Background:Although glucagon-like peptide-1 receptor agonists (GLP-1RAs) have shown potential antidepressant effects, population studies yield inconsistent results. Objective:To compare the risk for depression in older adults with type 2 diabetes (T2D) initiating treatment with GLP-1RAs versus sodium–glucose cotransporter-2 inhibitors (SGLT2is) or dipeptidyl peptidase-4 inhibitors (DPP4is).Design:Target trial emulation study.Setting:U.S. National Medicare administrative data from January 2014 to… Continue reading Glucagon-Like Peptide-1 Receptor Agonists and Risk for #Depression in Older Adults With Type 2 #Diabetes
#Dairy Consumption and the Colonic Mucosa-Associated Gut #Microbiota in Humans—A Preliminary Investigation
Background: Dairy consumption has been associated with various health outcomes that may be mediated by changes in gut microbiota. Methods: This cross-sectional study investigated the association between the colonic mucosa-associated gut microbiota and the self-reported intake of total dairy, milk, cheese, and yogurt. A total of 97 colonic mucosal biopsies collected from 34 polyp-free individuals… Continue reading #Dairy Consumption and the Colonic Mucosa-Associated Gut #Microbiota in Humans—A Preliminary Investigation
Common interventional procedures for chronic non-cancer #spine #pain: a systematic review and network meta-analysis of randomised trials
Objective To address the comparative effectiveness of common interventional procedures for chronic non-cancer (axial or radicular) spine pain.Design Systematic review and network meta-analysis (NMA) of randomised controlled trials (RCTs).Data sources Medline, Embase, CINAHL, CENTRAL, and Web of Science from inception to 24 January 2023.Study selection RCTs that enrolled patients with chronic non-cancer spine pain, randomised… Continue reading Common interventional procedures for chronic non-cancer #spine #pain: a systematic review and network meta-analysis of randomised trials
Integrating the #environmental and genetic architectures of #aging and mortality
Both environmental exposures and genetics are known to play important roles in shaping human aging. Here we aimed to quantify the relative contributions of environment (referred to as the exposome) and genetics to aging and premature mortality. To systematically identify environmental exposures associated with aging in the UK Biobank, we first conducted an exposome-wide analysis… Continue reading Integrating the #environmental and genetic architectures of #aging and mortality
Effect of #broccoli sprout extract and baseline gut microbiota on fasting blood #glucose in #prediabetes: a randomized, placebo-controlled trial
More effective treatments are needed for impaired fasting glucose or glucose intolerance, known as prediabetes. Sulforaphane is an isothiocyanate that reduces hepatic gluconeogenesis in individuals with type 2 diabetes and is well tolerated when provided as a broccoli sprout extract (BSE). Here we report a randomized, double-blind, placebo-controlled trial in which drug-naive individuals with prediabetes… Continue reading Effect of #broccoli sprout extract and baseline gut microbiota on fasting blood #glucose in #prediabetes: a randomized, placebo-controlled trial
The protective role of vitamin #D in BNT162b2 vaccine-related acute #myocarditis
Introduction: Vaccine-related myocarditis is recognized as a rare but important complication, especially after mass-scale mRNA COVID-19 vaccination. Knowledge regarding how to minimize the risk is limited. As NK cells can mediate acute myocarditis after mRNA COVID-19 vaccination and vitamin D may inhibit NK cells via cytokine modulation, we hypothesize that the myocarditis side effect is… Continue reading The protective role of vitamin #D in BNT162b2 vaccine-related acute #myocarditis
Associations Between #Polyphenol Intake, Cardiometabolic Risk Factors and Metabolic Syndrome in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)Author links open overlay panel
BackgroundFruit- and vegetable-rich diets may protect against metabolic syndrome (MetS), partly due to their high polyphenol content.ObjectivesThis study examined the association between dietary polyphenol intake, MetS risk, and cardiometabolic factors in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).MethodsA total of 6387 participants (mean age 49.8 y, 65% female) were included. Food intake was assessed… Continue reading Associations Between #Polyphenol Intake, Cardiometabolic Risk Factors and Metabolic Syndrome in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)Author links open overlay panel
#Sweetener #aspartame aggravates #atherosclerosis through insulin-triggered inflammation
Highlights•Aspartame increases insulin levels through parasympathetic activation•An insulin-dependent mechanism of the aspartame-aggravated atherosclerosis•The CX3CL1-CX3CR1 signaling mediates insulin-induced endothelial inflammation•A CX3CL1-CX3CR1-dependent mechanism of aspartame-exacerbated atherosclerosis SummaryConsumption of artificial sweeteners (ASWs) in various foods and beverages has been linked to an increased risk of cardiovascular diseases (CVDs). However, molecular mechanisms underlying ASW-associated CVD remain unknown. Here, we… Continue reading #Sweetener #aspartame aggravates #atherosclerosis through insulin-triggered inflammation
Long-term survival and durable recovery of #heart failure in patients with triglyceride deposit #cardiomyovasculopathy treated with tricaprin
Heart disease is a major global threat. Triglyceride deposit cardiomyovasculopathy (TGCV) is an emerging, noncommunicable, adult-onset heart disease, first identified in Japanese patients with heart failure (HF) requiring cardiac transplantation1,2,3. In TGCV, defective intracellular lipolysis of long-chain triglycerides (TGs) results in cellular steatosis and energy failure mainly in cardiomyocytes4 and smooth muscle cells5, leading to… Continue reading Long-term survival and durable recovery of #heart failure in patients with triglyceride deposit #cardiomyovasculopathy treated with tricaprin
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