Importance Aspirin reduces the risk of colorectal cancer (CRC). Identifying individuals more likely to benefit from regular aspirin use for CRC prevention is a high priority.Objective To assess whether aspirin use is associated with the risk of CRC across different lifestyle risk factors.Design, Setting, and Participants A prospective cohort study among women in the Nurses’ Health Study (1980-2018)… Continue reading #Aspirin Use and Incidence of #Colorectal Cancer According to Lifestyle Risk
Effect of #chair placement on physicians’ #behavior and patients’ satisfaction: randomized deception trial
Objective To evaluate the effect of chair placement on length of time physicians sit during a bedside consultation and patients’ satisfaction.Design Single center, double blind, randomized controlled deception trial.Setting County hospital in Texas, USA.Participants 51 hospitalist physicians providing direct care services, and 125 observed encounters of patients who could answer four orientation questions correctly before study entry, April 2022… Continue reading Effect of #chair placement on physicians’ #behavior and patients’ satisfaction: randomized deception trial
Estimated Exposure to 6 Potentially #Hepatotoxic Botanicals in US Adults
Importance Use of herbal and dietary supplements (HDSs) accounts for an increasing proportion of drug hepatotoxicity cases. Turmeric or curcumin, green tea extract, Garcinia cambogia, black cohosh, red yeast rice, and ashwagandha are the most frequently reported hepatoxic botanicals, but their prevalence and reasons for use in the general population are unknown.Objective To assess the prevalence and clinical… Continue reading Estimated Exposure to 6 Potentially #Hepatotoxic Botanicals in US Adults
ω-3 #PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older AdultsA Randomized Clinical Trial
Importance Older adults with lower intake and tissue levels of long-chain ω-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6) have more brain white matter lesions (WMLs), an association suggesting that small-vessel ischemic disease, a major contributor to the development of dementia, including Alzheimer disease, may be preventable through ω-3 treatment.Objective To… Continue reading ω-3 #PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older AdultsA Randomized Clinical Trial
A #hippocampal circuit mechanism to balance #memory reactivation during #sleep
Editor’s summaryDuring sleep, there is an increase in the coordinated firing of neuronal ensembles that were previously active during behavior. These hippocampal sharp-wave ripples are necessary for sleep-dependent memory consolidation. However, how the hippocampus regulates such increases in ensemble reactivation and synchrony while keeping the overall homeostatic balance of the network is not known. Karaba et… Continue reading A #hippocampal circuit mechanism to balance #memory reactivation during #sleep
Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild #Traumatic Brain Injury in the PREVENT #Dementia Study
Importance Traumatic brain injuries (TBI) represent an important, potentially modifiable risk factor for dementia. Despite frequently observed vascular imaging changes in individuals with TBI, the relationships between TBI-associated changes in brain imaging and clinical outcomes have largely been overlooked in community cases of TBI.Objective To assess whether TBI are associated with and interact with midlife changes in… Continue reading Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild #Traumatic Brain Injury in the PREVENT #Dementia Study
The central role of the gut #microbiota in the pathophysiology and management of type 2 #diabetes
The inhabitants of our intestines, collectively called the gut microbiome, comprise fungi, viruses, and bacterial strains. These microorganisms are involved in the fermentation of dietary compounds and the regulation of our adaptive and innate immune systems. Less known is the reciprocal interaction between the gut microbiota and type 2 diabetes mellitus (T2DM), as well as… Continue reading The central role of the gut #microbiota in the pathophysiology and management of type 2 #diabetes
The #dopaminergic system promotes neprilysin-mediated degradation of #amyloid-β in the brain
Deposition of amyloid-β (Aβ) in the brain can impair neuronal function and contribute to cognitive decline in Alzheimer’s disease (AD). Here, we found that dopamine and the dopamine precursor levodopa (also called l-DOPA) induced Aβ degradation in the brain. Chemogenetic approaches in mice revealed that the activation of dopamine release from ventral tegmental area (VTA) neurons… Continue reading The #dopaminergic system promotes neprilysin-mediated degradation of #amyloid-β in the brain
Longitudinal associations between #time perspective and #life satisfaction across adulthood
Time perspective is an important predictor of well-being. How time is represented, is itself subject to developmental change. A time perspective dominated by the future is increasingly replaced by one focused on the present and past as remaining lifetime decreases. These age-related changes supposedly are associated with higher subjective well-being. Previous studies yielded heterogeneous results.… Continue reading Longitudinal associations between #time perspective and #life satisfaction across adulthood
2 Medical News 