Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction and alcohol-related liver disease (MetALD) exist on a continuous spectrum in which fibrosis stage remains the dominant predictor of liver‑related complications. Contemporary non‑invasive risk stratification uses simple serum scores (e.g., Fibrosis‑4 index [FIB‑4]) as a first step, followed by vibration‑controlled transient elastography (VCTE) or liver‑specific blood… Continue reading Risk Assessment in MASLD and MetALD: Current Approaches and Future Directions
Curcumin Suppresses Growth of Recurrent Colorectal Adenoma After Endoscopic Resection: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial
Introduction: Experimental and limited clinical studies suggest that curcumin has chemopreventive activity in the colorectum. This large-scale clinical trial evaluated the efficacy and safety of curcumin in patients with previously endoscopically resected colorectal neoplasia.Methods: This randomized, double-blind, placebo-controlled multicenter trial enrolled patients with previously resected colorectal neoplasia. Eligible patients were randomly assigned (1:1), using a… Continue reading Curcumin Suppresses Growth of Recurrent Colorectal Adenoma After Endoscopic Resection: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial
Effects of a telehealth-supported home-based exercise program on functional capacity, sarcopenia risk, and patient-reported outcomes in non-dialysis stage 4-5 chronic kidney disease
Background: Evidence on the effects of 12-week telehealth-supported home-based exercise in advanced non-dialysis chronic kidney disease (CKD) remains limited. This study evaluated its effects on functional capacity, sarcopenia risk, and patient-reported outcomes in patients with stage 4-5 CKD.Methods: In this prospective, parallel-group randomized controlled trial (October 2024-July 2025), 54 non-dialysis patients aged ≥45 years with… Continue reading Effects of a telehealth-supported home-based exercise program on functional capacity, sarcopenia risk, and patient-reported outcomes in non-dialysis stage 4-5 chronic kidney disease
Phenotypic clustering and ABC pathway adherence in patients with atrial fibrillation at high risk of bleeding and stroke: Insights from three global registries
Background: Patients with atrial fibrillation (AF) who are at increased risk of both thrombotic and haemorrhagic events represent a heterogeneous and broad clinical entity, characterized by the presence of several Janus-faced risk factors. We aimed to identify clinical phenotypes and assess the association of ABC pathway adherence with one-year outcomes in patients with AF at… Continue reading Phenotypic clustering and ABC pathway adherence in patients with atrial fibrillation at high risk of bleeding and stroke: Insights from three global registries
Limited clinical utility of risk stratification for CT decision-making in patients ≥ 75 years with mild traumatic brain injury
Background: Older adults account for an increasing proportion of emergency department visits for mild traumatic brain injury (mTBI). Although age is incorporated as a high-risk criterion in major clinical decision rules, the operational impact of risk stratification on computed tomography (CT) utilization in very elderly patients remains uncertain.Methods: We conducted a retrospective cohort study including… Continue reading Limited clinical utility of risk stratification for CT decision-making in patients ≥ 75 years with mild traumatic brain injury
Beyond conventional lipid markers: Atherogenic index of plasma and triglyceride-glucose index in relation to cardiometabolic multimorbidity in older adults
Purpose: This study aimed to compare the associations and predictive performance of atherogenic index of plasma (AIP) and the triglyceride-glucose (TyG) index for incident cardiometabolic multimorbidity (CMM).Methods: Data was analyzed from 2261 adults (mean age 63 years; 45.0% men) in the English Longitudinal Study of Ageing without a history of cardiometabolic disease at baseline (2008-2009).… Continue reading Beyond conventional lipid markers: Atherogenic index of plasma and triglyceride-glucose index in relation to cardiometabolic multimorbidity in older adults
Korean Clinical Practice Guidelines for Interstitial Lung Disease: Part 2. Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia characterized by declining lung function, severe dyspnea, and a poor prognosis. Although antifibrotic agents have improved outcomes in patients with IPF, important challenges remain in the diagnosis, monitoring, and long-term management of the disease. Since the publication of the first Korean clinical practice guideline… Continue reading Korean Clinical Practice Guidelines for Interstitial Lung Disease: Part 2. Idiopathic Pulmonary Fibrosis
Explainable Machine Learning for Predicting Deep Vein Thrombosis in Critically Ill Patients with COPD: Development and Multicenter External Validation
Background: Deep vein thrombosis (DVT) is a frequent yet underrecognized complication in critically ill patients with chronic obstructive pulmonary disease (COPD). Existing risk assessment tools are not specifically tailored to this high-risk population. We aimed to develop and externally validate an interpretable machine-learning model for early prediction of DVT in ICU-admitted COPD patients.Methods: Adult COPD… Continue reading Explainable Machine Learning for Predicting Deep Vein Thrombosis in Critically Ill Patients with COPD: Development and Multicenter External Validation
Impact of Pre-injury Statin Use on Mortality and Short-Term Clinical Outcomes Following Intracerebral Hemorrhage: A Propensity-Matched Cohort Study
Background Intracerebral hemorrhage (ICH) is associated with high mortality and limited therapeutic options. The impact of statin therapy on outcomes following ICH remains controversial. Methods A retrospective cohort study was conducted using the TriNetX Global Collaborative Network. Adult patients (≥18 years) with nontraumatic ICH were identified and stratified based on statin use within three months… Continue reading Impact of Pre-injury Statin Use on Mortality and Short-Term Clinical Outcomes Following Intracerebral Hemorrhage: A Propensity-Matched Cohort Study
