To assess whether initiation of insulin glargine (glargine), compared with initiation of neutral protamine Hagedorn (NPH) or insulin detemir (detemir), was associated with an increased risk of breast cancer in women with diabetes.. Ever use of glargine was not associated with an increased risk of breast cancer compared with NPH (HR 0.97; 95% CI 0.88–1.06)… Continue reading Similar #Breast Cancer Risk in Women Older Than 65 Years Initiating Glargine, Detemir, and NPH Insulins
Red #blood cell dysfunction: a new player in #cardiovascular disease
The primary role of red blood cells (RBCs) is to transport oxygen to the tissues and carbon dioxide to the lungs. However, emerging evidence suggests an important role of the RBC beyond being just a passive carrier of the respiratory gases. The RBCs are of importance for redox balance and are actively involved in the… Continue reading Red #blood cell dysfunction: a new player in #cardiovascular disease
Association of Serum #Folate Levels With Cardiovascular Mortality Among Adults With Rheumatoid #Arthritis
Patients with rheumatoid arthritis (RA) are at high risk for cardiovascular (CV) mortality, attributed to chronic inflammation coupled with elevated circulatory homocysteine levels. Increasing the serum folate level reduces homocysteine, but the association of serum folate concentration with CV mortality in patients with RA has not been previously examined.. A total of 683 patients with… Continue reading Association of Serum #Folate Levels With Cardiovascular Mortality Among Adults With Rheumatoid #Arthritis
Particulate #Matter and Albuminuria, Glomerular Filtration Rate, and Incident #CKD
Exposure to particulate matter (PM) <2.5 μm in aerodynamic diameter (PM2.5) has been linked to detrimental health effects. This study aimed to describe the relationship between long-term PM2.5 exposure and kidney disease, including eGFR, level of albuminuria, and incident CKD.. urinary albumin-creatinine ratio (UACR) ..There was no significant PM2.5-eGFR association at baseline. Each 1-μg/m3 higher… Continue reading Particulate #Matter and Albuminuria, Glomerular Filtration Rate, and Incident #CKD
Pharmacologic Therapies in Patients With Exacerbation of Chronic #Obstructive #Pulmonary Disease: A Systematic Review With Meta-analysis
..Compared with placebo or management without antibiotics, antibiotics given for 3 to 14 days were associated with increased exacerbation resolution at the end of the intervention (odds ratio [OR], 2.03 [95% CI, 1.47 to 2.80]; moderate SOE) and less treatment failure at the end of the intervention (OR, 0.54 [CI, 0.34 to 0.86]; moderate SOE),… Continue reading Pharmacologic Therapies in Patients With Exacerbation of Chronic #Obstructive #Pulmonary Disease: A Systematic Review With Meta-analysis
Serum CA72-4 is specifically elevated in #gout patients and predicts flares
..CA72-4 was highly expressed in patients with gouty arthritis [median (interquartile range) 4.55 (1.56, 32.64) U/ml] compared with hyperuricaemia patients [1.47 (0.87, 3.29) U/ml], healthy subjects [1.59 (0.99, 3.39) U/ml] and other arthritis patients [septic arthritis, 1.38 (0.99, 2.66) U/ml; RA, 1.58 (0.95, 3.37) U/ml; SpA, 1.56 (0.98, 2.85) U/ml; OA, 1.54 (0.94, 3.34) U/ml;… Continue reading Serum CA72-4 is specifically elevated in #gout patients and predicts flares
Let it be: #mindful acceptance down-regulates pain and negative emotion
Mindfulness training ameliorates clinical and self-report measures of depression and chronic pain, but its use as an emotion regulation strategy—in individuals who do not meditate—remains understudied. As such, whether it (i) down-regulates early affective brain processes or (ii) depends on cognitive control systems remains unclear. We exposed meditation-naïve participants to two kinds of stimuli: negative… Continue reading Let it be: #mindful acceptance down-regulates pain and negative emotion
Abnormal Coagulation parameters are associated with poor prognosis in patients with novel #coronavirus #pneumonia
In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern.. Conventional coagulation results and outcomes of consecutive 183 patients with confirmed NCP in Tongji hospital were retrospectively analysed. Results The overall mortality was 11.5%, the non‐survivors revealed significantly higher D‐dimer… Continue reading Abnormal Coagulation parameters are associated with poor prognosis in patients with novel #coronavirus #pneumonia
Effect of dose and duration of reduction in dietary #sodium on blood #pressure levels: systematic review and meta-analysis of randomised trials
... Each 50 mmol reduction in 24 hour sodium excretion was associated with a 1.10 mm Hg (0.66 to 1.54; P<0.001) reduction in SBP and a 0.33 mm Hg (0.04 to 0.63; P=0.03) reduction in DBP. Reductions in blood pressure were observed in diverse population subsets examined, including hypertensive and non-hypertensive individuals. For the same… Continue reading Effect of dose and duration of reduction in dietary #sodium on blood #pressure levels: systematic review and meta-analysis of randomised trials
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