers on Metabolic Homeostasis in High-#Fat Diet Mice via Alterations in the Gut #Microbiota and Metabolites
BackgroundThe gut microbiota contributes to metabolic disease, and diet shapes the gut microbiota, emphasizing the need to better understand how diet impacts metabolic disease via gut microbiota alterations. Fiber intake is linked with improvements in metabolic homeostasis in rodents and humans, which is associated with changes in the gut microbiota. However, dietary fiber is extremely… Continue reading Impact of Plant-Based Dietary #Fibers on Metabolic Homeostasis in High-#Fat Diet Mice via Alterations in the Gut #Microbiota and Metabolites
Comprehensive assessment of #pesticide use patterns and increased #cancer risk
Pesticides are an essential feature of modern-day agriculture that adds to the list of factors that increase cancer risk. Our study aims to comprehensively evaluate this relationship through a population-based approach that considers confounding variables such as county-specific rates of smoking, socioeconomic vulnerability, and agricultural land. We achieved our goal with the implementation of latent-class… Continue reading Comprehensive assessment of #pesticide use patterns and increased #cancer risk
#Drone delivery of automated external #defibrillators compared with ambulance arrival in real-life suspected out-of-hospital cardiac arrests: a prospective observational study in Sweden
Background: A novel approach to improve bystander defibrillation for out-of-hospital cardiac arrests is to dispatch and deliver an automated external defibrillator (AED) directly to the suspected cardiac arrest location by drone. The aim of this study was to investigate how often a drone could deliver an AED before ambulance arrival and to measure the median time… Continue reading #Drone delivery of automated external #defibrillators compared with ambulance arrival in real-life suspected out-of-hospital cardiac arrests: a prospective observational study in Sweden
Healthy Prenatal #Dietary Pattern and Offspring #Autism
Question What is the association between a healthy prenatal dietary pattern and offspring autism diagnosis and autism-associated traits in 2 large prospective cohort studies: the Norwegian Mother, Father, and Child Cohort (MoBa) and the Avon Study of Parents and Children (ALSPAC)?Findings In this cohort study including 84 548 mother-infant dyads in MoBa and 11 670 mother-infant dyads in ALSPAC,… Continue reading Healthy Prenatal #Dietary Pattern and Offspring #Autism
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